Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Drug-loaded artificial bone with multi-layer core-shell structure and preparation method thereof

A multi-layer core-shell structure, artificial bone technology, applied in the medical field, can solve the problems of drug contamination, low strength of drug-loaded artificial bone, achieve no difference in performance, realize the diversity and personalization of drugs, and reduce the risk of infection. Effect

Active Publication Date: 2022-07-12
PARTICLE CLOUD BIOTECHNOLOGY (HANGZHOU) CO LTD
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the above-mentioned shortcoming of the prior art, provide a kind of drug-loaded artificial bone of multi-layer core-shell structure and its preparation method, to solve the low strength of the drug-loaded artificial bone prepared in the prior art, and the drug is easily damaged. pollution problem

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drug-loaded artificial bone with multi-layer core-shell structure and preparation method thereof
  • Drug-loaded artificial bone with multi-layer core-shell structure and preparation method thereof
  • Drug-loaded artificial bone with multi-layer core-shell structure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0049] (1) Preparation of binder: 10 g of polyvinyl alcohol and 90 g of sterile water for injection were prepared into an aqueous solution of polyvinyl alcohol with a mass fraction of 10%, placed in a wide-mouth bottle with a lid and heated in a water bath at 60 °C for 2 hours to swell , and then stirred at 250r / min for 2h in a 96°C magnetic stirrer to completely dissolve to form a homogeneous solution;

[0050] (2) Preparation of drug-loaded artificial bone shell paste: Mix hydroxyapatite and β-tricalcium phosphate in a mass ratio of 6:4, and then mix with a binder solution in a mass ratio of 1:1, set Stir it in a mixer at a speed of 2000r / min for 4 times, 1min each time, then put it into the barrel, and defoaming it in a homogenizer at a speed of 3000r / min for 2 times, 2.5mim each time, to obtain a uniform shell printing paste body.

[0051] (3) Preparation of drug-loaded artificial bone core slurry: the anti-tuberculosis drug amikacin and the binder solution were mixed at ...

Embodiment example 2

[0059] (1) Preparation of binder: 6g of collagen and 94g of sterile water for injection were prepared into a collagen binder solution with a mass fraction of 6%, placed in a wide-mouth bottle with a lid, and in a magnetic stirrer with Stir at 300r / min for 1.5h to completely dissolve to form a homogeneous solution;

[0060] (2) Preparation of drug-loaded artificial bone shell paste: Mix the hydroxyapatite and the binder solution at a mass ratio of 1:1.25, place them in a mixer and stir at a speed of 2000 r / min for 5 times, 1 min each time, Then put it into the barrel, and defoaming in the homogenizer at a speed of 3000r / min for 4 times, 2mim each time, to obtain a uniform shell printing paste.

[0061] (3) Preparation of drug-loaded artificial bone core slurry: the antibiotic levofloxacin and penicillin V were mixed in a mass ratio of 1:1, and then mixed with the binder solution in a mass ratio of 1:1.5, and placed in a mixer at 2000 r Stir at a speed of / min for 5 times, each...

Embodiment example 3

[0068] (1) Preparation of binder: 8 g of chitosan and 92 g of sterile water for injection were prepared into an aqueous solution of chitosan with a mass fraction of 8%, placed in a wide-mouth bottle with a lid, and stirred at 450 r in a magnetic stirrer. Stir for 1h at / min speed to completely dissolve to form a homogeneous solution;

[0069] (2) Preparation of drug-loaded artificial bone shell paste: mix the β-tricalcium phosphate and the binder solution at a mass ratio of 1:1.5, place them in a mixer and stir at a speed of 1500 r / min for 3 times, 2 min each time , and then put it into the barrel, and degassed in a homogenizer at a speed of 1500r / min for 5 times, each 5mim, to obtain a uniform shell printing paste.

[0070] (3) Preparation of drug-loaded artificial bone inner core slurry: the chemotherapeutic drug 5-fluorouracil and the binder solution were mixed at a mass ratio of 1:2, and then the chemotherapeutic drug mitoxantrone and the binder solution were mixed at a ra...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a drug-carrying artificial bone with a multi-layer core-shell structure and a preparation method thereof. The artificial bone is composed of multiple layers of core-shell units staggered and stacked, and the printing directions of the upper and lower layers of the core-shell units are at a certain angle, so that the Pores can be formed between the core-shell units of two adjacent layers to facilitate the gradual release of the drug; a drug is arranged in the middle of each core-shell unit, so that the drug of each core-shell unit is individually wrapped, combined with the pore structure, so that each The drugs in the core-shell unit can be controlled release from the pores.

Description

technical field [0001] The invention belongs to the field of medical technology, and in particular relates to a drug-carrying artificial bone with a multi-layer core-shell structure and a preparation method thereof. Background technique [0002] Soft tissue injury and wound contamination in open fractures are prone to soft tissue infection or osteomyelitis, which often leads to delayed fracture union or even nonunion. Therefore, soft tissue infection and posttraumatic osteomyelitis of open fractures have always been important clinical problems. The conventional treatment methods are: strict debridement, proper fixation, closing the wound as early as possible, and applying sufficient, broad-spectrum and powerful antibiotics to prevent and treat infection. However, long-term systemic application of antibiotics may bring about a series of side effects, such as liver and kidney function damage, etc., and there are disadvantages such as difficulty in entering the blood supply-def...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/16A61L27/20A61L27/24A61L27/02A61L27/10A61L27/12A61L27/54B33Y10/00B33Y70/10B33Y80/00
CPCA61L27/12A61L27/025A61L27/10A61L27/20A61L27/16A61L27/24A61L27/54B33Y80/00B33Y70/10B33Y10/00A61L2300/406A61L2300/404A61L2300/416A61L2300/412A61L2430/02
Inventor 曾庆丰杨智宇张新平
Owner PARTICLE CLOUD BIOTECHNOLOGY (HANGZHOU) CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com