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Composition with whitening effect, and preparation method and application thereof, and whitening essence

A composition and whitening technology, applied in the field of daily chemicals, can solve problems such as skin adverse reactions, less application, and increased sensitivity

Pending Publication Date: 2021-05-28
国珍健康科技(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] (1) For internal use products, bifidobacterium fermented products are combined with botanical ingredients such as snow lotus, ginger, wolfberry, rose, etc. for whitening, anti-wrinkle and other efficacy tests, which cannot directly prove that the bifidobacterium fermented products have corresponding skin care functions on the skin ;
[0016] (2) Although the fermentation product of bifidobacterium is acidic, it can soften cutin and promote the exfoliation of dead cutin, but its effectiveness is weaker than that of organic acids such as fruit acid. The effect is more obvious, but the application in whitening is still less;
[0017] (3) The combined use of gluconolactone and lactobionic acid, the exfoliation effect is too strong, which will damage the skin barrier function, increase sensitivity, and even cause serious adverse skin reactions

Method used

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  • Composition with whitening effect, and preparation method and application thereof, and whitening essence
  • Composition with whitening effect, and preparation method and application thereof, and whitening essence
  • Composition with whitening effect, and preparation method and application thereof, and whitening essence

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preparation example Construction

[0059] In the second aspect, the present invention provides a preparation method of a whitening efficacy composition, comprising the following steps: lysing, homogenizing, and solid-liquid separation of the bifidobacterium fermentation broth in sequence, and taking the solution part to obtain the bifidobacteria fermentation lysate product, and then mix the bifidobacterium fermentation lysate, gluconolactone and triethanolamine solution in the formula to prepare the whitening effect composition.

[0060] It should be noted that cell lysis refers to lysing cells so that intracellular substances are released.

[0061] In the present invention, firstly, the bifidobacterium fermentation broth obtained through fermentation is lysed to dissolve the cells, and then homogenized, the cell wall is broken, and the solution part collected after solid-liquid separation is the bifidobacterium fermentation lysate product, and then mix the bifidobacteria fermentation lysate, gluconolactone and...

Embodiment 1

[0086] The preparation of embodiment 1 whitening effect composition

[0087] 1) Activation of strains

[0088] Take the glycerol tube seeds stored in the -60°C refrigerator, inoculate them in a small amount of MRS liquid medium, and culture them statically at 37°C for 30 hours. Spread an appropriate amount of bacteria liquid evenly on the MRS solid medium, and continue to cultivate for 38 hours. After a single colony, store the plate in a refrigerator at 4°C until use.

[0089] 2) Strain fermentation

[0090] Pick a single colony and inoculate it in 20mL MRS liquid medium, culture it statically at 37°C for 30 hours, and when the OD600 reaches 3-4, transfer it to the seeds of the secondary shake flask according to the inoculation amount of 1%, and continue to cultivate it for 24 hours. According to the inoculum amount of 1%, the secondary seed liquid was inoculated in a fermenter (75% liquid content), and cultured statically at 37° C. for 54 hours, and the fermentation was co...

Embodiment 2

[0097] 1) Activation of strains

[0098] Take the glycerol tube seeds stored in the -60°C refrigerator, inoculate them in a small amount of MRS liquid medium, and culture them statically at 37°C for 24 hours. Spread an appropriate amount of bacteria liquid evenly on the MRS solid medium, and continue to cultivate for 6 hours. After a single colony, store the plate in a refrigerator at 4°C until use.

[0099] 2) Strain fermentation

[0100] Pick a single colony and inoculate it in 20mL MRS liquid medium, culture it statically at 37°C for 24 hours, when the OD600 reaches between 3-4, transfer it to the seeds of the secondary shake flask according to the inoculation amount of 1%, and continue to cultivate it for 24 hours. According to the inoculum amount of 1%, the secondary seed liquid was inoculated in a fermenter (75% of the liquid content), and cultured at 37° C. for 48 hours, and the fermentation was completed.

[0101] 3) Fermentation product lysis

[0102] Add 1% lysozy...

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Abstract

The invention provides a composition with a whitening effect, and a preparation method and application thereof and whitening essence, and relates to the technical field of daily chemicals. The composition with the whitening effect comprises the bifidobacterium fermentation lysate, gluconolactone and a triethanolamine solution, the bifidobacterium fermentation lysate and gluconolactone are compounded, the skin barrier function can be improved, the gluconolactone safety can be improved, the effects of brightening skin color, reducing skin surface pigmentation and fading color spots are achieved. The whitening essence provided by the invention is prepared from a composition with a whitening effect, ascorbic acid tetrahexyldecanol, tocopheryl acetate, oil, hydrogenated lecithin and hydrogel. The composition with the whitening effect is matched with the tetra-hexyldecanol ascorbic acid ester, so that the effects of improving oxidation resistance and synergistic whitening are achieved; and a micro-emulsification system is adopted, so that transdermal absorption of effective components in the whitening essence is facilitated. The whitening essence provided by the invention has a good whitening effect and can take effect in a short time.

Description

technical field [0001] The invention relates to the technical field of daily chemicals, in particular to a whitening composition, a preparation method and application thereof, and a whitening essence. Background technique [0002] At present, whitening raw materials are divided according to the mechanism of action, mainly including: tyrosinase activity inhibitors, melanocyte cytotoxic agents, sunscreen agents and chemical peeling agents. [0003] Tyrosinase activity inhibitors mainly achieve a certain whitening effect by inhibiting tyrosinase activity, reducing the production or synthesis of tyrosinase, reducing the transfer of melanin, and accelerating the decomposition of tyrosinase. This type of raw material mainly includes organic acids such as kojic acid, azelaic acid, and aminocyclic acid. This type of whitening raw material should act on the whole process of melanin synthesis and metabolism, and the corresponding products must have good transdermal absorption perform...

Claims

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Application Information

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IPC IPC(8): A61K8/99A61K8/37A61K8/41A61Q19/02A61Q19/08A61Q19/00A61K8/55A61K8/67
CPCA61K8/99A61K8/375A61K8/41A61Q19/02A61Q19/005A61Q19/08A61K8/676A61K8/678A61K8/553A61K2800/85A61K2800/592
Inventor 万洁李永强李爱民李颖邢岩
Owner 国珍健康科技(北京)有限公司
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