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A kind of pharmaceutical composition and its application for treating myelodysplastic syndrome

A technology for myelodysplasia and syndrome, which is applied in the direction of drug combination, active ingredients of hydroxyl compounds, and medical raw materials derived from gymnosperm subphylum, etc. Obvious problems, to achieve the effect of no drug resistance, no toxic side effects, and no relapse

Active Publication Date: 2021-01-05
刘尚勤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment ideas of these drugs are implemented in the specific treatment plan or medication strategy of the disease, but there are still shortcomings such as long treatment course, slow effect, ineffective effect, and not easy to be accepted by patients.
Throughout the various reports of TCM treatment of myelodysplastic syndrome (refractory anemia), most of the therapeutic effects are difficult to reach the complete remission and partial remission in the curative effect evaluation criteria of the International Working Group (MDS-IWG) for myelodysplastic syndrome. ease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1: Formula and preparation for the treatment of myelodysplastic syndrome (refractory anemia)

[0059] Prescription: 15 parts of Poria, 15 parts of Astragalus, 15 parts of Fritillaria, 12 parts of Atractylodes, 12 parts of Danpi, 12 parts of Codonopsis, 12 parts of Taxus chinensis, 10 parts of bitter almond, 12 parts of Nansha ginseng, 12 parts of Shengdi, 6 parts of Licorice share.

[0060] The preparation steps are as follows:

[0061] Weigh each piece of Chinese herbal medicine according to the formula proportion, according to the traditional process, add about 600 ml of water to the medicine jar, soak it for about 30 minutes, boil it on a low fire for about 30 minutes, form a decoction, and then add water to the medicine jar About 550 ml, soak for about 20 minutes, boil on low heat for about 25 minutes, make a decoction, mix the two decoctions, and take it warm.

Embodiment 2

[0062] Example 2: Prescription and preparation for the treatment of myelodysplastic syndrome (refractory anemia)

[0063] Prescription: Poria 20g, Astragalus 20g, Fritillaria 20g, Atractylodes 15g, Danpi 15g, Codonopsis 15g, Taxus 15g, Bitter almond 15g, Nansha ginseng 15g, Shengdi 15g, Licorice 6g gram.

[0064] Preparation steps: Weigh each piece of Chinese herbal medicine according to the formula proportion, according to the traditional process, add about 650 ml of water to the medicine pot, soak for about 30 minutes, boil for about 30 minutes after low heat, form a decoction, and then add it to the medicine. Add about 600 ml of water to the jar, soak for about 20 minutes, boil on low heat and continue for about 25 minutes to form a decoction, mix the two decoctions, and take it warm.

Embodiment 3

[0065] Example 3: Prescription and preparation for the treatment of myelodysplastic syndrome (refractory anemia)

[0066] Prescription: Poria 30g, Astragalus 30g, Fritillaria 30g, Atractylodes 25g, Danpi 25g, Codonopsis 25g, Taxus 25g, Bitter almond 25g, Nansha ginseng 25g, Shengdi 25g, Licorice 9 gram.

[0067] Preparation steps: Weigh each piece of Chinese herbal medicine according to the formula proportion, according to the traditional process, add about 800 ml of water to the medicine jar, soak for 30 minutes, boil for about 30 minutes on low heat, form a decoction, and then put it in the medicine jar. Add about 700 ml of water, soak for 20 minutes, boil over low heat and continue for 25 minutes to form a decoction, mix the two decoctions, and serve warm.

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PUM

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Abstract

The invention provides a medicine for treating myelodysplastic syndrome. The medicine is prepared from the following components of 10 to 40 parts of poria cocos, 10 to 40 parts of radix astragali seuhedysari, 10 to 40 parts of bulbus fritillariae thunbergii, 10 to 35 parts of bighead atractylodes rhizome, 10 to 35 parts of cortex moutan, 10 to 35 parts of radix codcnopsitis pilosulas, 10 to 35 parts of fructus taxi wallichianae, 10 to 35 parts of semen armeniacae amarae, 10 to 35 parts of radix adenophorae, 10 to 35 parts of radix rehmanniae, and 3 to 15 parts of liquorice root. The medicinehas the advantages that by scientifically compounding the traditional Chinese herbs, the traditional Chinese medicine is prepared by repeated verification of clinical experiment; the medicine can reach good treatment effect on the myelodysplastic syndrome (refractory anemia); when the medicine is used together with Western medicines of thalidomide and the like, a patient who relies on blood transfusion for a long time can get rid of blood transfusion, or the blood source is greatly reduced, the recurrence is prevented, the progress of disease is blocked, the living quality is improved, and thepatient can healthily survive for a long time; the toxic and side effects are low, the treatment cost is low, and the medicine can be easily accepted by the patient.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine prescription or pharmaceutical composition for the treatment of myelodysplastic syndrome (refractory anemia) and application thereof. Background technique [0002] Myelodysplastic syndromes (refractory anemia) (myelodysplastic syndromes, MDS) are a group of malignant clonal diseases of hematopoietic stem / progenitor cells [Barzi A, Sekeres MA. Myelodysplastic syndromes: a practical approach to diagnosis and treatment. Cleve Clin J Med , 2010, 77: 37-44.], is a common malignant hematological disease in the elderly, with a high incidence, the incidence rate of people over 70 years old is 20~35 / 100,000, and it has become a malignant disease that seriously threatens human health. The number of new cases in my country is about 70,000 every year. With the aging of the population in my country, the incidence rate is gradually increasing. The pat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8966A61K38/18A61P35/02A61P7/06A61K31/454A61K31/203
CPCA61K31/203A61K31/454A61K36/076A61K36/13A61K36/284A61K36/342A61K36/344A61K36/481A61K36/484A61K36/65A61K36/71A61K36/736A61K36/804A61K36/8966A61K38/1816A61P7/06A61P35/02A61K2300/00
Inventor 马梓刘尚勤
Owner 刘尚勤
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