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Application of mitoquinone in the preparation of medicaments for preventing and/or treating sports injuries

A technology for inhibiting damage and drugs, applied in the application field of drugs, to achieve the effect of reducing calcification volume, improving biomechanical properties, and increasing elastic modulus

Active Publication Date: 2022-03-25
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report on the prevention and / or treatment of sports injuries with Mitoquinone

Method used

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  • Application of mitoquinone in the preparation of medicaments for preventing and/or treating sports injuries
  • Application of mitoquinone in the preparation of medicaments for preventing and/or treating sports injuries
  • Application of mitoquinone in the preparation of medicaments for preventing and/or treating sports injuries

Examples

Experimental program
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Effect test

Embodiment 1

[0050]1. Mitoquinone improves the biomechanical properties of mice after Achilles tendon rupture injury: Dilute Mitoquinone (product number: GC30416) purchased from Glpbio Company to 4 mg / mL with sterile DMSO for use; take 30 8-week-old C57BL / 6-year-old The rats were randomly divided into two groups, and the Achilles tendon amputation model was used to simulate tendon rupture. Hair removal and routine disinfection were performed. Under aseptic conditions, a longitudinal incision of about 1 cm was made on the skin of the right heel to expose the fascia and Achilles tendon. The plantar tendon and Achilles tendon were transected in the middle of the Achilles tendon, and the skin was sutured. Administration began on the second day after modeling (according to the dose of 2mg / Kg according to the body weight of the mice: the experimental group was injected with Mitoquinone (MitoQ), and the control group was injected with the same amount of DMSO. The specific scheme is shown in Table ...

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Abstract

The invention belongs to the technical field of medicines, and discloses the application of Mitoquinone in the preparation of medicines for preventing and / or treating sports injuries. The present invention discloses for the first time the application of Mitoquinone or its derivatives in the prevention and / or treatment of sports injuries. Mitoquinone and / or its derivatives can significantly improve the elastic modulus of damaged tissues and reduce the calcified volume of damaged tissues. By inhibiting The formation of damaged tissue calcification and / or the improvement of the biomechanical properties of the damaged tissue achieve the purpose of treating sports injuries, and can be used to prepare medicines for preventing and / or treating sports injuries.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of Mitoquinone in the preparation of medicines for preventing and / or treating sports injuries. Background technique [0002] Sports injuries are very common in daily life and sports, especially in the field of sports medicine. Of these, tendon injuries are the most common. Tendon calcification, as a common and serious complication after tendon injury, often occurs after surgical repair of tendon injury, or as a manifestation of chronic functional and structural disorders after tendon injury. The incidence of calcification after Achilles tendon rupture surgery is as high as 14%-62%, which can cause symptoms such as pain, tendon weakness, local edema, and limited mobility. At present, the pathogenesis of tendon calcification and how to prevent it are not clear, so there is no clear drug for the prevention and treatment of tendon calcification. [00...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/662A61P19/00A61P19/02A61P19/04
CPCA61K31/662A61P19/00A61P19/02A61P19/04
Inventor 张凯瑞李凯群余斌
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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