New application of niclosamide

A technology of niclosamide and herbicide, applied in the new application field of medicine, can solve the problems of low success rate of clinical rescue, lack of antidote, etc., and achieve the effect of low toxicity and less damage

Pending Publication Date: 2021-05-04
UNIVERSITY OF MACAU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the lack of effective antidotes, the success rate of clinical rescue of PQ poisoning, especially in the case of suicide ingestion, is very low, and effective therapeutic drugs are urgently needed

Method used

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  • New application of niclosamide
  • New application of niclosamide
  • New application of niclosamide

Examples

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Embodiment Construction

[0024] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all conventional products that could be purchased from the market.

[0025] Currently, there is no effective treatment for bipyridine herbicide poisoning, especially paraquat poisoning.

[0026] Niclosamide (NLS) (CAS No.: 50-65-7), also known as spirulina, snailicide, spirulina, etc., is a salicylamide derivative. NLS is widely used in killing eels, killing mollusks, and preventing and controlling tapeworms in livestock such as cattle, sheep, pigs and poultry. In humans, niclosamide ...

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Abstract

The invention relates to the technical field of new application of medicines, and discloses new application of niclosamide. The invention specifically discloses application of niclosamide in preparation of a medicine for treating bipyridine herbicide, especially paraquat poisoning, application in preparation of a medicine for treating organ injury caused by poisoning, and a herbicide comprising paraquat and niclosamide.

Description

technical field [0001] The invention relates to the technical field of new application of medicines, in particular to the new application of niclosamide. Background technique [0002] Paraquat (Paraquat, PQ) is one of the most famous bipyridine herbicides, also known as Grass Shark, Paraquat, Paraquat, Gramoxone, etc. It is a fast-killing herbicide. PQ has been used in more than 100 countries around the world because of its excellent characteristics such as wide weeding spectrum, high efficiency and low cost, no pollution to the environment, flexible application, and safe use. PQ has reduced production costs, increased crop yields, liberated rural labor, and made a great contribution to the increase in world grain production, and its indirect economic benefits are immeasurable. However, cases of poisoning and even death caused by accidental ingestion, especially suicide active ingestion, have occurred from time to time. It is estimated that before the ban, more than ten th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/167A61P1/16A61P11/00A01N43/40A01N37/40A01P13/00
CPCA61K31/167A61P1/16A61P11/00A01N43/40A01N37/40
Inventor 陈修平赵文文
Owner UNIVERSITY OF MACAU
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