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Fingerprint spectrum detection method for Ganshuang granules

A fingerprint and detection method technology, applied in the field of spectrum detection, can solve the problems that it is difficult to fully reflect the comprehensive information of drugs and complex components, and achieve the effects of high reliability, good reproducibility and high stability

Pending Publication Date: 2021-10-22
BAODING BUCHANG TIANHAO PHARMA +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, because Ganshuang Granules have many medicinal flavors and complex components, the analysis of individual components is somewhat one-sided. To control the quality of Ganshuang Granules, it is not enough to characterize and control only one or two chemical components, and it is difficult to fully reflect the comprehensive information of the drug.

Method used

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  • Fingerprint spectrum detection method for Ganshuang granules
  • Fingerprint spectrum detection method for Ganshuang granules
  • Fingerprint spectrum detection method for Ganshuang granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0062] The Ganshuang granule fingerprint detection method provided in this example comprises the following steps:

[0063] 1) Carry out ultrasonic extraction of Ganshuang granules with methanol to obtain a solution of the test substance to be detected;

[0064] The specific process is: accurately weigh 0.3g of Ganshuang granule powder, put it in a stoppered conical flask, add 50mL of 70% methanol aqueous solution, ultrasonically treat for 30min, let it cool, and use 70% methanol aqueous solution to make up Lost mass, constant volume, shake well, centrifuge at 1200rpm for 10min, take the supernatant, pass through 0.3μm microporous membrane, and the filtrate is the test solution.

[0065] In this embodiment, the ultrasonic power is 600W, the ultrasonic frequency is 35KHZ, and the time is 20min.

[0066] In this example, Ganshuang granule is the test product of 200816 batches.

[0067] 2) adopt ultra high performance liquid chromatography to carry out high performance liquid ch...

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Abstract

The invention belongs to the technical field of spectrum detection, and relates to a fingerprint spectrum detection method for Ganshuang granules, which comprises: 1) carrying out ultrasonic extraction on Ganshuang granules by using methanol to obtain a to-be-detected test solution; (2) carrying out high performance liquid chromatography detection on the test solution by adopting ultra-high performance liquid chromatography, and recording chromatographic data within 40 minutes; and generating the fingerprint spectrum of the Ganshuang granules from the chromatographic data according to the 'Traditional Chinese Medicine Chromatographic Fingerprint Similarity Evaluation System A'. The detection method provided by the invention has the characteristics of high accuracy, high stability and good repeatability, can comprehensively reflect the quality of the Ganshuang granules, and ensures the product quality.

Description

technical field [0001] The invention belongs to the technical field of spectrum detection and relates to a fingerprint spectrum detection method of Ganshuang granules. Background technique [0002] The fingerprint of traditional Chinese medicine refers to the chromatogram or spectrum of a certain type or several types of components that are common in certain Chinese medicinal materials or Chinese patent medicines. The characteristics of fingerprints of traditional Chinese medicine include integrity, characteristic and quantification, highlighting the complete appearance of traditional Chinese medicine, and its role in the study of active ingredients of traditional Chinese medicine, quality control and identification of traditional Chinese medicine is becoming more and more prominent. [0003] Ganshuang Granules (Guoyao Zhunzi Z20027671) is an exclusive traditional Chinese medicine variety produced by Baoding Buchang Tianhao Pharmaceutical Co., Ltd. It has a unique curative e...

Claims

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Application Information

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IPC IPC(8): G01N30/86G01N30/02G01N30/34G01N30/74G01N30/06G01N30/14
CPCG01N30/8686G01N30/02G01N30/34G01N30/74G01N30/06G01N30/14G01N30/8634G01N30/8679G01N2030/146Y02A50/30
Inventor 刘峰韩东彭修娟李林林许刚陈衍斌刘金华程茜菲李波谢伟
Owner BAODING BUCHANG TIANHAO PHARMA
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