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Multifunctional nanofiber-based composite hemostatic patch and preparation method thereof

A technology of nanofibers and nanofiber membranes, applied in the field of medical supplies, can solve problems such as poor mechanical strength of nanofiber membranes, single function of hemostatic patches, reinfection of wounds, etc., achieve outstanding hemostatic and anti-inflammatory properties, excellent healing effects, and prolonged The effect of changing time

Active Publication Date: 2021-06-04
HENAN YADU IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The skin provides protection for the human body. Once the skin is injured, it will have a great impact on body functions; therefore, after the skin is injured, it is necessary to protect the wound in time to avoid infection of the wound; hemostatic plaster is a commonly used external plaster in daily life It is used for emergency treatment of small wounds, and has the effect of temporarily stopping bleeding and protecting the wound surface; the function of the existing hemostatic plaster is relatively single, most of which are based on protecting the wound, but do not have the effect of eliminating wound inflammation and promoting wound healing;
[0003] The most important component in the hemostatic patch is the liquid-absorbing hemostatic material. The liquid-absorbing layer in the existing hemostatic patch mainly achieves the effect of physical hemostasis through its liquid-absorbing effect. The hemostatic effect is slow, which is not conducive to wound healing, and the liquid-absorbing effect is not good. Ideal, it is easy to cause fluid accumulation around the wound, which will cause re-infection of the wound. At the same time, the hemostatic patch needs to be replaced frequently. A hemostatic material with antibacterial, anti-inflammatory and anti-adhesion properties;
[0004] The nanofiber membrane prepared by electrospinning has a large specific surface area and porosity, and is widely used in the field of medical dressings. However, the wound healing effect of the existing nanofiber membrane dressing is poor, and the mechanical properties of the pure nanofiber membrane poor strength

Method used

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  • Multifunctional nanofiber-based composite hemostatic patch and preparation method thereof
  • Multifunctional nanofiber-based composite hemostatic patch and preparation method thereof
  • Multifunctional nanofiber-based composite hemostatic patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of oxidized dandelion fluff powder: take dandelion fluff and immerse in 3wt% sodium periodate solution for treatment, wash with deionized water, freeze-dry and pulverize to obtain nanoscale oxidized dandelion fluff powder (O-PR);

[0035] Preparation of activated dandelion fluff powder: get dandelion fluff and immerse it in 0.5mol / L sodium bicarbonate solution for treatment, wash with deionized water until the washing liquid is neutral, then freeze-dry and pulverize to obtain nanoscale activated dandelion fluff powder (H- PR);

[0036] Preparation of oxidized dandelion leaf fiber powder: extract dandelion fiber from dandelion leaves, immerse the extracted dandelion leaf fiber in 3wt% sodium periodate solution for treatment, wash with deionized water, freeze-dry and pulverize to obtain nanoscale oxidized dandelion Leaf fiber powder (O-PF);

[0037] Preparation of genipin / ovalbumin solution: disperse the ovalbumin in deionized water and stir evenly under ultr...

Embodiment 2

[0041] Preparation of nanofibrous membranes

[0042] (1) Get the polyvinyl alcohol solution prepared in Example 1, for subsequent use;

[0043] (2) Get the oxidized sodium alginate solution prepared in Example 1 for subsequent use;

[0044] (3) Disperse chitosan (85% degree of deacetylation) in the oxidized sodium alginate solution and stir for reaction, then add polyvinyl alcohol solution to obtain a mixed solution, and add oxidized dandelion fluff powder O-PR ( Prepared in Example 1) after stirring evenly, add silk fibroin to it, and stir evenly to obtain spinning stock solution;

[0045] (4) The spinning stock solution is electrospun to obtain a nanofiber membrane, and the nanofiber membrane is peeled off and soaked in a genipin / ovalbumin solution (the weight ratio of genipin to ovalbumin solution is 0.3:1000). After the joint reaction, the nanofiber membrane is obtained by freeze-drying and sterilizing; the spinning conditions are as follows: the spinning voltage is 16-20k...

Embodiment 3

[0057] Preparation of nanofibrous membranes

[0058] (1) Get the 20wt% polyvinyl alcohol solution prepared in 1250g embodiment 1, for subsequent use;

[0059] (2) get 1875g embodiment 1 preparation 4wt% oxidized sodium alginate solution, standby;

[0060] (3) After dispersing 12.5g chitosan (deacetylation degree 85%) in the oxidized sodium alginate solution and stirring for reaction, the above mixed solution was added into the polyvinyl alcohol solution, and then 7.5g oxidized dandelion fluff powder was added thereto Body O-PR (prepared in Example 1) was stirred evenly to obtain a mixed solution, and 12.5 g of silk fibroin was added to the mixed solution, and the spinning stock solution was obtained after being stirred evenly;

[0061] (4) The spinning stock solution is electrospun to obtain a nanofiber membrane, and the nanofiber membrane is peeled off and soaked in a genipin / ovalbumin solution (the weight ratio of genipin to ovalbumin solution is 0.3:1000). After the joint...

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Abstract

The invention discloses a multifunctional nanofiber-based composite hemostatic patch which is composed of a supporting layer, a dressing layer and a protective layer, and the dressing layer is wrapped between the supporting layer and the protective layer. The dressing layer of the multifunctional hemostatic patch is composed of a nanofiber membrane prepared from polyvinyl alcohol, oxidized sodium alginate, chitosan, silk fibroin, dandelion villus powder, genipin and ovalbumin, and the multifunctional hemostatic patch has the effects of resisting bacteria, preventing adhesion and promoting wound healing; the multifunctional hemostatic patch is long in replacement period, and wound healing time can be effectively shortened.

Description

technical field [0001] The invention belongs to the field of medical supplies, and in particular relates to a multifunctional nanofiber-based composite hemostatic patch and a preparation method thereof. Background technique [0002] The skin provides protection for the human body. Once the skin is injured, it will have a great impact on body functions; therefore, after the skin is injured, it is necessary to protect the wound in time to avoid infection of the wound; hemostatic plaster is a commonly used external plaster in daily life It is used for emergency treatment of small wounds, and has the effect of temporarily stopping bleeding and protecting the wound surface; the function of the existing hemostatic plaster is relatively single, most of which are based on protecting the wound, but do not have the effect of eliminating wound inflammation and promoting wound healing; [0003] The most important component in the hemostatic patch is the liquid-absorbing hemostatic mater...

Claims

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Application Information

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IPC IPC(8): A61F13/02A61L15/24A61L15/28A61L15/32A61L15/40A61L15/42A61L15/44A61L15/46D01D5/00
CPCA61F13/023A61L15/46A61L15/42A61L15/24A61L15/28A61L15/32A61L15/40A61L15/44A61L15/425D01D5/003A61L2300/232A61L2300/404A61L2300/402A61L2300/412A61L2300/30A61L2400/04A61L2300/41A61L2400/12C08L29/04C08L5/04C08L89/00
Inventor 张正男段书霞潘红福闫钧付迎坤常聪周静储旭何孜翰周小婷刘康博林建香郭文远
Owner HENAN YADU IND
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