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Stimuli-responsive size-adjustable nano hydrogel drug delivery system and preparation method thereof

A nano-hydrogel, stimuli-responsive technology, used in drug delivery, condensation/addition reaction preparation of amino compounds, pharmaceutical formulations, etc. Reasonable design, low cost and broad application prospects

Inactive Publication Date: 2021-08-13
NANJING UNIV OF POSTS & TELECOMM
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] In recent years, with the attention of researchers on drug-loaded delivery systems, more and more nano-drug delivery systems have been designed to improve drug delivery rates. However, most drug delivery systems, whether nano-drug delivery systems or hydrogel-based The in situ injection delivery system of glue has its own disadvantages, for example, it is difficult for anticancer drugs to reach the inside of the tumor and it is difficult to achieve deep treatment

Method used

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  • Stimuli-responsive size-adjustable nano hydrogel drug delivery system and preparation method thereof
  • Stimuli-responsive size-adjustable nano hydrogel drug delivery system and preparation method thereof
  • Stimuli-responsive size-adjustable nano hydrogel drug delivery system and preparation method thereof

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Embodiment Construction

[0034] The present invention will be further described in detail below in conjunction with the examples.

[0035] Such as figure 1 As shown, this embodiment provides a stimuli-responsive nano-hydrogel drug delivery system with adjustable size, and the nano-hydrogel drug delivery system is a nano-hydrogel loaded with an anticancer drug DOX. The loading of the anticancer drug DOX is mainly through electrostatic adsorption, and the preparation of the nano hydrogel is divided into two parts. Firstly, monomeric acrylic acid and N-isopropylacrylamide were prepared by reflux precipitation method to prepare stimuli-responsive size-tunable nano-hydrogels, and then connected to AT by EDC / NHS to form polymer nano-hydrogels.

[0036] figure 2 It is the TEM test picture of the nano-hydrogel PAN NG (left) and AT-PAN NG (right) synthesized in the example of the present invention. It can be seen from the test results that the prepared nano-hydrogel has uniform particle size and average siz...

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Abstract

The invention provides a stimuli-responsive size-adjustable nano hydrogel drug delivery system and a preparation method thereof. The drug delivery system aims to meet the requirements that single drug treatment is easy to generate drug resistance, drugs are difficult to enter tumor and the like. The preparation method comprises the following steps of synthesizing nano-hydrogel from monomer acrylic acid and monomer N-isopropyl acrylamide through a reflux precipitation method, promoting connection of aniline tetramer to the nano-hydrogel through EDC / NHS, and loading an anti-cancer drug through electrostatic adsorption to form the nano-hydrogel drug delivery system. The temperature-sensitive material N-isopropyl acrylamide in the drug delivery system enables the nano-hydrogel to have a temperature-controlled size-adjustable property, and the excellent photo-thermal and photo-acoustic imaging property of aniline tetramer is combined, so that the stimuli-responsive size-adjustable nano-hydrogel drug delivery system can realize image-guided photo-thermal / chemotherapy / deep treatment combined treatment.

Description

technical field [0001] The invention relates to a stimuli-responsive size-adjustable nanometer hydrogel drug delivery system and a preparation method thereof, belonging to the technical field of drug carrier basic material synthesis. Background technique [0002] In recent years, with the attention of researchers on drug-loaded delivery systems, more and more nano-drug delivery systems have been designed to improve drug delivery rates. However, most drug delivery systems, whether nano-drug delivery systems or hydrogel-based The in situ injection delivery system of glue has its own disadvantages, for example, it is difficult for anticancer drugs to reach the inside of the tumor and it is difficult to achieve deep treatment. Therefore, it will be of great significance to design a drug delivery system that can promote the drug into the tumor for deep treatment. [0003] When designing a drug delivery system that can achieve deep treatment, we studied the process of nanomateria...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/58A61K47/59A61K47/69A61K31/704A61K41/00A61P35/00A61K49/22C07C209/60C07C209/84C07C211/55
CPCA61K9/06A61K47/58A61K47/59A61K47/6903A61K31/704A61K41/0052A61P35/00A61K49/221A61K49/226C07C209/60C07C209/84A61K2300/00C07C211/55
Inventor 杨文静胡亚琴梁丽君王雨馨汪联辉
Owner NANJING UNIV OF POSTS & TELECOMM
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