Composite nano-enzyme for tumor targeting as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of tumor treatment, and discloses a composite nano-enzyme for tumor targeting as well as a preparation method and application thereof. The composite nano-enzyme for tumor targeting is prepared from the following components of, in parts by mass, 6-8 parts of lactate oxidase, 3-5 parts of ribonucleic acid endonuclease, 3-6 parts of deoxyribonucleic acid endonuclease, 2-4 parts of human serum albumin, 1-3 parts of glutathione, 3-4 parts of ammonium ferrous sulfate and 1-2 parts of diazo diammonium salt contrast agent. The composite nano-enzyme prepared by the invention can effectively realize tumor penetration; meanwhile, the ammonium ferrous sulfate wrapped in the composite nano-enzyme has an oxygen carrying function, oxygen can be input into a tumor microenvironment, and tumor treatment is facilitated; and meanwhile, the preparation method of the composite nano-enzyme for tumor targeting is simple, no high-temperature or complex equipment or harsh reaction conditions are needed, and the prepared composite nano-enzyme for tumor targeting is uniform in texture and good in tumor treatment effect.

Description

technical field [0001] The invention belongs to the technical field of tumor treatment, and in particular relates to a composite nanozyme for tumor targeting, a preparation method and application thereof. Background technique [0002] At present, nanozymes are a class of nanomaterials with enzymatic properties discovered by Chinese scientists in recent years. As a new type of artificial mimetic enzyme, nanozyme has the advantages of economy, stability, and easy mass production. More importantly, nanozyme is a bifunctional or multifunctional molecule, which not only has catalytic activity, but also has nano Material-specific physical and chemical properties, such as magnetism, fluorescence, photothermal properties, etc. The emergence of nanozymes provides a new idea for the application of enzyme-catalyzed reactions in the diagnosis and treatment of diseases. [0003] Tumor therapy based on chemical kinetics is to use the enzymatic properties of nanozymes to generate hydroxy...

AI Technical Summary

Problems solved by technology

[0004] Through the above analysis, the existing problems and defects of the prior art are: the existing composite nanozyme for tumor targeting has poor enrichment effect at the tumor site, and the treatment effect is poor

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