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Traditional Chinese medicine ointment formula for treating chloasma and preparation method and application thereof

A technology for traditional Chinese medicines and APIs, applied in the field of medicine, can solve the problems of inability to form a unified syndrome differentiation and treatment system, difficult to master standards, and extremely high requirements for personal experience in acupuncture.

Active Publication Date: 2021-04-09
LIAONING HUANREN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

External treatment methods are difficult to cure the root cause, and are often prone to relapse; acupuncture requires extremely high personal experience and is difficult to promote; in terms of internal treatment, most doctors only rely on personal experience for syndrome differentiation and treatment, and there are a large number of folk prescriptions, so it is impossible to form a unified Syndrome differentiation and treatment system, and the standard is difficult to grasp, and it is difficult to improve the cure rate

Method used

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  • Traditional Chinese medicine ointment formula for treating chloasma and preparation method and application thereof
  • Traditional Chinese medicine ointment formula for treating chloasma and preparation method and application thereof
  • Traditional Chinese medicine ointment formula for treating chloasma and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Example 1 Preparation method of traditional Chinese medicine formula granule ointment

[0102] Prescription dispensing: use traditional Chinese medicine formula granule dispensing equipment to carry out prescription dispensing and preparation according to the prescription quantity.

[0103] Redissolving: Add water 1.3 times the total weight of the granules into the pot of the cream square machine, set the temperature of the heat preservation and paste boiling to 55°C, set the time to 10 minutes, start heating and stirring, when the temperature reaches above 50°C, slowly Slowly add the adjusted Chinese medicine formula granules.

[0104] Boil ointment: After the granules are completely dissolved, set the heat preservation temperature and ointment boiling temperature to 80°C, and set the time (34 minutes / 500g granules), so that the medicinal solution will gradually become a thick clear ointment. (At this time, the refractive index should be measured by Abbe refractomete...

experiment example 1

[0138] Take the traditional Chinese medicine formula granule ointment prepared in Example 1 to carry out pharmacodynamic experiment research.

[0139] 1. Materials and reagents

[0140] 1.1 Materials and Instruments

[0141] Experimental animals: 50 Kunming female mice, SPF grade, weighing 30±2g, placed in the observation room for observation (room temperature 25±1°C, relative temperature 50-60%), natural light, day and night light and dark alternation time 12h, Free to eat and drink, well ventilated and clean. After 7 days, they were randomly divided into normal control group, model control group, low-dose group, middle-dose group and high-dose group, with 10 rats in each group.

[0142] Main instruments: electronic analytical balance (USA DENVER company), optical microscope digital camera system (Japan OLYMPUS), ACS-3H-B electronic scale (Zhongshan Jinli Electronic Scale Co., Ltd.), LG10-2.4 centrifuge (Beijing Medical Instrument Repair factory), three-purpose electric he...

Embodiment 2

[0176] The difference with Example 1 is that, compared with the prescription of Example 1, the prescription of Example 2 does not contain the six traditional Chinese medicines of Angelica sinensis, Chuanxiong, Peach kernel, safflower, motherwort, and turmeric.

[0177] 1. Prescription

[0178]

[0179]

[0180] 2. Preparation method

[0181] Take a total of 525.5g of formula granules according to the prescription, add 683.15g of warm water at 55°C, stir well to completely redissolve the granules, heat and boil the paste at 80°C for 36 minutes, add 78.8g of honey, 5.25g of citric acid, and continue for 80 Heat and cook at ℃ for 5.3 minutes to complete the collection of paste, and then pour it into a clean container while it is hot, and keep it sealed.

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Abstract

The invention provides a traditional Chinese medicine ointment formula for treating chloasma and a preparation method and application thereof. The ointment formula is prepared from 35 medicinal materials; the basic pathogenesis is that liver Qi stagnation, deficiency of liver-Yin and kidney-Yin and weakness of spleen and stomach cause stasis turbidity to stop, stagnation of skin or empty vein and incapability of rising; according to the traditional Chinese medicine, chloasma takes deficiency (Qi deficiency, blood deficiency, spleen deficiency and deficiency of liver and kidney) and excess (Qi stagnation, dampness stagnation, liver depression and blood stasis) as pathogenesis, and the effects of tonifying deficiency and reducing excess, regulating Qi and blood, maintaining beauty and keeping young, and removing and fading spots are achieved. The whole formula is compatible to achieve the effects of soothing liver and strengthening spleen, promoting blood circulation to remove blood stasis, regulating Qi and blood, removing dampness and promoting tissue regeneration, and warming kidney Yang, so that the ointment formula is beneficial to eliminating plaques; and the formula has the effects of regulating liver, kidney and spleen, and does not have the problems of dryness-heat, greasy stagnation and the like.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicinal ointment for treating chloasma and its preparation method and application. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Melasma, also known as liver spots, is a yellow-brown pigmentation on the face. Multiple symmetrical butterflies are distributed on the cheeks. It is more common in women, and the main reason is high estrogen level in the blood. Its onset is related to pregnancy, long-term oral contraceptives, and menstrual disorders. Traditional Chinese medicine believes that the occurrence of chloasma is related to stagnation of liver qi, deficie...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/06A61K47/46A61K47/12A61P17/00A61K35/32A61K35/36
CPCA61K36/232A61K36/236A61K36/71A61K36/65A61K36/284A61K36/076A61K36/487A61K36/8969A61K36/64A61K36/54A61K36/533A61K36/39A61K36/43A61K36/481A61K36/752A61K36/9066A61K36/238A61K36/233A61K36/638A61K36/815A61K36/736A61K36/286A61K36/31A61K36/8984A61K36/575A61K36/804A61K36/9064A61K36/484A61K36/69A61K35/32A61K35/36A61K9/06A61K9/0053A61K47/46A61K47/12A61P17/00A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 赫爱平汪巍周书繁王辉杨玉
Owner LIAONING HUANREN PHARMA
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