Benzene occupational exposure and carcinogenic risk assessment method

Abstract

The invention provides a benzene occupational exposure and carcinogenic risk assessment method, which comprises four aspects: a risk understanding module for understanding the theoretical relationship between benzene and carcinogenic risk and understanding the harmfulness of benzene; a risk research module that is used for looking up related data of the relationship between benzene and carcinogenic risk and related experiments, and looking up knowledge of a related benzene exposure mode and exposure quantity; a risk calculation module that is used for replacing the exposed benzene content with the benzene dosage change in the human body and simulating, then simulating and calculating the change relation between the benzene content in the human body and the carcinogenic risk, and finally calculating the carcinogenic risk; and a risk evaluation module that is used for evaluating and analyzing a result of the risk calculation module. Numerical simulation is performed on the benzene dosage in a human body by using a PBPK model and applying ERDEM software; then simulation calculation is carried out on a change relation between the content of benzene in a human body and the carcinogenic risk by using a dose-reaction relation, and finally Monte Carlo simulation is executed by using crystic ball software to simulate the carcinogenic probability.

Description

technical field [0001] The invention belongs to the field of carcinogenic risk assessment methods, in particular to benzene occupational exposure and carcinogenic risk assessment methods. Background technique [0002] Benzene (Benzene, C 6 h 6 ) A hydrocarbon, the simplest aromatic hydrocarbon, is a sweet, flammable, carcinogenic and toxic colorless transparent liquid at room temperature with a strong aromatic odor. It is hardly soluble in water, easily soluble in organic solvents, and can also be used as an organic solvent itself. Benzene is a basic petrochemical raw material, and its output and production technology level are one of the symbols of a country's petrochemical development level. [0003] Benzene was first discovered by Faraday in 1825. At the beginning of the 19th century, Britain, like other European countries, had generally used gas for urban lighting. After the gas is produced from the raw materials used to produce it, there remains an oily liquid that...

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Problems solved by technology

[0004] However, due to the high volatility of benzene, it is easy to spread when exposed to the air

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