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Preparation method of vitamin-B buccal tablets and chewable tablets

A technology of B vitamins and chewable tablets, which is applied in the direction of food science, can solve the problems of large amount of sweeteners, heavy bitterness, and low content of B vitamins, and achieve the effect of improving the taste

Pending Publication Date: 2021-04-20
石药集团中诺药业(泰州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] B vitamins include 8 vitamins including vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacinamide, pantothenic acid, folic acid and biotin. B vitamins can produce many beneficial effects: first, promote the three major products of sugar, fat and protein Second, it can produce the nutrients needed for hematopoiesis, help digestion and absorption, promote the detoxification ability of the liver, relieve the pressure of the body, make people energetic, relieve fatigue, and play a role The effect of hangover and detoxification, thirdly, it can maintain the normal work of the nervous system and the nutrients needed for health, can effectively prevent atherosclerosis, reduce the generation of coronary atherosclerotic plaque, and can also enhance fat and Cholesterol metabolism; among them, vitamin B2 and nicotinamide raw materials have relatively bitter taste and poor taste. The oral products of B vitamins on the market are mainly swallowed tablets. Non-sugar-free products with relatively good taste and low B vitamin content; products with high B vitamin content have poor taste and use a lot of sweeteners

Method used

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  • Preparation method of vitamin-B buccal tablets and chewable tablets
  • Preparation method of vitamin-B buccal tablets and chewable tablets

Examples

Experimental program
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Effect test

example 1

[0047]The content of each component per 1000 tablets is: thiamine hydrochloride 2g, riboflavin 2g, pyridoxine hydrochloride 2g, vitamin B12 (1%) 0.2g, nicotinamide 50g, folic acid 0.4g, biotin (1%) ) 8g, D-calcium pantothenate 17g, sorbitol 658.4g, anhydrous citric acid 24g, magnesium stearate 16g, hypromellose 10g, aspartame 2g, yellow peach essence 8g;

[0048] Step 1: Preparation of Niacinamide Sustained Release Granules

[0049] 1) Weigh 100g of niacinamide, 354g of sorbitol, 24g of anhydrous citric acid, 20g of hypromellose, and 2g of aspartame after passing through an 80-mesh sieve, and place them in a wet mixing granulator with stirring speed Set it to 600rpm, set the chopping speed to 1200rpm, mix for 5 minutes, then add 70% ethanol as a wetting agent, the amount added can completely wet the mixture, set the stirring speed to 600rpm, set the chopping speed to 1200rpm, and granulate Set the time to 100S, then set the drying temperature of the blast drying oven to 40°C,...

example 2

[0061] The content of each component per 1000 tablets is: thiamine hydrochloride 8g, riboflavin 7g, pyridoxine hydrochloride 8g, vitamin B12 (1%) 0.2g, nicotinamide 36g, folic acid 0.4g, biotin (1%) ) 8g, D-calcium pantothenate 14g, sorbitol 883.5g, magnesium stearate 20g, hypromellose 5.4g, aspartame 1.5g, corn essence 8g;

[0062] Step 1: Preparation of Niacinamide Sustained Release Granules

[0063] 1) Dissolve 1g of aspartame in 10g of 70% ethanol solution to prepare aspartame 70% ethanol solution for later use.

[0064] 2) Weigh 72g of niacinamide, 176.2g of sorbitol, and 10.8g of hypromellose after passing through an 80-mesh sieve, and place them in a wet mixing granulator, set the stirring speed to 600rpm, and the chopping speed to 1200rpm, mix The time is 5 minutes, add aspartame 70% ethanol solution, the stirring speed is set to 600rpm, the chopping speed is 1200rpm, the granulation time is 100S, and then dried in a blast drying oven at 40°C until the moisture conten...

example 3

[0076] The content of each component per 1000 tablets is: 7g of thiamine hydrochloride, 7g of riboflavin, 7g of pyridoxine hydrochloride, 0.2g of vitamin B12 (1%), 40g of nicotinamide, 0.4g of folic acid, biotin (1%) ) 4g, D-calcium pantothenate 12g, sorbitol 1086.9g, magnesium stearate 24g, hypromellose 2g, aspartame 1.5g, wheat flavor 8g.

[0077] Step 1: Preparation of Niacinamide Sustained Release Granules

[0078] 1) Dissolve 4g of hypromellose in 40g of 85% ethanol solution to prepare hypromellose 85% ethanol solution for later use;

[0079] 2) Weigh 80g of niacinamide and 316g of sorbitol after passing through an 80-mesh sieve, and place them in the wet mixing granulator in turn, set the stirring speed at 600rpm, the chopping speed at 1200rpm, and the mixing time for 5min, then add hydroxypropyl Methyl cellulose 85% ethanol solution, the stirring speed is set to 600rpm, the chopping speed is 1200rpm, the granulation time is 100S, and then dried in a blast drying oven a...

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Abstract

The invention discloses a preparation method of vitamin-B buccal tablets and chewable tablets, and belongs to the technical field of health foods. The preparation method of the vitamin-B buccal tablets and chewable tablets comprises the following steps of preparing vitamin B and auxiliary materials. According to the vitamin-B buccal tablets or chewable tablets, a food processing taste masking technology and a pharmaceutical preparation slow release technology are organically combined and applied, and the prepared vitamin-B buccal tablets or chewable tablets have the characteristic of sugar-free slow release, can be rich in a large amount of vitamin-B, particularly can be rich in nicotinamide with relatively heavy bitterness, and can well mask the bitterness of the nicotinamide; and therefore, the taste of the vitamin-B buccal tablets and chewable tablets is effectively improved, and the absorption effect of the product is not influenced.

Description

technical field [0001] The invention belongs to the technical field of health food, in particular to a method for preparing B vitamin buccal tablets and chewable tablets. Background technique [0002] B vitamins include 8 vitamins including vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacinamide, pantothenic acid, folic acid and biotin. B vitamins can produce many beneficial effects: first, promote the three major products of sugar, fat and protein Second, it can produce the nutrients needed for hematopoiesis, help digestion and absorption, promote the detoxification ability of the liver, relieve the pressure of the body, make people energetic, relieve fatigue, and play a role The effect of hangover and detoxification, thirdly, it can maintain the normal work of the nervous system and the nutrients needed for health, can effectively prevent atherosclerosis, reduce the generation of coronary atherosclerotic plaque, and can also enhance fat and Cholesterol metabolism; am...

Claims

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Application Information

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IPC IPC(8): A23L33/15A23L33/125A23L33/10A23L5/20
Inventor 武运浦张瑞国吴慧星许乐
Owner 石药集团中诺药业(泰州)有限公司
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