Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Mitochondria-targeted glutathione derivative nanopreparation and application thereof

A technology of glutathione and nano preparations, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of reduced efficiency and low bioavailability of drugs, and achieve the effect of protecting cells from apoptosis and strong mitochondrial protection

Active Publication Date: 2021-10-01
WENZHOU MEDICAL UNIV +1
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the process of drug delivery, the static (tissue barriers such as cornea) and dynamic barriers (physiological effects such as blinking) of the ocular surface make the bioavailability of drugs low, which is a common key problem
At the same time, as a mitochondria-targeted drug, it faces cell membrane barriers, mitochondrial membrane barriers, and intracellular metabolic barriers in the process of mitochondrial targeted delivery, which reduces the efficiency

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Mitochondria-targeted glutathione derivative nanopreparation and application thereof
  • Mitochondria-targeted glutathione derivative nanopreparation and application thereof
  • Mitochondria-targeted glutathione derivative nanopreparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. The oxidized GSH (abbreviated as GSSG) and the triphenylphosphine compound (abbreviated as TPP) with a carboxyl terminal are reacted (excessive TPP) under a catalyst (such as EDC / NHS) to form TPP-modified GSSG (TPP- GSSG-TPP), dialysis to remove small molecular substances, open TPP-GSSG-TPP under the action of dithiothreitol (DTT), and form 2 molecules of TPP-GSH (Mito-GSH is TPP-GSH in the present invention). After dialysis, use preparative liquid phase and gradient elution to obtain pure product.

[0028] The prepared TPP-GSH molecular formula is as follows:

[0029]

[0030] 2. Take 1.2 grams of benzyl glutamate-N-carbonyl ring anhydride and dissolve it in 20 mL of dry nitrogen nitrogen dimethylformamide, mix it with amino PEG, and react at 38 degrees for 48 hours under nitrogen protection. The block copolymer of PEG and polybenzyl glutamate was obtained by dialysis, and the benzyl group was removed under the action of NaOH to form a PEG-PGA block copolymer. ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a mitochondria-targeted glutathione derivative nanopreparation and application thereof. The glutathione derivative nanopreparation provided by the invention can form targeted distribution of mitochondria, can well protect hydrogen peroxide induced (oxidative damage) cell apoptosis, has a relatively strong mitochondrial protection effect, and is found to have an in-vivo intraocular pressure control effect on a glaucoma experimental animal model.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a mitochondria-targeted glutathione derivative nano preparation and its application. Background technique [0002] Glutathione (GSH) widely exists in various animal and plant cells and can be used as a reducing agent to participate in the regulation of oxidation and reduction states in organisms, maintain intracellular oxidation and reduction balance, and promote biological macromolecules (lipids, protein , DNA, etc.) key components of oxidative damage repair. Mitochondria are the main organelles that generate free radicals in cells, and they are also the most vulnerable organelles to oxidative damage. The structure and function of trabecular cells are abnormal, which leads to the restriction of aqueous humor discharge and the formation of high intraocular pressure, which is the main pathological feature of glaucoma. As a kind of adversity, high intraocular pressure t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/34A61K47/18A61K9/08A61K47/36A61K47/26A61P27/06B82Y5/00B82Y40/00
CPCA61K47/34A61K47/18A61K9/08A61K9/0048A61K47/36A61K47/26A61P27/06B82Y5/00B82Y40/00Y02P20/55
Inventor 林森黄宝珊南开辉李青金佳惠谭婧阳
Owner WENZHOU MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com