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Application of beta-As4S4 in preparation of medicine for treating hematological malignant tumors

A technology of -as4s4, purpose, applied in the field of drugs for the treatment of hematological malignancies, and can solve the problem of no hematological malignancies

Pending Publication Date: 2021-10-12
SICHUAN SINCO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] However, in the prior art, no β-As 4 S 4 Reports on the Treatment of Hematological Malignancies

Method used

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  • Application of beta-As4S4 in preparation of medicine for treating hematological malignant tumors
  • Application of beta-As4S4 in preparation of medicine for treating hematological malignant tumors
  • Application of beta-As4S4 in preparation of medicine for treating hematological malignant tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: β-As 4 S 4 Identification of crystal samples

[0044] 1. Testing instrument: Bruker powder X-ray diffractometer, model: D8 Advance.

[0045] 2. The main working parameters of the instrument:

[0046] Cu target, Ka radiation, 40kV, 40mA, RS slit: 3mm, scanning range: 5°-80°, scanning mode: continuous scanning, data interval: 0.02°, counting time: 0.1 second / step.

[0047] 3. Test results: see figure 2 .

[0048] The above is the measured X-ray diffraction spectrum of the sample, and the bottom is the β-As in the JCPDS spectral library (PDF2) 4 S 4 The standard spectrum of the sample (card number: 01-088-1657), the main diffraction peak on the measured X-ray diffraction spectrum of the sample and the β-As in PDF2 4 S 4 The standard spectrum (card number: 01-088-1657) is in good agreement, proving that the main crystal phase component in the sample is As 4 S 4 (Arsenic sulfide) (Note: There are impurity peaks at 17.002° and 20.600°).

Embodiment 2

[0049] Example 2: wettability

[0050] Wettability refers to the propensity of a solid to come into contact with one fluid rather than another. Generally, it can be defined as the phenomenon that the solid interface changes from a solid-gas interface to a solid-liquid interface. Wettability is determined by the structure of the outermost layer of a solid and is one of its intrinsic properties.

[0051] 1. Testing instrument: high-speed video optical contact angle measuring instrument: OCAH 200, German Dataphysics company.

[0052] 2. Test method: Press realgar fine powder (200 mesh) into a disc with a smooth surface and a diameter of 1 cm, place it on the stage, squeeze out the liquid slowly with a needle and drop it on the disc, and take pictures of the liquid drop and the disc with a high-speed camera. During the contact process of the wafer, record and measure the contact angle between the liquid and the wafer. The shooting speed is 200 frames / min.

[0053] 3. Test resu...

Embodiment 3

[0056] Example 3: Dissolution

[0057] 1. ICP-AES: American VARIN company, model: VISTA-MPX,

[0058] 2. Analysis conditions: RF, power: 1.15kw, cooling gas flow: 15L / min, atomizer gas flow: 0.75L / min, observation height: 12mm, auxiliary gas flow: 1.5L / min.

[0059] 3. Results:

[0060] Natural realgar: see Table 1 and Figure 5 .

[0061] Table 1: Time-concentration data of natural realgar dissolved in artificial gastric juice, artificial intestinal juice, and pure water

[0062]

[0063] β-As 4 S 4 Samples: See Table 2 and Image 6 .

[0064] Table 2: β-As 4 S 4 Dissolution time-concentration data in artificial gastric juice, artificial intestinal juice, pure water

[0065]

[0066]

[0067] It can be seen that β-As 4 S 4 The dissolution rate in pure water and artificial gastrointestinal fluid is higher than that of natural realgar, and the dissolution amount is greater than that of artificial realgar. Taking the dissolution in artificial gastric juice ...

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Abstract

The invention relates to an application of beta-As4S4 in preparation of a medicine for treating hematological malignant tumors. The hematological malignant tumors are selected from leukemia, lymphoma, multiple myeloma, myelodysplastic syndrome, refractory anemia with increased immature cells, and refractory anemia during conversion into leukemia. The beta-As4S4 is stable and controllable in quality and can be wetted by water, and the wettability is superior to that of natural realgar. Meanwhile, compared with natural realgar, beta-As4S4 has better dissolubility in pure water and human gastrointestinal fluid, and has a better apoptosis induction effect on hematological malignant tumor cells.

Description

[0001] This application is an application dated February 24, 2017 entitled "β-As 4 S 4 Use in the preparation of drugs for the treatment of hematological malignancies" is a divisional application of Chinese Patent Application No. 201710101939.0. technical field [0002] The invention belongs to the field of medicine and relates to β-As 4 S 4 Use in the preparation of medicines for treating hematological malignancies. Background technique [0003] Realgar is a traditional mineral medicine, which was first recorded in "Shen Nong's Materia Medica" and listed as a middle grade. Traditional Chinese medicine is often used to treat carbuncle, swollen furuncle, and abdominal pain caused by insect accumulation. In recent years, realgar and its compound preparations have achieved good results in the treatment of acute myeloid leukemia. [0004] Research has found that there are four crystal forms of realgar: α-As 4 S 4 , β-As 4 S 4 , χ-As 4 S 4 and pseudorealgar (pararealgar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/36A61K45/06A61P35/00A61P35/02
CPCA61K33/36A61K45/06A61P35/00A61P35/02A61K2300/00
Inventor 张志杰黄祥彬
Owner SICHUAN SINCO PHARMA
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