Compound taking heteroanthrone skeleton as core, and application thereof
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[0062] Example 1 Synthesis of Compound 10:
[0063]
[0064] 0.01 mol of intermediate D-1 and 0.012 mol of raw material E-1 plus 150 ml of toluene: ethanol = 2: 1 mixed solvent, 0.02 mol of potassium carbonate, add 0.0002 mol Pd after removal of oxygen (PPH) 3 ) 4 After 24 hours at 110 ° C under a nitrogen, the point plate is taken, and the reaction is carried out, cool, filtrate, and the filtrate is evaporated to evaporation. The coarse product is passed through the silicone column to obtain a compound 10; HPLC purity 98.97%, 88.7%; element analysis structure (C 38 Hide 22 N 2 O 2 Theoretical value: C, 84.74; H, 4.12; N, 5.20; test values: C, 84.75; H, 4.13; N, 5.21. LC-MS (M / Z): Theoretical Value: 538.17, measured value: 538.20.
[0065] Repeated Example 1 The preparation process was combined to synthesize the following target compound; the reaction conditions were the same, and the intermediate D and the raw material E listed in Table 1 were used.
[0066] Table 1
[0067] ...
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