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Oral care compositions and methods for the same

A composition and oral technology, applied in oral care composition and its field, can solve the problems of reducing effectiveness and reducing sensitivity, and achieve the effect of reducing tooth sensitivity

Pending Publication Date: 2021-08-06
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these conventional methods may often require several days or weeks of treatment before any significant reduction or improvement in sensitivity is observed
Additionally, conventional methods may utilize occlusive agents in dentifrices (eg, toothpaste) that can be rinsed off throughout the day, reducing effectiveness

Method used

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  • Oral care compositions and methods for the same
  • Oral care compositions and methods for the same
  • Oral care compositions and methods for the same

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0071] The sensitivity-reducing efficacy of exemplary film-forming compositions (1)-(3) was evaluated in vitro. In particular, the efficacy of film-forming compositions (1)-(3) to insert or seal dentinal tubules was evaluated. Test or exemplary film-forming compositions (1 )-(3) were prepared by combining ingredients / components according to Table 1 . Specifically, the ingredients / components of each of the test film-forming compositions (1)-(3) were combined or otherwise contacted with each other in a rotary mixing jar and mixed at about 3540 rpm for about 5 minutes or until a homogeneous suspension is obtained.

[0072] Table 1 Test film-forming compositions (1)-(3)

[0073]

[0074] Human molars were sliced ​​and ground to prepare dentin sections. To evaluate the efficacy of film-forming compositions (1)-(3), each film-forming composition was applied directly to the dry dentin surface of individual human dentin sections with a soft nail polish-type brush. These were ke...

example 2

[0079] The exemplary film-forming composition of Example 1 (1) was evaluated on dentin sections against a commercial toothpaste for sensitivity (i.e. Sensitive Pro-Relief TM) in combination with the efficacy of maintaining, promoting and / or enhancing closure of dentinal tubules. The studies were performed by preparing slurries of commercial toothpaste and phosphate buffered saline (PBS) in a 3:1 ratio. The slurry was applied to the dentin surface by brushing with a soft nail polish type brush for 30 seconds, followed by PBS treatment for 15 minutes. Repeat this procedure 5 times. Half of the dentin sections received a one-time treatment with the exemplary film-forming composition (1 ) and the other half did not. After treatment, acid (i.e., Coca ) to excite all human dentin sections for one minute. Confocal images were acquired before any treatment (baseline), after treatment with commercial toothpaste, exemplary film-forming composition (1 ), and after acid challenge. ...

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Abstract

The present invention provides film forming compositions and methods for occluding dentin tubules of teeth to treat dentinal hypersensitivity of the teeth. The film forming compositions may include a hydrophobic copolymer, a rosin, and an orally acceptable solvent. The hydrophobic copolymer may include an acrylate / octylacrylamide copolymer, such as 2-propenoic acid, 2-methyl-, 2- methylpropyl ester, polymer with 2-propenoic acid and N-(1, 1,3,3- tetramethylbutyl)-2- propenamide. Methods for treating dentinal hypersensitivity may include contacting the film forming composition with surfaces of the teeth.

Description

Background technique [0001] Dentin or dentin hypersensitivity is a common clinical condition associated with the exposure of the dentin surface of teeth. Dentin contains numerous pores, or dentinal tubules, that extend from the outer surface of the tooth to the inner nerve of the tooth. Thus, exposure of dentin often results in increased tooth sensitivity to external stimuli (eg, temperature, pressure, etc.). In view of the foregoing, conventional oral care products or compositions thereof often attempt to numb nerves or incorporate fillers or occlusives to improve tooth sensitivity. For example, conventional oral care compositions may incorporate fillers or sealants to physically seal or fill dentinal tubules, thereby shielding the nerves from external stimuli. However, these conventional methods may often require several days or weeks of treatment before any significant reduction or improvement in sensitivity is observed. Additionally, conventional methods may utilize occ...

Claims

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Application Information

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IPC IPC(8): A61K8/44A61Q11/00A61K8/73A61K8/81
CPCA61K8/44A61K8/731A61K8/8152A61K8/8158A61Q11/00
Inventor 董蓉伊雷妮·彼得鲁帕洛马·皮门塔斯泰西·拉文德希拉·皮尔希
Owner COLGATE PALMOLIVE CO
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