Bioreactor for artificial liver

Abstract

The invention discloses a bioreactor for an artificial liver, and the bioreactor comprises a circular glass cylinder sealed by covers at the two ends, and a plurality of hollow fiber tubes made of hollow fiber membranes are arranged in the center in the circular cylinder; the blood inlet pipe is communicated with one ends of all the hollow fiber pipes, the blood outlet pipe is communicated with the other ends of all the hollow fiber pipes, the nutrient solution inlet pipe and the nutrient solution outlet pipe are communicated with the peripheral gap, a plurality of first rod type electrodes are fixed to the inner wall of the circular cylinder, and a second rod type electrode is fixed to the centers of the hollow fiber pipes. One end of each first rod-type electrode is electrically connected with the negative electrode of the battery, one end of each second rod-type electrode is electrically connected with the positive electrode of the battery, the first rod-type electrodes are uniformly distributed along the circumference of the inner wall of the circular glass cylinder, and an electric field which uniformly radiates in the radial direction is formed between the first rod-type electrodes and the second rod-type electrodes. The bioreactor of the artificial liver can fully remove protein binding toxins in blood, and the service life of the bioreactor of the artificial liver is prolonged.

Description

technical field [0001] The invention relates to the technical field of biomedical devices, in particular to a bioreactor for an artificial liver. Background technique [0002] The usual meaning of an artificial liver is to use pressure to drive the patient's blood through the extracorporeal artificial liver system through an extracorporeal mechanical device or physical and chemical device, and take on the role of temporarily assisting or completely replacing the severely diseased liver, removing various harmful substances, compensating Metabolic function of the liver until the body's own liver function is restored or liver transplantation is performed. [0003] The bioreactor of the artificial liver is the part used to remove toxins in the artificial liver system, and is the core of the artificial liver system. The bioreactor of the artificial liver in the prior art includes a circular cylinder sealed by covers at both ends. There are several hollow fiber tubes made of holl...

AI Technical Summary

Problems solved by technology

However, in the actual use process, it was found that the effect was not obvious, and the protein-binding toxin would still accumulate and adsorb on the surface of the hollow fiber membrane that constitutes the hollow fiber tube, blocking the small through holes of the fiber membrane, and the small pores were blocked so that the protein-binding toxin could not From the hollow fiber tube, that is, the inner cavity, to the peripheral space outside the hollow fiber tube, that is, the outer cavity, which affects the detoxification efficiency and service life of the bioreactor of the artificial liver, that is, the patients with liver disease have passed the bioreactor of the existing artificial liver. After artificial liver system treatment, there are still some toxins (mainly protein-bound toxins) that cannot be removed from the blood, so that the detoxification effect of the artificial liver system is not sufficient enough to achieve the expected therapeutic effect

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