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Application of pedf-derived short peptides in the treatment of osteoarthritis

A short peptide, factor-derived technology for tendon healing to address issues such as limited treatment options

Pending Publication Date: 2021-04-16
BRIM BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Treatment options for OA are very limited

Method used

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  • Application of pedf-derived short peptides in the treatment of osteoarthritis
  • Application of pedf-derived short peptides in the treatment of osteoarthritis
  • Application of pedf-derived short peptides in the treatment of osteoarthritis

Examples

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Embodiment Construction

[0016] Embodiments of the present invention relate to methods for preventing and / or treating osteoarthritis using PEDF-derived short peptides (PDSP). The present invention is based on the surprising discovery that certain short peptides derived from pigment epithelium-derived factor (PEDF) can reduce pain in osteoarthritis and confer articular cartilage repair by inducing differentiation of mesenchymal cells to form chondrocytes.

[0017] Osteoarthritis is a degenerative disorder caused by the breakdown of articular cartilage (AC) in synovial joints. However, the ability of AC to self-heal is limited due to the lack of blood vessels and quiescence of articular chondrocytes. Normal mature cartilage consists of chondrocytes that differentiate from mesenchymal cells during embryonic development. Differentiated chondrocytes, the only cell type found in normal mature cartilage, synthesize sufficient amounts of cartilage-specific extracellular matrix (ECM) to maintain matrix integr...

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Abstract

A method for treating and / or preventing osteoarthritis includes administering to a subject in need thereof a pharmaceutical composition comprising a PEDF-derived short peptide (PDSP) or a variant of the PDSP, wherein the PDSP comprises residues 93-106 of human pigmented epithelium-derived factor (PEDF), and wherein the variant of the PDSP contains serine-93, alanine-96, glutamine-98, isoleucine-103, isoleucine-104, and arginine 106 of the PDSP and contains one or more amino acid substitutions at other positions, wherein residue location numbers are based on those in the human PEDF.

Description

technical field [0001] The present invention relates to PEDF-derived peptides and their use in tendon healing after injury. Background technique [0002] Osteoarthritis (OA), the most common type of joint disease, is a degenerative disorder caused by the breakdown of articular cartilage in synovial joints. With age, articular cartilage degenerates at the cellular level (eg, chondrocytes). There is a reduced number of chondrocytes and proteoglycans, resulting in an overall reduction in cartilage thickness. Disruption of the structure and function of articular chondrocytes (ACs) leads to osteoarthritis, which affects millions of people worldwide. However, due to the lack of blood vessels and quiescence of articular chondrocytes, the ability of AC to self-heal in larger traumas is limited (Khan et al., 2008, Cartilage integration: An assessment of the causes of integration failure during cartilage repair "Cartilage integration: evaluation of the reasons for failure of integr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K38/19A61K38/00A61K38/10A61K38/16A61K38/17
CPCA61K9/0019A61P19/02A61K38/10A61K38/00C07K7/08C07K14/475
Inventor 李文机李元铭曹友平何宗权
Owner BRIM BIOTECH INC
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