Preparation method of trifluoroisopropanol
A technology for trifluoroisopropanol and trifluoroacetaldehyde is applied in the preparation of 1,1,1-trifluoro-2-propanol and in the field of preparation of trifluoroisopropanol, which can solve the problems of unsuitable industrial production and raw materials. Inflammable and explosive, large equipment investment and other problems, to achieve the effect of high yield, short reaction process and simple preparation process
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Embodiment 1
[0024] In the dry reaction kettle, 11.4g (0.075mol) of cesium fluoride was added under the protection of nitrogen, the temperature was lowered to -10°C, and 900ml (1.8mol) of 2.0mol / L tetrahydrofuran solution of methylmagnesium chloride was added under stirring, and then three A mixture of 147.03g (1.50mol) of fluoroacetaldehyde and 375mL of tetrahydrofuran. After dropping, slowly warm up to 0°C and react for 10h. Add 3ml of water to quench the reaction and purify to obtain 160.33g of colorless liquid namely 1,1,1-trifluoro-2-propanol, GC purity 99.2% (area normalization method), yield 95.01%
Embodiment 2
[0026] The ratio of methylmagnesium chloride to trifluoroacetaldehyde was changed to 1:1, and the others were the same as in Example 1 to synthesize 1,1,1-trifluoro-2-propanol with a yield of 95.20%.
Embodiment 3
[0028] The ratio of methylmagnesium chloride to trifluoroacetaldehyde was changed to 1:1.2, and the others were the same as in Example 1 to synthesize 1,1,1-trifluoro-2-propanol with a yield of 96.34%.
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