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Preparation process of natural extract

A technology of natural extracts and extracts, which is applied in the field of preparation technology of natural extracts, can solve problems such as high production costs, easy rebound, and complicated processes, and achieve the effects of reducing alcohol consumption, simplifying efficiency issues, and shortening process time

Pending Publication Date: 2021-08-31
正当年医药科技(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, many natural extracts have poor compressibility and are prone to rebound after tableting. They are not suitable for dry granulation or direct compression process. We can only use complicated wet granulation process; however, the production method of wet process is backward and the process is complicated. , the production cost is high, and there is a possibility of secondary pollution in the production process, and the product quality is unstable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Preparation process of Lycium barbarum polysaccharide granules:

[0046] Step 1) Put 50kg Lycium barbarum polysaccharide into a high-speed mixer, the mixing speed is 100rpm, the shearing speed is 1500rpm, and the mixing time is 5min;

[0047] Step 2) Add 11.33kg of alcohol into the wetting agent atomizer; the amount of alcohol added is calculated according to the following method.

[0048] The quality of alcohol is W, the raw material total amount of Lycium barbarum polysaccharide is Z, the moisture content of material is X, and alcohol concentration is Y, and W, X, Y and Z satisfy following calculation formula W=Z(5%-X) / (1 -Y), the speed W / 10 (kg / min) of alcohol atomization adding, wherein, the alcohol concentration Y is 85wt%.

[0049] Step 3) Set the speed of the high-speed mixer to 14rpm, and the mixing time to 10min, so that the alcohol and the material are evenly mixed.

[0050]Step 4) After step 3) is completed, the granulation is completed with dry granulation...

Embodiment 2

[0052] Preparation process of corn polypeptide granules:

[0053] Step 1) put 50kg of corn polypeptide into a high-speed mixer, the mixing speed is 100rpm, the shearing speed is 1500rpm, and the mixing time is 5min;

[0054] Step 2) Add 10kg of alcohol into the wetting agent atomizer; the amount of alcohol added is calculated according to the following method.

[0055] The quality of alcohol is W, the total amount of corn polypeptide raw materials is Z, the moisture content of the material is X, and the alcohol concentration is Y. W, X, Y and Z satisfy the following calculation formula W=Z(5%-X) / (1 -Y), the speed W / 10 (kg / min) of alcohol atomization adding, wherein, alcohol concentration Y is 90wt%.

[0056] Step 3) Set the speed of the high-speed mixer to 14rpm, and the mixing time to 10min, so that the alcohol and the material are evenly mixed.

[0057] Step 4) After step 3) is completed, dry granulation equipment is used to complete granulation to obtain corn polypeptide ...

Embodiment 3

[0059] Preparation process of wheat polypeptide granules:

[0060] Step 1) Put 50kg of wheat polypeptide into a high-speed mixer, the mixing speed is 100rpm, the shearing speed is 1500rpm, and the mixing time is 5min;

[0061] Step 2) Add 7.5kg of alcohol into the wetting agent atomizer; the amount of alcohol added is calculated according to the following method.

[0062] The quality of alcohol is W, the total amount of wheat polypeptide raw materials is Z, the moisture content of the material is X, and the alcohol concentration is Y. W, X, Y and Z satisfy the following calculation formula W=Z(5%-X) / (1 -Y), the speed W / 10 (kg / min) of alcohol atomization adding, wherein, alcohol concentration Y is 90wt%.

[0063] Step 3) Set the speed of the high-speed mixer to 14rpm, and the mixing time to 10min, so that the alcohol and the material are evenly mixed.

[0064] Step 4) After step 3) is completed, dry granulation equipment is used to complete granulation to obtain wheat polypep...

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Abstract

The invention relates to the field of pharmaceutical preparations, in particular to a preparation process for single components or compositions of polypeptides, polysaccharides and natural Chinese herbal medicine extracts, which comprises the following steps of: mixing at a high speed, atomizing and adding alcohol, fully and uniformly mixing, and dry granulating. The granulated particles can be used for tabletting, filling capsules or filling composite film bags. Compared with a traditional dry granulating process, the granulating process of the invention can solve the problem of single components or compositions of polypeptides, polysaccharides and natural Chinese herbal medicine extracts which are not suitable for dry granulating, and compared with a traditional wet granulating process, the processing steps can be simplified, soft materials are not needed, heating and drying are not needed, the cost is reduced, the productivity is improved, the materials can be effectively prevented from being agglomerated in the granulating process, and therefore the granulating process has the advantages of low cost, high productivity and high efficiency.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a preparation process of natural extracts. Background technique [0002] In the field of pharmaceuticals and food, common preparation processes include dry granulation, wet granulation and direct compression processes, which are often used in the production of pharmaceutical tablets, powders, hard capsules and granules; [0003] Dry granulation is to mix the drug and diluent, disintegrant, lubricant, etc. according to the mixing method of the powder, and then process it 1-3 times by rolling or open rubber mixing machine, and press it into a sheet with the required hardness, and then use it The method of crushing into granules by a swing granulator. The special machine for dry granulation, such as the Chitsonator machine produced in the United States, is fast and stable, and can continuously compact the material block and make granules after sieving. In some tablets, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/20A61K9/48A61K31/715A61K36/488A61K38/01A23P10/20A23P10/28A23P10/30
CPCA61K9/16A61K9/1682A61K9/2095A61K31/715A61K36/488A61K38/011A23P10/20A23P10/28A23P10/30
Inventor 张志勇
Owner 正当年医药科技(广州)有限公司
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