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Wound flushing fluid as well as preparation method and application thereof

A technology for washing liquid and wounds, which is applied in the field of medicine, which can solve the problems of insufficient sterilization ability of normal saline, and achieve the effects of improving the ability of removing bacteria, reducing the incidence of wound infection, and improving permeability

Pending Publication Date: 2021-04-16
上海盈舜医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For this reason, the present invention provides a kind of wound flushing liquid, to solve the problem that the sterilization ability of physiological saline is insufficient in the prior art

Method used

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  • Wound flushing fluid as well as preparation method and application thereof
  • Wound flushing fluid as well as preparation method and application thereof
  • Wound flushing fluid as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The present embodiment provides a kind of wound washing solution, which contains 1 g of EDTA, 1 g of hydrogen peroxide, 0.5 g of iodophor, 2 g of disodium hydrogen phosphate, 2 g of potassium dihydrogen phosphate in every 1 liter of said wound washing liquid, and the concentration 100mmol / L hypertonic saline. The pH value of the wound washing fluid is 7.4, and the wound washing fluid is sterilized. Among them, disodium hydrogen phosphate and potassium dihydrogen phosphate solvent can better control the pH value of the flushing solution, and at the same time make the flushing solution have better permeability. Hypertonic saline with EDTA added as wound irrigation can improve the ability to remove bacteria and reduce the incidence of wound infection; EDTA is widely used in clinical treatment and has good safety for the human body; EDTA is cheap and easy to promote and use; At the same time, the addition of hydrogen peroxide further improved the bactericidal efficiency of...

Embodiment 2

[0026] The present embodiment provides a kind of preparation method of wound washing fluid, comprises the following steps:

[0027] Step 1, dissolving 1.5-8 g of disodium hydrogen phosphate and 0.5-10 g of potassium dihydrogen phosphate crystalline powder in water, adding an appropriate amount of medicinal activated carbon, stirring and adsorbing, and decarbonizing to obtain a mixed solution;

[0028] Step 2, adding the mixed solution in step 1 into hypertonic saline with a concentration of 95-100mmol / L, adjusting the pH and osmotic pressure to an appropriate value; the pH value is 7.4.

[0029] Step 3, adding 0.5-10g of EDTA, 1-4g of hydrogen peroxide and 0.5-2g of iodophor to the mixed solution obtained in step 2, and performing sterilization treatment to obtain the wound washing solution.

Embodiment 3

[0031] Efficacy and Toxicity Tests

[0032] Materials and methods

[0033] The wound washing solution refers to EDTA-NS solution (pH adjusted to 7.4) with EDTA concentration of 1 mmol / L obtained by dissolving EDTA in hypertonic saline. Physiological saline and soap solution served as control groups. Both the EDTA-NS solution and the control solution were autoclaved.

[0034] This study included in vitro toxicity experiments and various animal models to evaluate the efficacy of EDTA-NS. The in vitro toxicity test used the cell viability test (annexin V / PI staining) to compare EDTA-NS and

[0035] saline. Then we used rats to establish animal models of different wounds (with or without bone exposure), and contaminated or infected the wounds with Staphylococcus aureus or Escherichia coli, and then studied the curative effect of EDTA-NS irrigation.

[0036] Cell Viability Analysis

[0037] Fibroblasts and endothelial cells are widely used in vitro to test the toxicity of irr...

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Abstract

The invention belongs to the field of medicine, and discloses a wound flushing fluid. 1L of the wound flushing fluid comprises 0.5-10 g of EDTA, 1-4 g of hydrogen peroxide, 0.5-2 g of iodophor, 1.5-8 g of disodium hydrogen phosphate, 0.5-10 g of potassium dihydrogen phosphate and hypertonic saline water, wherein the concentration of the hypertonic saline water is 95-100 mmol / L, the PH value of the wound flushing fluid is 7.4, and the wound flushing fluid is sterilized. According to the invention, the high-permeability saline water added with EDTA (Ethylene Diamine Tetraacetic Acid) is used as the wound flushing fluid, so that the bacterium removal capability can be improved, and the wound infection occurrence rate is reduced; therefore, the problem of insufficient degerming capacity of normal saline in the prior art is solved; besides, the EDTA is widely applied to clinical treatment and has good safety to human bodies, is low in price and convenient to popularize and use.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a wound washing liquid and its preparation method and application. Background technique [0002] Treatment of open fractures requires thorough irrigation and debridement to prevent infection and promote healing. Adding surfactants, bactericides, etc. to the rinsing solution can improve the ability of the rinsing solution to remove bacteria. However, some studies have shown that, compared with normal saline, after adding the above substances, the ability to remove bacteria is improved, but the increase The biological toxicity of the washing solution. Therefore, recent studies recommend the use of saline without any added substances for irrigating, on the grounds that these substances increase the toxicity of the irrigating fluid and affect the therapeutic effect. Overall, in the treatment of open fractures, normal saline is still the preferred irrigation solution for most surge...

Claims

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Application Information

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IPC IPC(8): A61K33/40A61K9/08A61K47/02A61P17/02A61P31/02A61P31/04A61K31/198A61K31/79A61K33/14
Inventor 郑宪友朱弘一孙建
Owner 上海盈舜医疗科技有限公司
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