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Anti-tumor composition, application thereof and anti-tumor medicine comprising anti-tumor composition

A composition and anti-tumor technology, applied in the field of biomedicine, can solve problems such as increasing radiotherapy, and achieve the effects of increasing sensitivity, enhancing therapeutic effect, and increasing immune activation

Inactive Publication Date: 2021-04-23
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this context, people have tried to increase the abspic effect of radiotherapy by combining immune checkpoint inhibitors, however, in clinical practice, less than 30% of patients showed abstemotic effects after receiving radiotherapy and immune checkpoint inhibitors simultaneously. isolation effect

Method used

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  • Anti-tumor composition, application thereof and anti-tumor medicine comprising anti-tumor composition
  • Anti-tumor composition, application thereof and anti-tumor medicine comprising anti-tumor composition
  • Anti-tumor composition, application thereof and anti-tumor medicine comprising anti-tumor composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Example 1 Radiosensitization of CDDP and CDDP-NPs

[0086] The mouse lung adenocarcinoma cell line LLC (Lewis lung cancer) cells were inoculated subcutaneously in the abdomen of C57BL / 6 mice, when the volume of the subcutaneous tumor grew to about 55mm 3 At the same time, the mice were randomly divided into 6 groups: PBS, CDDP (3mg / kg), CDDP-NPs (10mg / kg), RT, RT+CDDP, RT+CDDP-NPs, 5 mice in the RT+CDDP-NPs group mice, and 6 mice in each of the other five groups. The doses of CDDP-NPs were calculated on the basis of equivalent CDDP. CDDP and CDDP-NPs were administered through the tail vein. Radiation other than RT. The treatment started on day 0: PBS group was given 200 μl PBS tail vein injection on day 0, once in total; CDDP, CDDP-NPs, RT+CDDP and RT+CDDP-NPs groups were given CDDP or CDDP-NPs once; RT, RT+CDDP and RT+CDDP-NPs groups were given 5 consecutive radiation treatments from day 1 to day 5, 2Gy each time. The experiment was terminated on day 13 for a tota...

Embodiment 2

[0090] Example 2 Blood routine test results of mice in each group on day 3 and day 10 after CDDP, CDDP-NPs combined with radiotherapy

[0091] The subcutaneous LLC tumor model, grouping of tumor-bearing mice, and treatment methods were the same as in Example 1. And selected healthy mice without tumors as the control group (Health control), on the 3rd and 10th days of treatment, the peripheral blood of each group of mice was collected for blood routine testing, and the white blood cell count (WBC) in the peripheral blood was measured. Red blood cell count (RBC), hemoglobin concentration (HGB), hematocrit (HCV), experimental results such as figure 2 . On the third day of treatment, although all mice receiving radiotherapy showed a certain degree of WBC reduction compared with the PBS group, the levels of WBC, RBC, HGB and HCT were between RT+CDDP and RT+CDDP-NPs. There was no difference between groups of mice. The results of detection on the 10th day of treatment showed that...

Embodiment 3

[0092] Example 3 Biochemical detection results of peripheral blood of mice in each group on the 3rd day and 10th day after CDDP, CDDP-NPs combined with radiotherapy

[0093] Healthy mice, subcutaneous LLC tumor models, and tumor-bearing mice were divided into groups and treated in the same way as in Example 2. On the third and tenth days of treatment, the peripheral blood serum of each group of mice was collected for biochemical detection, and the biochemical indicators in the serum were measured. Glutamate-pyruvate aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and creatinine (CREA) levels. Experimental results such as image 3 As shown, on the 3rd day and the 10th day of treatment, there was no significant difference in each index between mice in each group.

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Abstract

The invention relates to the technical field of biological medicines, in particular to an anti-tumor composition, an application thereof and an anti-tumor medicine comprising the anti-tumor composition. The anti-tumor composition comprises a cis-platinum nano preparation and an immune checkpoint inhibitor. According to the anti-tumor composition provided by the invention, the cis-platinum nano preparation and the immune checkpoint inhibitor are combined for application, so that the sensitivity of malignant tumors to radiotherapy can be obviously improved, the telecentric effect of radiotherapy of malignant tumors in middle and advanced stages is effectively improved, and a systematic inhibition effect on metastatic tumors is achieved through the telecentric effect of local radiotherapy. Synergistic radiotherapy can effectively enhance the treatment effect on multiple metastatic lesions of the whole body of a patient suffering from middle and advanced stage cancer.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an antitumor composition, its application and antitumor drugs. Background technique [0002] Cancer refers to the local mass formed by the abnormal proliferation of local cells under the action of various carcinogenic factors. The uncontrolled cell growth and the disorder of the cell cycle are the common characteristics of all cancers. At present, cancer is one of the major public health problems that seriously threaten the health of the population in our country. According to the latest statistics, cancer deaths account for 23.91% of all deaths among residents, and the incidence and death of cancer have continued to rise in the past ten years. The medical expenditure caused by cancer exceeds 220 billion, and the prevention and control situation is severe. [0003] Lack of effective control of metastatic tumors is the main cause of death for cancer patients. Taking lung canc...

Claims

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Application Information

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IPC IPC(8): A61K33/243A61K45/06A61K47/59A61P35/00A61P35/04
CPCA61K33/243A61K45/06A61K47/59A61P35/00A61P35/04
Inventor 汤朝晖王莹沈娜刘林林陈学思
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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