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Novel anti-tumor application of seven-ingredient safflower prescription

An anti-tumor, new-purpose technology, applied in the direction of anti-tumor drugs, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of rare anti-tumor effects, reduce the immune function of the body, and induce liver cancer cells Apoptosis, the effect of reducing inflammatory response

Pending Publication Date: 2021-06-18
吴宗耀
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Qiwei Honghua Zhusheng Pills, a classic Tibetan medicine prescription, comes from the "Four Medical Classics-Discussion Collection". The whole prescription of Tibetan medicine and the three effective components split according to the efficacy are analyzed, such as: promoting blood circulation and removing blood stasis group (red flower, ephedra), detoxification and expectorant group (Tianzhuhuang, Aristolochia woody, Myrobalan), heat-clearing and detoxification group (Swertia clam, Meconopsis), to carry out the treatment of transplanted liver cancer animal models and anti-tumor immune function Research on the regulation of liver cancer biomarkers; Experimental research on blood stasis model: Observation of the influence of Tibetan medicine on blood viscosity, red blood cell deformability, red blood cell aggregation, white blood cell adhesion, platelet function, and blood coagulation status; The anti-tumor effect of the safflower prescription is excellent. Therefore, through pharmacodynamic research, the scope of the drug’s treatment of diseases will be expanded, and a new research idea and method will be created for the classic Tibetan medicine to prevent and treat early liver cancer lesions, and the prescription will be expanded. The scope of clinical application provides a demonstration for minority medical research

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  • Novel anti-tumor application of seven-ingredient safflower prescription

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Effect test

Embodiment 1

[0036]A seven-flavored safflower prescription medicine, wherein the active ingredients of the seven-flavored safflower prescription medicine are prepared from the following traditional Chinese medicine raw materials in parts by weight: 20 parts by weight of safflower, 17 parts by weight of Tianzhuhuang, 13 parts by weight of Swertia, 22 parts by weight of Myrobalan, 13 parts by weight of Ephedra, 13 parts by weight of Aristolochia aristolochia, and 13 parts by weight of Meconopsis five veins.

[0037] Preparation method: mix safflower, geranium, ephedra, swertia clam, woody aristolochia, meconopsis five veins and myrobalan to obtain a mixture, add 20vt% ethanol solution and 5vt% Acetic acid solution, heating and reflux extraction, the extraction process is divided into two times; the amount of ethanol solution added in the first extraction is 4 times the mass of the mixture, heated to 80 ° C, reflux extraction for 1 hour; the amount of ethanol solution added in the second extra...

Embodiment 2

[0039] A seven-flavored safflower prescription, the active ingredients of which are prepared from the following traditional Chinese medicine raw materials by weight: 24 parts by weight of safflower, 13 parts by weight of Tianzhuhuang, 17 parts by weight of Swertia, 18 parts by weight of Myrobalan, 17 parts by weight of Ephedra, 17 parts by weight of Aristolochia aristolochia, and 17 parts by weight of Meconopsis five veins.

[0040] Preparation method: mix safflower, geranium, ephedra, swertia clam, woody aristolochia, meconopsis five veins and myrobalan to obtain a mixture, add 25vt% ethanol solution and 2vt% Acetic acid solution, heating and reflux extraction, the extraction process is divided into two times; the amount of ethanol solution added in the first extraction is 6 times the mass of the mixture, heated to 60 ° C, reflux extraction for 2 hours; the amount of ethanol solution added in the second extraction It is 3 times the mass of the mixture, heated to 80°C, and ext...

Embodiment 3

[0042] A seven-flavored safflower prescription medicine, wherein the active ingredients of the seven-flavored safflower prescription medicine are prepared from the following traditional Chinese medicine raw materials in parts by weight: 22 parts by weight of safflower, 15 parts by weight of Tianzhuhuang, 15 parts by weight of Swertia, 20 parts by weight of Myrobalan, 15 parts by weight of Ephedra, 15 parts by weight of Aristolochia woody, and 15 parts by weight of Meconopsis five veins.

[0043] Preparation method: mix safflower, geranium, ephedra, swertia clam, woody aristolochia, meconopsis five veins and myrobalan to obtain a mixture, add 23vt% ethanol solution and 3vt% Acetic acid solution, heating and reflux extraction, the extraction process is carried out twice; the addition of ethanol solution in the first extraction is 5 times the mass of the mixture, heated to 70 ° C, reflux extraction for 1.5h; the addition of ethanol solution in the second extraction The amount is ...

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Abstract

The invention provides a novel anti-tumor application of a seven-ingredient safflower prescription. Research is conducted on the anti-liver cancer activity of seven-ingredient safflower pills, mainly the influence on liver cancer cells SMMC-7721 and the influence on the levels of IL-6, ROS and VEGF of an H22 mouse liver cancer model. Induction of apoptosis of liver cancer cells HepG2 of Tibetan medicine amplexicaul swertia bimaculata and meconopsis is explored, a flow cytometry is used for analyzing influences of different medicine concentrations of the Tibetan medicine on cell iron overload and adhesion as well as invasion and athletic ability of the Tibetan medicine, and a pharmacodynamic mechanism of the Tibetan medicine for preventing and treating early liver cancer lesions is determined. Through pharmacodynamic research, the range of the medicine for treating diseases is developed and expanded, a new thought and a new method for research are created for prevention and treatment of early-stage lesions of liver cancer by classic Tibetan medicine prescriptions, the clinical application range of the prescription is expanded, and demonstration is provided for minority medicine research.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a new anti-tumor application of Qiwei safflower prescription medicine. Background technique [0002] Qiwei Honghua Zhusheng Pills, a classic Tibetan medicine prescription, comes from the "Four Medical Classics-Discussion Collection". The whole prescription of Tibetan medicine and the three effective components split according to the efficacy are analyzed, such as: promoting blood circulation and removing blood stasis group (red flower, ephedra), detoxification and expectorant group (Tianzhuhuang, Aristolochia woody, Myrobalan), heat-clearing and detoxification group (Swertia clam, Meconopsis), to carry out the treatment of transplanted liver cancer animal models and anti-tumor immune function Research on the regulation of liver cancer biomarkers; Experimental research on blood stasis model: Observation of the influence of Tibetan medicine on bloo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P35/00
CPCA61K36/17A61K36/185A61K36/264A61K36/286A61K36/51A61K36/66A61K36/899A61P35/00A61K2300/00
Inventor 吴宗耀高增艳朱星昊苗明三徐立军朱守强
Owner 吴宗耀
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