Cefoxitin sodium bulk drug

Abstract

The invention discloses a cefoxitin sodium bulk drug. The cefoxitin sodium bulk drug is composed of the following components: cefalotin, a carbamylation reagent, an organic solvent and frosted particles. A production method for the cefoxitin sodium bulk drug comprises the following steps: pouring the cefalotin and the carbamylation reagent into a reaction vessel for reaction to generate an intermediate product (6R,7S)-3-carbamoyloxymethyl-7-[2-(2-thienyl)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-formic acid, and uniformly stirring a mixed solution of the cefalotin and the carbamoylation reagent for 5 minutes by using stirring equipment; and subjecting the intermediate product (6R,7S)-3-carbamoyloxymethyl-7-[2-(2-thienyl)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-formic acid to a reaction with a methanol-lithium methoxide solution at a temperature of -70 DEG C to 10 DEG C, and introducing an oxymethyl group to the site 7 so as to generate cefoxitin acid. According to the cefoxitin sodium bulk drug, a mixed cellulose ester microfiltration membrane is adopted for suction filtration, so suction filtration effect is improved, and a medicine processing process is promoted.

Description

technical field [0001] The invention relates to the technical field of cefoxitin sodium crude drug, in particular to the cefoxitin sodium crude drug. Background technique [0002] Cefoxitin sodium, with a chemical formula of C16H16N3NaO7S2 and a molecular weight of 449.43[1], is a cefoxitin antibiotic. The core is similar to cephalosporins and has similar antibacterial properties, so it is also customarily included in the second-generation cephalosporins. [0003] The existing powdered cefoxitin sodium bulk medicine has insufficient ingredients, resulting in insufficient dissolution during use, thereby affecting the use effect, and the suction filtration effect is not good, which affects the production process. Contents of the invention [0004] The purpose of the present invention is to provide cefoxitin sodium crude drug, to solve the existing cefoxitin sodium crude drug powder grinding not enough composition that proposes in the above-mentioned background technology, c...

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Problems solved by technology

[0004] The purpose of the present invention is to provide cefoxitin sodium crude drug, to solve the existing cefoxitin sodium crude drug powder grinding not enough composition that proposes in the above-mentioned background technology, cause when dissolving insufficiently during use, thereby influenced use effect, and The effect of suction filtration is not good, which affects the production process