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Mask for epidemic prevention and using method

A technology of mask and oxidation method, which is applied to infectious diseases, solid-phase enzyme technology in immunology technology, and the field of immunology. It can solve the problems that vaccines are not effective, easy to mutate, etc., and achieve the effect of reducing accidents.

Pending Publication Date: 2021-07-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since the new coronavirus is an RNA virus, it is easy to mutate, and the vaccine produced is not 100% effective.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Dip a commercially available two-layer gauze or three-layer gauze mask directly into 0.05M NaIO 4 React in the solution at room temperature for 0.5h, rinse with distilled water to remove excess NaIO 4 , and then soak the gauze mask in 0.05MpH9.6 NaHCO containing 1-5% trypsin 3 -Na 2 CO 3 The coupling reaction was carried out overnight at 4°C in the solution, and 2-20mg / ml sodium borohydride was added the next day. At this time, many bubbles appeared on the gauze mask, that is, the hydrogenation reaction. After hydrogenation reaction for 0.5-2h, rinse with water to terminate the reaction. Immobilized trypsin is prepared after drying. This coupling technique has mild reaction conditions and does not lose the activity of the enzyme.

[0018] When in use, the trypsin-treated solid-phase enzyme mask (in the outer layer) is used in combination with the medical surgical mask (inner layer), and the outer surface of the mask of the solid-phase enzyme is sprayed a few times i...

Embodiment 2

[0020] Directly immerse a commercially available three-layer gauze mask in 0.05M NaIO 4 React 0.5h at room temperature in the solution, rinse with distilled water and remove excess sodium periodate (NaIO 4 ), and then soak the gauze mask in 0.05MpH9.6 NaHCO containing 1% trypsin 3 -Na 2 CO 3 The coupling reaction was carried out overnight at 4°C in the solution, and 2 mg of sodium borohydride was added the next day. At this time, many bubbles appeared on the gauze mask, that is, hydrogenation reaction. After hydrogenation reaction for 0.5-2h, rinse with water to terminate the reaction. After drying, the immobilized trypsin was prepared.

[0021] When using the trypsin-treated solid-phase enzyme gauze, cut two or three layers to an appropriate size and sew it on the outer layer of the medical surgical mask, so that the air enters the human body and first contacts the trypsin on the gauze, and then sprays it with a spray bottle , to maintain the appropriate pH conditions of...

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Abstract

According to the mask for epidemic prevention and the using method, glycosyl in gauze is oxidized by a sodium periodate oxidation method, glycosyl of cellulose in the gauze is oxidized into aldehyde groups, then covalent coupling is conducted on the aldehyde groups and amino groups in trypsin, a stable conjugate is generated through a hydrogenation reaction, and therefore the solid-phase trypsin gauze mask is prepared; and the gauze mask is combined with a medical surgical mask for use. When in use, the gauze immobilized enzyme is placed outside a common medical mask, trypsin is in direct contact with the outermost air, and a solution with the pH of 7.2-8.0 is sprayed to an outer surface of the trypsin gauze mask through a small spray bottle, so the trypsin is in full contact with new coronavirus, and the enzyme effect is played under the optimal pH condition. When a human body inhales the air treated by the enzyme, the content of live viruses in the air can be reduced, and a purpose of preventing and controlling epidemic diseases is achieved.

Description

technical field [0001] The invention relates to immunology, solid-phase enzyme technology in immunology technology, and the field of infectious diseases. It serves the epidemic prevention work and reduces the harm of infectious diseases by blocking the way of infection. [0002] Background of the invention [0003] Since the new coronavirus is an RNA virus, it is easy to mutate, and the vaccine produced is not 100% guaranteed to be effective. Therefore, people may take measures such as staying at home, reducing going out, wearing masks when going out, and maintaining social distance to isolate the transmission of infectious diseases and try to reduce the risk of infection. [0004] So I can only think of other ways, noting that the new coronavirus is not resistant to high temperature, sensitive to alcohol, and sensitive to trypsin. Maybe we can make some efforts in the way of transmission, maybe we can stop the spread of the virus. Considering the emergence of new coronavir...

Claims

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Application Information

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IPC IPC(8): A41D13/11A41D31/30C12N11/12C12N9/76D06B1/02
CPCA41D13/1192A41D31/30C12N9/6427C12N11/12C12Y304/21004D06B1/02
Inventor 陈正贤毛碧增杜雪洁郭萌萌闫菲谢婷高俊霞钱嘉辉
Owner ZHEJIANG UNIV
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