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Mangiferin extraction and separation method

A separation method and technology of mangiferin, applied in the direction of organic chemistry, can solve the problems of denaturation and inactivation of mangiferin, instability of mangiferin, low economic benefit, etc., and achieve the effect of short processing time, low cost and energy saving

Pending Publication Date: 2021-09-24
蒙汉富
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Part of the process is complicated to operate, and a large amount of solvent is required for elution, which is easy to cause harm to the operator, and the cost of the solvent is high
In addition, the preparation period of most processes is long, the recovery rate is low, and the economic benefit is low
In other extraction processes, mangiferin is unstable under acidic or alkaline conditions. If acid extraction or alkaline extraction is used, most mangiferin may be denatured and inactivated during the preparation process.

Method used

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  • Mangiferin extraction and separation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A method for extracting and separating mangiferin, comprising the steps of:

[0028] (1) Put 1 kg of mango leaves into a high-pressure tank for 2 minutes after crushing, keep the pressure in the tank at 20 MPa, and the temperature in the tank at 25 °C, and then release the pressure to normal pressure within 0.3 s.

[0029] (2) Take out the mango leaf of step (1), add 3L ethyl acetate, and pass into micro-nano bubbles with a diameter of 200nm, seal and soak for 3h, then shake for 10min, filter with a 200-mesh filter screen, and extract repeatedly 3 times, Every time the micro-nano bubbles are supplemented in the mixed material, so that the number of micro-nano bubbles contained in every liter of ethyl acetate is 10.0×10 7 until the green color of the extract basically disappears, take the mango leaf residue.

[0030] (3) Percolate the mango leaf residue in step (2) by using an aqueous acetone solution with a volume fraction of 60%, combine the percolation solution, conc...

Embodiment 2

[0034] A method for extracting and separating mangiferin, comprising the steps of:

[0035] (1) Put 1 kg of mango leaves into a high-pressure tank after being crushed for 5 minutes to keep the pressure in the tank at 19 MPa and the temperature in the tank at 23 °C, and then release the pressure to normal pressure within 0.3 s.

[0036] (2) Take out the mango leaves of step (1), add 3.1L ethyl acetate, and pass into micro-nano bubbles with a diameter of 500nm, seal and soak for 2.8h, then shake for 15min, filter with a 200-mesh filter screen, and repeatedly extract 3 Every time, the micro-nano bubbles are added to the mixed material, so that the number of micro-nano bubbles contained in each liter of ethyl acetate is 8.5 × 10 7 until the green color of the extract basically disappears, take the mango leaf residue.

[0037] (3) Percolate the mango leaf residue in step (2) by using an aqueous acetone solution with a volume fraction of 65%, combine the percolation solution, conce...

Embodiment 3

[0041] A method for extracting and separating mangiferin, comprising the steps of:

[0042] (1) Put 1kg of mango leaves into a high-pressure tank after being crushed for 8 minutes to keep the pressure in the tank at 17MPa and the temperature in the tank at 21°C, and then release the pressure to normal pressure within 0.2s.

[0043] (2) Take out the mango leaf of step (1), add 3.2L ethyl acetate, and feed into micro-nano bubbles with a diameter of 5 μm, seal and soak for 2.5 hours, then shake for 12 minutes, filter with a 200-mesh filter screen, and repeatedly extract 2 Every time, the micro-nano bubbles are added to the mixed material, so that the number of micro-nano bubbles contained in each liter of ethyl acetate is 6.0×10 7 until the green color of the extract basically disappears, take the mango leaf residue.

[0044] (3) Percolate the mango leaf residue in step (2) with a 70% ethanol aqueous solution, combine the percolation solution, concentrate at 45° C., remove ethan...

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Abstract

The invention discloses a mangiferin extraction and separation method. The method comprises the steps of raw material crushing, raw material high-pressure pressure maintaining, ethyl acetate degreasing, percolation, methanol washing, ethanol washing and the like. According to the extraction and separation method disclosed by the invention, mangiferin with relatively high purity can be obtained only by adopting several simple extraction and separation means without treatment such as elution and the like, wherein the operation is simple and convenient, and the cost is greatly reduced. The extraction method provided by the invention can be used for respectively obtaining a crude mangiferin product with the purity of 66.0-68.2% and a pure mangiferin product with the purity of 95.0-96.6%, and has better extraction and purification effects.

Description

technical field [0001] The invention relates to the technical field of plant extraction, and more specifically relates to a method for extracting and separating mangiferin. Background technique [0002] Mangiferin (mangiferin) is a carbon ketone glycoside of tetrahydroxypyrrole, with the molecular formula C19H18O11, which is widely found in many plants such as mango, Anemarrhena, Capillaris, Swertia, almond and so on. In the Chinese Pharmacopoeia and the quality standards of various Chinese medicinal materials and Chinese patent medicines, the content of mangiferin is widely used as a quality control indicator. Modern medical research has proved that mangiferin has various pharmacological effects such as anti-oxidation, anti-inflammation, anti-radiation, prevention and treatment of skin aging, lowering blood sugar, lowering uric acid, anti-tumor, and immune regulation, and has a very high development and utilization prospect. [0003] At present, mangiferin in the market is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D407/04
CPCC07D407/04
Inventor 戴丽琼苏伟政张世学莫川献潘长沛洪中吉蒙汉富
Owner 蒙汉富
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