High-activity slow-release pain-relieving patch and preparation process thereof

Abstract

The invention relates to a high-activity slow-release pain-relieving patch and a preparation process thereof. The high-activity slow-release pain-relieving patch comprises a backing layer, a main body layer and an isolation layer which are sequentially stacked, wherein the main body layer comprises the following components: a matrix, active ingredients and an active ingredient slow-release inclusion material, wherein the matrix comprises 30-50wt% of a framework material and 12-28wt% of an auxiliary agent; the active ingredients comprise 6-12wt% of methyl salicylate, 5-8wt% of menthol and 1-4wt% of camphor; and the active ingredient slow-release inclusion material accounts for 6-18wt%. According to the high-activity slow-release pain-relieving patch, medicines with high activity and high volatility, namely methyl salicylate, menthol and camphor, are selected as the main body of the high-activity slow-release pain-relieving patch, and the active ingredients in the main body are included by adopting the slow-release inclusion material, so that the content of each active ingredient is kept to the maximum extent and is continuously and stably released, and the effectiveness of the medicines is ensured; and the matrix material with low sensitization and hydrophilicity is selected, and the preparation process adopts an innovative solvent-free production process technology, so that the transdermal patch is not easily allergic to a human body when being used for the human body, and the safety of the medicines is ensured.

Description

technical field [0001] The invention belongs to the technical field of drug transdermal patch preparation technology, and in particular relates to a highly active sustained-release pain-relieving patch and a preparation process thereof. Background technique [0002] Transdermal patches are effective in treating diseases, especially rheumatic joint pain, muscle pain, sprains, cervical spine, waist and leg pain, etc., and occupy a large proportion in clinical use. Transdermal administration is the third largest route of administration besides oral administration and injection. However, traditional analgesic transdermal preparations, such as black plasters and rubber plasters, are highly irritating and sensitizing, and the drug loading is small, which greatly limits the further development of transdermal preparations. [0003] At present, the traditional production method of the domestic transdermal plaster is the solvent method, for example, the patent document with the publi...

AI Technical Summary

Problems solved by technology

However, traditional analgesic transdermal preparations, such as black plasters and rubber plasters, have strong irritation and sensitization, and the drug loading is small, which greatly limits the further development of transdermal preparations.

[0003] At present, the traditional production method of the domestic transdermal plaster is the solvent method, for example, the patent document with the publication number CN107375891A discloses a preparation method of an external plaster for expelling rheumatism; because the solvent method uses gasoline as a solvent in large quantities, there is 3 major disadvantages: 1. Gasoline is flammable and explosive, with strict requirements for anti-explosion and fire prevention measures, and the cost of safety and environmental protection is extremely high; 2. Because the traditional solvent method production process requires high-temperature drying to remove solvents, the active ingredients of highly active and volatile drugs are dried with solvents. 3. Gasoline has an anesthetic effect on the central nervous system, is harmful to the skin, and easily causes skin allergies.