Irrigation solution as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of medical treatment, and discloses a lavage fluid as well as a preparation method and application thereof, and the lavage fluid comprises the following components: normal saline, buffer alkali, potassium chloride, a sodium channel blocker and furosemide. The inventor carries out a large number of experiments in the earlier stage and accidentally finds that according to the technical scheme, due to the reasonable proportion and the combination of all the components, water-salt electrolyte and acid-base balance disorder of an organism caused by the fact that lavage fluid is absorbed or directly enters a circulating system can be effectively relieved or avoided, such as high chlorine acidosis, hypokalemia, high blood volume, decrease of oxygenation index and the like; therefore, the blood dilution is effectively avoided, postoperative BNP and troponin I (cTnI) levels are reduced, the anterior load of the heart and myocardial injury are relieved, pulmonary interstitial edema is relieved, the exchange function of the lung is protected, operation related complications are reduced, and postoperative rehabilitation of a patient is facilitated. The lavage fluid disclosed by the invention is widely applied to the surgical operation of continuous surgical field lavage, has a wide application prospect and is worthy of being vigorously popularized.

Description

technical field [0001] The invention belongs to the field of medical technology, and in particular relates to a lavage solution and a preparation method and application thereof. Background technique [0002] Percutaneous nephrolithotomy (PCNL) is currently the main minimally invasive procedure for the treatment of upper urinary tract stones. It has been widely used due to its advantages of less trauma, fewer complications, and high stone removal rate. During the PCNL process, a large amount of lavage fluid needs to be used to flush the renal pelvis and calyceal collecting system to ensure a clear view during the operation, and at the same time flush out the crushed stone debris to facilitate stone removal. The lavage fluid is reabsorbed into the circulation through the renal tubules, interstitium of the renal pelvis, venous reflux in the fornix of the calices, and lymphatic reflux of the renal pelvis, which may cause a series of physiological changes. In severe cases, respir...

AI Technical Summary

Problems solved by technology

However, the economic cost of sodium lactate Ringer's solution is relatively high, and a large amount of sodium lactate may increase the burden on the liver. If it exceeds the metabolic capacity of the liver, it can lead to lactic acidosis, resulting in increased anion gap and metabolic acidosis.

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