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Ferroptosis inhibitor drug for activating cell GXP4 enzyme and application of ferroptosis inhibitor drug

A technology of ferroptosis and inhibitors, which is applied in the field of medicine, can solve the problems of lack of specific drugs to prevent complications, cardiac function damage of patients, myocardial cell ferroptosis, etc., and achieve the goal of promoting local economic development, reducing medical costs, and eliminating peroxidation Effect

Active Publication Date: 2021-10-12
恩施极硒生物科技有限公司
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Problems solved by technology

[0003] (2) Clinically, bacterial infection causes ferroptosis of myocardial cells, causing irreversible damage to the patient's cardiac function, and there is a lack of specific drugs to prevent complications
However, dextropropyl imine can aggravate the bone marrow suppression caused by chemotherapy drugs, and combined use with chemotherapy affects the anti-tumor effect, and long-term use can cause secondary malignant tumors

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  • Ferroptosis inhibitor drug for activating cell GXP4 enzyme and application of ferroptosis inhibitor drug
  • Ferroptosis inhibitor drug for activating cell GXP4 enzyme and application of ferroptosis inhibitor drug
  • Ferroptosis inhibitor drug for activating cell GXP4 enzyme and application of ferroptosis inhibitor drug

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[0038]The embodiments described below are not just descriptions for a specific embodiment, but selective descriptions for potential embodiments with certain technical features, and some technical features are not necessarily present. Specific to a specific embodiment, it is a combination of some of the following technical features, as long as the combination is not logically contradictory or meaningless. "May / may be" (may, may be, indicating choice, implying that there may be other alternatives appearing anywhere in the present invention; except for the expression "ability" in the context) is a preferred embodiment , which may be potentially other alternatives. When the technical terms "approximately", "approximately" and "approximately" and other approximate description words (if any) appearing in any position of the present invention are described, the meaning to be expressed is not to require that the data obtained after strict actual parameter measurement be strictly It c...

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Abstract

The invention provides a ferroptosis inhibitor drug for activating a cell GXP4 enzyme and an application of the ferroptosis inhibitor drug. Selenium cordyceps militaris serving as a drug preparation can improve the activity of the GPX4 enzyme by three times and inhibit ferroptosis induced by ferroptosis inducers Erastatin and RSL3. Under the dosage of 0.75 mg / kg (converted according to 400 micrograms per day of a human body), the drug has the effect of inhibiting adriamycin-induced cardiac cell ferroptosis, and the effective rate is 90% and is far higher than that of a clinical drug dexrazoxane (50%). Selenium cordyceps militaris inhibits ferroptosis by improving the activity of glutathione peroxidase (GPX4), and the method is a new method for treating ferroptosis related diseases.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a ferroptosis inhibitor drug for activating cell GXP4 enzyme and its application. Specifically, the invention provides a method for preparing and regulating cell glutathione peroxidase (GPX4) by selenium Cordyceps militaris. ) applications in active pharmaceuticals. The invention also provides the application of selenium cordyceps in inhibiting ferroptosis. Background technique [0002] (1) Ferroptosis is a programmed death catalyzed by iron and mediated by peroxidation of polyunsaturated fatty acids. The accumulation of intracellular ferrous ions, lipid peroxidation and inactivation of the protective mechanism of cell membrane peroxidative damage are the three key factors triggering ferroptosis. Iron pools in cells mainly exist as ferrous ions, which can catalyze lipid peroxidation through the Fenton reaction. Lipid peroxidation is divided into spontaneous peroxidation and...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A61K33/04A61K9/52A61K47/04A61P35/00A61P9/00A23L33/10A23L31/00A61K31/704
CPCA61K36/068A61K33/04A61K31/704A61K9/5115A61P35/00A61P9/00A23L33/10A23L31/00A61K2236/331A61K2236/53A23V2002/00A61K2300/00A23V2200/30A23V2250/208
Inventor 黄楚鹰王莉
Owner 恩施极硒生物科技有限公司
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