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Application of methylene blue to treatment of early acute paraquat poisoning

A paraquat acute and methylene blue technology, applied in the field of emergency medicine, can solve the problem of high fatality rate

Inactive Publication Date: 2015-01-07
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is highly toxic to humans and animals, and there is no specific drug for treatment after acute poisoning, and the fatality rate is extremely high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0018] After discovering that the patient has taken paraquat by mistake or intentionally orally, use methylene blue 2 mg / kg within 0 to 1 hour.

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PUM

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Abstract

The invention belongs to the field of emergency medicine and particularly relates to an application of methylene blue to the treatment of early acute paraquat poisoning. The methylene blue is used for treating a pulmonary fibrosis disease caused by the paraquat poisoning. When the methylene blue is adopted for the early intervening treatment of a paraquat poisoning patient, the lung tissue superoxide dismutase (SOD) activity of the paraquat poisoning patient can be obviously increased, and the malonaldehyde (MDA) content and the lactic dehydrogenase (LDH) activity can be reduced, so that the pathological damage of lung tissues after paraquat poisoning is reduced, the occurrence and the development of paraquat poisoning pulmonary fibrosis are restrained, and the mortality of the paraquat poisoning patient is reduced, therefore, the patient prognosis is improved.

Description

technical field [0001] The invention discloses the application of methylene blue in the treatment of early paraquat acute poisoning, which belongs to the field of emergency medicine. Background technique [0002] Paraquat is an organic heterocyclic fast-acting contact defoliating herbicide commonly used in the world. It is highly toxic to humans and animals, and there is no specific drug for treatment after acute poisoning, and the fatality rate is extremely high. At present, the treatment of paraquat poisoning is still mainly to reduce absorption or promote excretion. Therefore, it has become the focus of emergency medicine to find an effective drug with high efficiency and low toxicity for the treatment of acute paraquat poisoning in the early stage. [0003] Methylene blue (MB) is a reducing agent, easily soluble in water, easy to pass through the cell membrane, relatively non-toxic and side effects, and is an approved clinical drug. Methylene blue has been used extensi...

Claims

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Application Information

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IPC IPC(8): A61K31/5415A61P11/00A61P39/02
CPCA61K31/5415
Inventor 范红斌庞庆丰杜斌陈俊良
Owner JIANGNAN UNIV
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