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Preparation method of high-purity polyguluronic acid

A polyguluronic acid, high-purity technology, applied in the field of preparation of polyguluronic acid, can solve the problems of high cost, long purification time, low yield, etc., achieve high product utilization and purity, prevent The effect of low purity and low degree of polymerization

Inactive Publication Date: 2021-04-13
青岛海之林生物科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Prior art mainly adopts hydrochloric acid degradation method, separates by the difference of guluronic acid and mannuronic acid soluble pH, causes mannuronic acid waste, can't utilize, and this technology passes isomerase (can make mannuronic acid Acid is converted into guluronic acid) and converted into guluronic acid of a single structure for full utilization, and finally through vacuum hot-melt polycondensation method, dehydration condensation forms a polymer with high purity, and gets rid of the conventional use of anion exchange chromatography. The operation of this method is complicated, the cost is high, and the purification time is long. Purification by anion chromatography is complicated in operation and low in yield, and a part of mannuronic acid is not utilized. Therefore, we provide a high-purity polygulose The preparation method of aldehyde acid

Method used

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Embodiment 1

[0020] The invention provides a technical solution: a high-purity polyguluronic acid, the formula of the polyguluronic acid is: 40-55 parts of raw materials, 16-34 parts of auxiliary agents, more specific raw materials 46 parts, 28 parts of additives, raw materials include: alginate 34, concentrated hydrochloric acid 22, sodium bicarbonate 14, additives include: phase isomerase 16, food acid 8, polyol 6, alcohol 20, acrylamide 5, Heavy water 6, methyl aminomethane 3, edible acids include citric acid, malic acid, fumaric acid and adipic acid; epimerases include phosphoglycerate epimerase and glucose phosphate epimerase.

[0021] A preparation method of high-purity polyguluronic acid, comprising the following steps:

[0022] Step 1: Using alginate as raw material, prepare a colloidal solution with a certain concentration, slowly add a certain amount of concentrated hydrochloric acid, react the solution at 90°C for 10 hours, and centrifuge to collect the precipitate;

[0023] St...

Embodiment 2

[0028] The invention provides a technical solution: a high-purity polyguluronic acid, the formula of the polyguluronic acid is: 40-55 parts of raw materials, 16-34 parts of auxiliary agents, more specific raw materials 46 parts, 28 parts of additives, raw materials include: alginate 40, concentrated hydrochloric acid 18, sodium bicarbonate 12, additives include: phase isomerase 18, edible acid 8, polyol 7, alcohol 18, acrylamide 5, Heavy water 6, methyl aminomethane 4, edible acids include citric acid, malic acid, fumaric acid and adipic acid; epimerases include phosphoglycerate epimerase and glucose phosphate epimerase.

[0029] A preparation method of high-purity polyguluronic acid, comprising the following steps:

[0030] Step 1: Using alginate as raw material, prepare a colloidal solution with a certain concentration, slowly add a certain amount of concentrated hydrochloric acid, react the solution at 90°C for 10 hours, and centrifuge to collect the precipitate;

[0031] ...

Embodiment 3

[0036] The invention provides a technical solution: a high-purity polyguluronic acid, the formula of the polyguluronic acid is: 40-55 parts of raw materials, 16-34 parts of auxiliary agents, more specific raw materials 46 parts, 28 parts of additives, raw materials include: alginate 45, concentrated hydrochloric acid 16, sodium bicarbonate 11, additives include: phase isomerase 21, food acid 8, polyol 7, alcohol 15, acrylamide 5, Heavy water 6, methyl aminomethane 3, edible acids include citric acid, malic acid, fumaric acid and adipic acid; epimerases include phosphoglycerate epimerase and glucose phosphate epimerase.

[0037] A preparation method of high-purity polyguluronic acid, comprising the following steps:

[0038] Step 1: Using alginate as raw material, prepare a colloidal solution with a certain concentration, slowly add a certain amount of concentrated hydrochloric acid, react the solution at 90°C for 10 hours, and centrifuge to collect the precipitate;

[0039] St...

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Abstract

The invention relates to the technical field of polyguluronic acid, in particular to high-purity polyguluronic acid which comprises the following raw materials in parts by weight: 40-55 parts of raw materials, and 16-34 parts of auxiliaries, more specificcally, 46 parts of raw materials and 28 parts of auxiliaries, and the raw materials include: 28-50 parts of algin, 10-25 parts of concentrated hydrochloric acid and 6-18 parts of sodium bicarbonate. The invention further discloses a preparation method of the high-purity polyguluronic acid, mannuronic acid can be converted into guluronic acid through isomerase, the guluronic acid is converted into guluronic acid of a single structure to be completely utilized, the product utilization rate and purity are high, it is guaranteed that the mannuronic acid is completely converted into the guluronic acid, the problem that the purity is not high in the later polymerization process is solved, the polymerization degree of polyguluronic acid purified through anion chromatography is low, operation is complex, and polyguluronic acid with the high polymerization degree can be obtained through a vacuum hot melt polycondensation method.

Description

technical field [0001] The invention relates to the technical field of polyguluronic acid, in particular to a preparation method of high-purity polyguluronic acid. Background technique [0002] Prior art mainly adopts hydrochloric acid degradation method, separates by the difference of guluronic acid and mannuronic acid soluble pH, causes mannuronic acid waste, can't utilize, and this technology passes isomerase (can make mannuronic acid Acid is converted into guluronic acid) and converted into guluronic acid of a single structure for full utilization, and finally through vacuum hot-melt polycondensation method, dehydration condensation forms a polymer with high purity, and gets rid of the conventional use of anion exchange chromatography. The operation of this method is complicated, the cost is high, and the purification time is long. Purification by anion chromatography is complicated in operation and low in yield, and a part of mannuronic acid is not utilized. Therefore, ...

Claims

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Application Information

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IPC IPC(8): C08B37/04C12P19/24C12P19/02
CPCC08B37/0003C08B37/0084C12P19/24C12P19/02
Inventor 刘兴勇赵静刘晶营付德珍孙彤胡海月李晓慧
Owner 青岛海之林生物科技开发有限公司
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