Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of pinoresinol in preparation of medicine for inhibiting thrombosis

A technology of medicine and application, which is applied in the field of preparation of antithrombosis drug of pinoresin, can solve the problem of thrombus formation of pinoresin that has not been seen yet, achieve good application prospects, significantly relax blood vessels, and excellent effect of inhibiting thrombus formation

Pending Publication Date: 2021-09-17
SHAANXI UNIV OF CHINESE MEDICINE
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although pinoresin has the above-mentioned biological activity, it has not been seen that pinoresin is used to inhibit thrombosis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of pinoresinol in preparation of medicine for inhibiting thrombosis
  • Application of pinoresinol in preparation of medicine for inhibiting thrombosis
  • Application of pinoresinol in preparation of medicine for inhibiting thrombosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1, pinoresin

[0033] (1) Preparation of Huanghuayoudiancao ethyl acetate extract

[0034] Take Huanghuayoudiancao (10.0kg) picked in Zhashui County, Shaanxi Province in 2018, dry and pulverize, extract 4 times with 80% methanol impregnation method at room temperature, and use 4.5 times the amount of 80% methanol for each extraction (that is, every 1kg Huanghuayoudiancao, add water 4.5L), the extraction time is 3, 5, 7, 7 days in turn. After extraction, the filtrates were combined, methanol was recovered under reduced pressure, and concentrated to obtain 495.0 g of methanol extract. Disperse the methanol extraction extract in water, extract 5 times with ethyl acetate to obtain ethyl acetate phase, and concentrate under reduced pressure to obtain ethyl acetate extract.

[0035] (2) Separation of pinoresin in Huanghuayoudiancao ethyl acetate extract

[0036] Dissolve 160.0g of ethyl acetate extract with 60mL of 100% methanol. After the sol...

Embodiment 2

[0038] Embodiment 2, function experiment of pinoresin inhibiting thrombus formation

[0039] (1) Preparation of the main solution

[0040] Krebs-Henseleit K-H (mmol / L) buffer (hereinafter referred to as K-H buffer): Weigh 6.903g NaCl, 0.358g KCl, 2.1g NaHCO 3 , 0.163g KH 2 PO 4 , 0.278g CaCl 2 , 0.144g MgSO 4 , 1.938g D-glucose, dilute to 1L with deionized water, pH=7.4.

[0041] High K + K-H buffer (hereinafter referred to as high K + K-H buffer): weigh 3.674g NaCl, 4.470g KCl, 2.1gNaHCO 3 , 0.163g KH 2 PO 4 , 0.278g CaCl 2 , 0.144g MgSO 4, 1.938g D-glucose, dilute to 1L with deionized water, pH=7.4.

[0042] (2) Preparation of vascular ring

[0043] a. Experimental animals

[0044] SD rats, 20, weighing 200.00-250.00g, male, were provided by Dashuo Experimental Animal Center in Chengdu, Sichuan, license number SCXK (Sichuan) 2020-030. The experimental animals were kept in the Pharmacology Experimental Animal Laboratory of the School of Pharmacy, Shaanxi Univer...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Weightaaaaaaaaaa
Login to View More

Abstract

The invention provides application of pinoresinol in preparation of a medicine for inhibiting thrombosis, and relates to the field of chemical medicines. Specifically provided is the application of a compound shown by formula I, or a salt thereof, or a solvate thereof, or a hydrate thereof, or a prodrug thereof in the preparation of the medicine for inhibiting thrombosis. The compound shown by the formula I is preferably pinoresinol. Researches find that the compound pinoresinol extracted from t. maculata machride can be used for inhibiting vasoconstriction and has a remarkable effect of relaxing blood vessels. Meanwhile, the compound pinoresinol has an inhibiting effect on thrombosis, the thrombosis inhibiting effect of low-dose pinoresinol is better than that of high-dose pinoresinol, the thrombosis inhibiting rate is as high as 76.92%, the excellent thrombosis inhibiting effect is achieved while the medicine using dose is reduced, and the medicine using safety is improved. The compound pinoresinol can be used for preparing the medicine for inhibiting thrombosis, is used for preventing or treating thromboembolic diseases, and has a good application prospect.

Description

technical field [0001] The invention relates to the field of chemical medicines, in particular to the use of pinoresin in the preparation of medicines for inhibiting thrombus formation. Background technique [0002] At present, the incidence of thromboembolic diseases is higher than that of various cardiovascular diseases, which has constituted a serious hazard to human life and health. Pathological studies have shown that its pathogenesis is related to the function of the blood vessel, which is mainly manifested in that when the vascular endothelial function is damaged, it will lead to the disorder of blood coagulation and fibrinolytic system, and promote the formation of atherosclerotic plaque. Under the action of various inducements, Cause atherosclerotic plaque to fall off, form thrombus, block blood vessels, and lead to thromboembolic diseases. Thromboembolic disease is a serious threat to human life and health, and its incidence rate ranks first among various diseases...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/343A61P7/02A61P9/10A61P11/00A61P1/00
CPCA61K31/343A61P7/02A61P9/10A61P11/00A61P1/00A61K36/896
Inventor 孙静王赟泽
Owner SHAANXI UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com