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Nano-drug-iodine oil homogeneous preparation as well as preparation method and application thereof

A technology of nano-medicine and iodized oil, which is applied in the direction of nano-medicine, nanotechnology, nanotechnology, etc., can solve the problems of unfavorable thermal radiation combined therapy and achieve easy-to-achieve effects

Active Publication Date: 2021-07-27
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The object of the present invention is to overcome the deficiencies in the prior art, a kind of nano-medicine-iodol homogeneous preparation and preparation method thereof are provided, and its therapeutic effect on liver cancer The application of embolization / thermal radiation combined therapy medicament or embolic agent solves the problem of unfavorable thermal radiation combined therapy after long-term embolization in the above-mentioned background technology, and also solves the problem of continued utilization of iodized oil

Method used

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  • Nano-drug-iodine oil homogeneous preparation as well as preparation method and application thereof
  • Nano-drug-iodine oil homogeneous preparation as well as preparation method and application thereof
  • Nano-drug-iodine oil homogeneous preparation as well as preparation method and application thereof

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Embodiment 1

[0032] 1. A kind of Fe in this embodiment 3 o 4 - the preparation method of lipiodol homogeneous preparation, comprises the following steps ( figure 1 ):

[0033] (a) First, pretreatment prepares iron oleate complex, 5.4g FeCl 3 ·6H 2 O and 18.3g of sodium oleate were added to a mixed solution of 40mL of ethanol, 30mL of water and 70mL of hexane, and reacted at 70°C for 4h to separate the iron oleate complex; then the iron oleate complex and oil The acid was added to 1-octadecene, and the addition amounts of iron oleate complex, oleic acid, and 1-octadecene were 18g, 2.9g, and 100g respectively, and the temperature was steadily increased to 320°C and kept at 0.5 h to obtain brown-black oleic acid surface-modified Fe 3 o 4 nanoparticles;

[0034] (b) Take 2mg Fe 3 o 4 Add nanoparticles and 2mL lipiodol into the reaction kettle together, inject carbon dioxide into the reaction kettle, pressurize to 20Mpa to form a supercritical environment, and continue stirring for h; ...

Embodiment 2

[0041] The difference between embodiment 2 and embodiment 1 is:

[0042] 1. This embodiment provides a method for preparing AuNPs-iodol homogeneous embolic agent, comprising the following steps:

[0043] (a) First, AuNPs were prepared using chloroauric acid and sodium borohydride, and the prepared AuNPs and oleylamine were added to ethanol at concentrations of 2 mg / mL and 1 mg / mL, and stirred for 6 hours to obtain AuNPs nanoparticles modified on the surface of oleylamine;

[0044] (b) Take 1mg of Fe3O4 nanoparticles and 2mL of iodized oil and add them to the reactor, inject carbon dioxide into the reactor, pressurize to 15Mpa to form a supercritical environment, and continue to stir for 1h;

[0045] (c) After decompression, the AuNPs-iodol homogeneous preparation was collected from the reactor.

[0046] 2. The embolization combined therapy based on AuNPs-iodol homogeneous embolic agent includes the following steps:

[0047] (a) AuNPs-lipiodol homogeneous embolic agent is ins...

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Abstract

The invention discloses a nano-drug-iodine oil homogeneous preparation as well as a preparation method and an application thereof. The nano-drug-iodized oil homogeneous preparation is a homogeneous preparation formed by uniformly dispersing a functional nano-drug in an iodized oil injection by using supercritical carbon dioxide, wherein the concentration of the functional nano-drug in the iodized oil is 0.1-20 mg / mL; the functional nano-drug has magnetocaloric performance or photothermal performance, and the surface of the functional nano-drug is modified with oleic acid or oleylamine. The nano-drug-iodized oil homogeneous preparation disclosed by the invention has better dispersity, and the nano-drug can be stably dispersed in the iodized oil during long-time storage without coagulation. After the nano-drug is intervened into a tumor area, the combined effect of embolism treatment and exogenous excitation heat radiation treatment can be achieved.

Description

technical field [0001] The invention specifically relates to a nano-medicine-iodol homogeneous preparation and a preparation method thereof, and its application in liver cancer embolization / thermal radiation combined therapeutic agents or embolization agents. Background technique [0002] In recent years, nanotechnology has been widely recognized by the public, and its special properties have also achieved applications in various disciplines. At the same time, nanomaterials are not only used in drug delivery systems, but also widely used in biodiagnosis and nanomedicine due to their excellent optical, electrical, magnetic, and acoustic properties. At present, a variety of nano-medicines have been applied in clinical diagnosis and treatment, and have achieved good results. However, current nanomedicines have problems such as low enrichment in the lesion area, toxicity in vivo, and easy clearance by the immune system. Therefore, rational, efficient, and safe delivery routes ...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/18A61K47/12A61P35/00B82Y5/00B82Y40/00A61J3/08A61N5/06A61N2/00
CPCA61K41/0052A61K47/18A61K47/12A61P35/00B82Y5/00B82Y40/00A61J3/08A61N5/06A61N5/0625A61N2/002Y02P20/54
Inventor 刘刚楚成超代奇轩许大壮程红伟
Owner XIAMEN UNIV
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