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Application of prismatomeris tetrandra monomer in liver protection

A monomer and yellow root technology, applied in the field of liver disease treatment, can solve the problem of research reports on monomers without yellow root

Pending Publication Date: 2021-06-18
GUANGXI INT ZHUANG MEDICINE HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Nevertheless, there is no research report on the protection of liver and liver by yellow root monomer

Method used

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  • Application of prismatomeris tetrandra monomer in liver protection
  • Application of prismatomeris tetrandra monomer in liver protection

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Experimental program
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Embodiment Construction

[0016] One, the preparation of yellow root monomer

[0017] The yellow root is collected from Fangcheng City, Guangxi Zhuang Autonomous Region, and identified as the dried root of Nanshan flower Prismatomeris tetrandra (Roxb.) K. Schum by Lan Richun, deputy chief pharmacist of Guangxi National Medical Research Institute. The root of 60kg yellow root was extracted 3 times with 95% ethanol backflow, each time for 3 hours, after concentrating, 1200g of extract was obtained, and an appropriate amount of water was added to make it fully dissolved, and the aqueous solution was successively extracted with sherwood oil, ethyl acetate and n-butanol. Concentrate under pressure to obtain 58g of petroleum ether extract, 112g of ethyl acetate extract and 200g of n-butanol extract. 112 g of ethyl acetate extract was subjected to silica gel (200-300 mesh) column chromatography, eluted with petroleum ether-acetone system gradient, and each fraction was collected. Fr.2-3 was separated and pur...

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Abstract

The invention discloses application of a prismatomeria tetrandra monomer in liver protection. The inventor performs high-throughput screening on prismatomeris tetrandra monomeric compounds (HG2, HG3 and HG4) extracted and separated from the ethyl acetate part of prismatomeris tetrandra, the result shows that the number of difference up-regulation genes is 21, and compared with a control group, the Klf15 expression difference has very significant difference. Due to the fact that Klf15 can regulate endogenous and exogenous metabolism of the liver, regulate expression of MMp3 and reduce the liver cell apoptosis level, it can be predicted that a prismatomeria tetrandra monomer can regulate the endogenous and exogenous metabolism of the liver by up-regulating expression of the Klf15 gene, and finally the liver protection effect is achieved. In conclusion, the prismatomeris tetrandra has incalculable potential in research and development of the liver protection medicine, and is worthy of further research and development.

Description

technical field [0001] The invention belongs to the technical field of liver disease treatment, and in particular relates to the application of yellow root monomer in liver protection. Background technique [0002] The yellow root comes from the root of Prismatomeris connata Y.Z.Ruan., a plant of the Rubiaceae family, also known as dog bone wood, Nanshan flower, and triangular petal flower. It is one of the characteristic strong medicinal materials in Guangxi. It can be used for the treatment of rheumatic bone pain, bruises, leukemia, silicosis, anemia, bleeding gums, and urinary tract infection. According to modern literature, the chemical components of yellow root mainly include 1-hydroxyl-2-methylanthraquinone, 2-hydroxyl-3-methoxyanthraquinone, 1,3-dihydroxyl-2-methoxyanthraquinone, 2 -Methylanthraquinone (tecto-quinone), methylisorubiadine (rubiadine), methylisorubidin-1-methyl ether (rubiadine-1-methyl ether), tiger thorn aldehyde (damnacanthal) and B-sitosterol (B-s...

Claims

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Application Information

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IPC IPC(8): A61K31/37A61K31/122A61K36/74A61P1/16A61K125/00
CPCA61K31/37A61K31/122A61K36/74A61P1/16
Inventor 杨增艳
Owner GUANGXI INT ZHUANG MEDICINE HOSPITAL
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