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Mask for enhancing prevention of infectious disease transmission and use method

A technology of infectious diseases and masks, applied in the fields of application, biochemical treatment of enzymes/microbes, protective clothing, etc., can solve the problems of easy variation, poor vaccine effectiveness, etc., and achieve the effect of reducing unexpected situations

Pending Publication Date: 2021-07-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The new coronavirus is an RNA virus, it is easy to mutate, and the vaccine produced is not 100% effective

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Weigh 1-2 grams of cyanogen bromide directly in a fume hood with a commercially available two-layer gauze or three-layer gauze mask, add an appropriate amount of aqueous solution, add 2-5ml of dimethyl sulfoxide, and add 1-5g of sodium hydroxide , react at room temperature for 1 hour, remove the solution by suction filtration, and then add 1% trypsin solution to react at room temperature for 2 hours. Immobilized trypsin was prepared by washing and drying.

[0020] During use, the trypsin-treated solid-phase enzyme mask (in the outer layer) is used in combination with the medical surgical mask (inner layer), and is sprayed in combination with a spray bottle to maintain the suitable pH condition of the trypsin. At a suitable pH and temperature, trypsin degrades the spike protein on the surface of the virus, making it lose its ability to bind to the virus receptor in the host, thereby protecting the host from virus infection.

Embodiment 2

[0022] Directly weigh 1-2 grams of cyanogen bromide in a fume hood with a commercially available common three-layer gauze mask, add an appropriate amount of aqueous solution and add dimethyl sulfoxide 2 -5ml, add 1-5g sodium hydroxide, react at room temperature for 1 hour, remove the solution by suction filtration, then add 1% trypsin solution and react at room temperature for 2 hours. Immobilized trypsin was prepared by washing and drying.

[0023] When in use, the trypsin-treated solid-phase enzyme gauze two or three layers are cut to an appropriate size and sewed on the outer layer of the medical surgical mask, so that the air enters the human body and first contacts with the trypsin on the gauze, and combines with the spray bottle The outer surface of the mask is sprayed to maintain a suitable pH condition for trypsin, so that trypsin can function best under alkaline conditions. At a suitable pH and temperature, trypsin degrades the spike protein on the surface of the vir...

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PUM

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Abstract

The invention relates to a mask for enhancing prevention of infectious disease transmission and a use method. The method comprises the following steps of introducing gauze cellulose hydroxyl into an activated cyano group through cyanogen bromide under the reaction conditions of alkalinity, dimethyl sulfoxide and the like, carrying out covalent coupling on the activated cyano group and amino in trypsin, and then preparing immobilized trypsin. According to a solid-phase enzyme technology, the trypsin is fixed to the gauze mask, a dilute alkaline solution is sprayed to gauze through a small spraying bottle, enzyme is in a moist environment, solid-phase pancreatin is in the optimum working pH range, and exhaled air enables the pancreatin to work at a proper temperature. The pancreatin destroys spike protein of protein on the pathogen surface under the proper conditions, so that the spike protein cannot be combined with a virus receptor in the human body. Meanwhile, after a virus protection layer is damaged, nucleic acid of the virus protection layer is easily degraded by nuclease in air or exhaled by people, and then the virus protection layer is used in cooperation with the medical mask, so that the effect of preventing infectious diseases is improved.

Description

technical field [0001] The invention relates to immunology, solid-phase enzyme technology in immunology technology, and the field of infectious diseases, serves for epidemic prevention work, and reduces the harm of infectious diseases by blocking the way of infection. [0002] Background of the invention [0003] The new coronavirus is an RNA virus, which is prone to mutations, and the vaccines produced are not 100% effective. Therefore, people can only stay at home, reduce going out, wear masks when going out, and maintain social distance and other measures to cut off the transmission of infectious diseases. [0004] Controlling the way of transmission is also an effective means. For this reason, this invention is launched, hoping that human society will be helpful in slowing down the prevention and control of infectious diseases [0005] So I had to think of other ways. Note that the new coronavirus is not resistant to high temperature, sensitive to alcohol, and sensitive...

Claims

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Application Information

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IPC IPC(8): D06M16/00D06M15/15D06M13/345A41D13/11D06M101/06
CPCA41D13/1192D06M13/345D06M15/15D06M16/00D06M16/003D06M2101/06
Inventor 陈正贤闫菲郑联顺徐鑫焱刘双韩兴民冯佳威李怡卿
Owner ZHEJIANG UNIV
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