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Medical application of phillygenin

The technology of forsythia aglycone and its application is applied in the field of medical use of forsythia aglycone in the preparation of drugs for preventing or treating pulmonary fibrosis, and can solve the problem of no anti-pulmonary fibrosis biological activity or clinical application research of forsythia aglycone. and other problems, to achieve the effect of improving treatment effect and quality of life, significant treatment effect, and reducing lung index

Pending Publication Date: 2021-09-28
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] But so far, there is no research on the anti-pulmonary fibrosis biological activity or clinical application of forsythiagenin

Method used

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  • Medical application of phillygenin
  • Medical application of phillygenin
  • Medical application of phillygenin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Forsythiagenin Injection

[0021]

[0022] Preparation process: mix the prescribed amount of propylene glycol and ethanol evenly, add forsythiagenin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain .

Embodiment 2

[0023] Example 2 Forsythiagenin Injection

[0024]

[0025]

[0026] Preparation process: add forsythiaside to the prescribed amount of polyethylene glycol-400 and ethanol, stir to dissolve, add 0.9% sodium chloride solution to 10L, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, that is have to.

Embodiment 3

[0027] Example 3 Forsythiagenin Injection

[0028]

[0029] Preparation process: mix the prescribed amount of ethanol and Tween-80 evenly, add forsythinin, stir to dissolve, add water for injection to 10L, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain.

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Abstract

The invention discloses application of phillygenin to preparation of a medicine for preventing or treating pulmonary fibrosis, and belongs to the field of medicine. The phillygenin disclosed by the invention is a traditional Chinese medicine monomer extracted from the traditional Chinese medicine fructus forsythiae; and animal tests show that the phillygenin has a remarkable prevention and treatment effect on pulmonary fibrosis. The phillygenin has the advantages of exact curative effect of resisting pulmonary fibrosis, low side effect and wide medical application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the medical application of forsythiagenin, in particular to the medical application of forsythinin in the preparation of medicines for preventing or treating pulmonary fibrosis. Background technique [0002] Pulmonary fibrosis is the final pathological change of a variety of interstitial lung diseases, characterized by long-term diffuse alveolitis, excessive proliferation of fibroblasts, and subsequent excessive deposition of extracellular matrix, which gradually replaces normal lung tissue, eventually causing Lung dysfunction, the patient may die from respiratory failure. Pulmonary fibrosis can be roughly divided into two categories: known causes (such as radiation, drugs, silicosis, etc.) and unexplained causes (such as idiopathic pulmonary fibrosis). Studies have shown that various factors such as pathogenic microorganisms, dust, drugs, and chemical agents can induce pulmonary fibrosis,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/34A61P11/00
CPCA61K31/34A61P11/00
Inventor 张贵民潘丽红李欣
Owner LUNAN PHARMA GROUP CORPORATION
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