Novel compound extracted from burdock leaves and capable of protecting alcoholic liver injury as well as preparation method and application of novel compound

Abstract

The invention relates to a novel compound extracted from burdock leaves and capable of protecting alcoholic liver injury as well as a preparation method and application of the novel compound, which can effectively solve the problem of preparing the novel compound capable of protecting alcoholic liver injury from burdock leaves and developing the novel application of the medicinal value of burdock leaves. The method comprises the following steps: soaking the burdock leaves in water, filtering, concentrating, sequentially extracting with ethyl acetate, concentrating an ethyl acetate extract under reduced pressure, carrying out silica gel column chromatography, carrying out gradient elution with dichloromethane-methanol, recovering a solvent under reduced pressure, then carrying out MCI column chromatography, carrying out gradient elution with a methanol aqueous solution, combining eluents, drying, and recrystallizing in methanol so as to obtain the novel compound extracted from burdock leaves and capable of protecting alcoholic liver injury. The preparation method is easy to operate, the guidance quality is high, the separation speed is high, the product purity is high, the compound can be effectively used for preparing the medicine for reducing the fat and protecting the alcoholic liver injury, the new application and the medicinal value of the burdock leaves are developed, and the economic and social benefits are huge.

Description

technical field [0001] The invention relates to medicine, especially a new compound extracted from burdock leaves and capable of protecting alcoholic liver damage, its preparation method and application. Background technique [0002] Burdock leaves are the dry basal leaves of the Compositae plant Arctiumlappa. They are widely distributed throughout the country. Among them, Shandong and Xuzhou are the main production areas. They have a long history of medicinal use. Burdock leaves have been recorded in ancient herbal medicines for preventing stroke and hand and foot paralysis. Folks still use burdock leaves to make tea and drink it to prevent hyperlipidemia. [0003] The incidence of alcoholic liver disease is increasing worldwide. It is a disease that develops progressively and will seriously endanger health and even life in the later stage. In addition to alcohol abstinence and symptomatic treatment, there is no effective treatment for alcoholic liver disease in modern med...

AI Technical Summary

Problems solved by technology

[0004] However, the compounds isolated from burdock leaves for regulating blood lipids, preventing and treating alcoholic liver injury, and used to prepare drugs for preventing and treating alcoholic liver injury have not been publicly reported so far.

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