Screening method of hypoglycemic drug
A technology for lowering blood sugar and drugs, which is applied in the establishment and application of drug screening methods. It can solve the problems of inability to evaluate the activity of active substances and mechanism of action, large differences between species in animal model experiments, and complex mechanism of action. The effect of high-throughput screening, high accuracy, and small sample volume
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Embodiment 1
[0034] Embodiment 1 builds a model
[0035] 1. Construction and verification of hyperglycemia cell model
[0036] Depend on figure 1 It can be seen that, compared with the control group (cells cultured with 5.6mM glucose), after 16.7mM and 33.3mM glucose acted on the cells for 24h, the cell survival rate decreased to varying degrees, and the cell survival rate of the 33.3mM glucose group decreased to (81.23 ± 1.21 )%. The 33.3mM glucose+5μmol / L metformin hydrochloride group was significantly higher than the 33.3mM glucose group (85.53±2.14)%, the difference was statistically significant (P<0.05). It shows that after 16.7mM and 33.3mM glucose acted on the cells for 24 hours, it has a damaging effect on INS-1 cells, while 33.3mM glucose + 5μmol / L metformin hydrochloride can alleviate the damage caused by high glucose on cells; it is finally determined that the 33.3mM treatment group is the model Group.
[0037] Pancreatic cells are specialized to sense elevated glucose level...
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