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Drug-loaded artificial bone with multi-layer core-shell structure and preparation method of drug-loaded artificial bone

A multi-layer core-shell structure, artificial bone technology, applied in the medical field, can solve the problems of drug contamination, low strength of drug-loaded artificial bone, achieve no difference in performance, realize the diversity and individualization of drugs, and reduce the risk of infection. Effect

Active Publication Date: 2021-10-08
PARTICLE CLOUD BIOTECHNOLOGY (HANGZHOU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the above-mentioned shortcoming of the prior art, provide a kind of drug-loaded artificial bone of multi-layer core-shell structure and its preparation method, to solve the low strength of the drug-loaded artificial bone prepared in the prior art, and the drug is easily damaged. pollution problem

Method used

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  • Drug-loaded artificial bone with multi-layer core-shell structure and preparation method of drug-loaded artificial bone
  • Drug-loaded artificial bone with multi-layer core-shell structure and preparation method of drug-loaded artificial bone
  • Drug-loaded artificial bone with multi-layer core-shell structure and preparation method of drug-loaded artificial bone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0049] (1) Preparation of binder: 10 g of polyvinyl alcohol and 90 g of sterilized water for injection are prepared into a 10% polyvinyl alcohol aqueous solution, placed in a jar with a lid, heated and swelled in a water bath at 60°C for 2 hours , and then stirred in a 96°C magnetic stirrer at a speed of 250r / min for 2h to completely dissolve and form a homogeneous solution;

[0050] (2) Preparation of drug-loaded artificial bone shell paste: mix hydroxyapatite and β-tricalcium phosphate at a mass ratio of 6:4, and then mix with binder solution at a mass ratio of 1:1, and set Stir in the mixer at a speed of 2000r / min for 4 times, each time for 1min, then put it into the barrel, and degas it in a homogenizer at a speed of 3000r / min for 2 times, each time at 2.5mim, to obtain a uniform shell printing paste body.

[0051] (3) Preparation of the drug-loaded artificial bone core slurry: mix the anti-tuberculosis drug amikacin and the binder solution at a mass ratio of 1:2, place i...

Embodiment example 2

[0059] (1) Preparation of binder: 6g of collagen and 94g of sterilized water for injection are mixed with a mass fraction of 6% collagen binder solution, placed in a jar with a lid, and placed in a magnetic stirrer with Stir at 300r / min for 1.5h to completely dissolve and form a uniform solution;

[0060] (2) Preparation of drug-loaded artificial bone shell paste: mix hydroxyapatite and binder solution at a mass ratio of 1:1.25, place in a mixer and stir at a speed of 2000r / min for 5 times, each time for 1min, Then put it into the barrel, and degas it in a homogenizer at a speed of 3000r / min for 4 times, each time 2mim, to obtain a uniform shell printing paste.

[0061] (3) Preparation of drug-loaded artificial bone core slurry: the antibiotic levofloxacin and penicillin V were mixed in a mass ratio of 1:1, and then mixed with the binder solution in a mass ratio of 1:1.5, and placed in a mixer at 2000rr. Stir at a speed of 1 / min for 5 times, each time for 20s, and then put it...

Embodiment example 3

[0068] (1) preparation binder: the chitosan of 8g and 92g sterilized water for injection are mixed with the chitosan aqueous solution that mass fraction is 8%, is placed in the jar with cover, in magnetic stirrer with 450r Stir at a speed of 1 / min for 1 hour to completely dissolve and form a homogeneous solution;

[0069] (2) Preparation of drug-loaded artificial bone shell paste: mix β-tricalcium phosphate and binder solution at a mass ratio of 1:1.5, place in a mixer and stir at a speed of 1500r / min for 3 times, each time for 2 minutes , and then put it into the barrel, degassing 5 times in a homogenizer at a speed of 1500r / min, 5mim each time, to obtain a uniform shell printing paste.

[0070] (3) Prepare drug-loaded artificial bone core slurry: mix the chemotherapeutic drug 5-fluorouracil and the binder solution at a mass ratio of 1:2, and then mix the chemotherapeutic drug mitoxantrone and the binder solution at a ratio of 1:1.25 The mass ratio was mixed, placed in a mix...

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Abstract

The invention discloses a drug-loaded artificial bone with a multilayer core-shell structure and a preparation method thereof. The artificial bone is formed by stacking multiple layers of core-shell units in a staggered mode, and the printing directions of the upper layer of the core-shell unit and the lower layer of the core-shell unit form a certain angle, so that pores can be formed between every two adjacent layers of core-shell units so as to be convenient to gradually release drugs. The drug is arranged in the middle of each core-shell unit, so that the drug in each core-shell unit is independently wrapped, and the drug in each core-shell unit can be controllably released from pores in combination with a pore structure.

Description

technical field [0001] The invention belongs to the field of medical technology, and in particular relates to a drug-loaded artificial bone with a multilayer core-shell structure and a preparation method thereof. Background technique [0002] Soft tissue injury and wound contamination in open fractures are prone to soft tissue infection or osteomyelitis, often leading to delayed union or even nonunion of fractures. Therefore, soft tissue infection and posttraumatic osteomyelitis in open fractures have always been important clinical problems. The routine treatment methods are: strict debridement, proper fixation, early closure of the wound as much as possible, and full-body application of sufficient, broad-spectrum, and potent antibiotics to prevent infection. However, long-term systemic application of antibiotics may bring about a series of side effects such as: liver and kidney damage, etc., and there are disadvantages that the drug is difficult to enter the lesion area lac...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/20A61L27/24A61L27/02A61L27/10A61L27/12A61L27/54B33Y10/00B33Y70/10B33Y80/00
CPCA61L27/12A61L27/025A61L27/10A61L27/20A61L27/16A61L27/24A61L27/54B33Y80/00B33Y70/10B33Y10/00A61L2300/406A61L2300/404A61L2300/416A61L2300/412A61L2430/02
Inventor 曾庆丰杨智宇张新平
Owner PARTICLE CLOUD BIOTECHNOLOGY (HANGZHOU) CO LTD
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