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Cartridge injection box and its packaged methotrexate injection

A technology of methotrexate and cartridges, applied in the direction of syringes, ampoule syringes, hypodermic injection devices, etc., can solve the problems of children's physical injuries, short plasma half-life, and low concentration in target tissues, so as to reduce labor intensity and realize The effect of safe injection and avoiding waste

Active Publication Date: 2022-08-05
HUNAN HUIZE BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pharmacokinetic parameters reported in the literature, including peak concentration, peak time, area under the plasma concentration-time curve, and individual differences are between 30 and 90%. MTX is excreted by the kidneys in a short time after a large amount of administration, resulting in 5 ~8h short plasma half-life, low concentration in target tissues
The existing conventional preparations are injections and tablets, which have strong toxic and side effects such as gastrointestinal reactions, bone marrow suppression, and liver and kidney toxicity.
Especially in the process of administering methotrexate to children, the consequences of side effects caused by inaccurate dosing can be serious for children's physical damage

Method used

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  • Cartridge injection box and its packaged methotrexate injection
  • Cartridge injection box and its packaged methotrexate injection
  • Cartridge injection box and its packaged methotrexate injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] The existing cartridge-type bottle injection pen performs quantitative determination by rotating the components at the end of the pen. For example, when the user does not accurately grasp the injection amount, the quantitative inaccuracy is likely to occur. In addition, during the use of the existing cartridge-type injection pen, the movable plastic stopper in the cartridge is easy to bounce back, resulting in inaccurate measurement. In view of these shortcomings, the injection pen is specially improved, especially the quantitative method, to avoid the side effects caused by over-injection of methotrexate, and to ensure the multiple use of the injection in the cartridge and avoid the use of the drug solution. waste.

[0062] like figure 1 As shown, the present invention provides a cartridge-type bottle injection box for packaging methotrexate injection, comprising an injection box shell and an injection box box body connected by a rotating shaft; an injection pen is pl...

Embodiment 2

[0092] The difference from Embodiment 1 is that: the elastic member includes an elastic storage cavity and a pressing elastic member; the pressing elastic member itself has elasticity, and is stored into the elastic storage cavity under the action of external pressure, and automatically resets after the external pressure disappears. ; One end of the pressing elastic member is fixedly arranged in the lower end of the elastic receiving cavity, and the other end is far away from the elastic receiving cavity and the included angle thereof is 30-60°; the material of the pressing elastic member can be a U-shaped stainless steel sheet or a U-shaped elastic plastic sheet .

[0093] Content Example 1

[0094] A. Ingredient list (specification: 50mg / 2ml):

[0095]

[0096] B, the method for preparing injection:

[0097] Weigh 80% of the prescription water for injection, add the prescription amount of methotrexate, stir and disperse evenly, and then use 1% sodium citrate solution to...

Embodiment 3

[0110] A. Ingredient list (specification: 50mg / 2ml):

[0111]

[0112] B, the method for preparing injection:

[0113] Weigh 80% of the water for injection of the recipe, add methotrexate in the recipe, stir and disperse evenly, and then use 1% sodium hydroxide / hydrochloric acid solution to adjust the pH to 8-9;

[0114] Then add mannitol and phenol, stir evenly, and add water for injection to the full amount;

[0115] Then add 0.05% activated carbon for injection for adsorption; after adsorption, the solution is first filtered by activated carbon with a 0.8um filter membrane, and then filtered and sterilized with a 0.22um microporous filter membrane;

[0116] After filtration, 2ml of the filtrate is aseptically packaged in a cassette to obtain the finished product.

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Abstract

The invention belongs to the technical field of medical packaging and pharmaceutical preparations, and specifically discloses a cartridge-type vial injection box and a packaged methotrexate injection. The cartridge-type vial injection box is equipped with an injection pen, and the injection pen includes an injection Push rods, cartridges, injection racks, cartridge mounting sleeves and needle seat components. By improving the structure of the existing injection pen, a cartridge-type bottle injection box with a new structure is obtained, and it is ensured that the injection liquid packaged by the cartridge-type bottle injection box not only realizes the injection quantity, but also improves the injection safety, thereby reducing the bad MTX. response and increase its efficacy.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical packaging and pharmaceutical preparations, in particular to a cartridge-type bottle injection box and a packaged methotrexate injection. Background technique [0002] Traditional injections have been using ampoules for decades, the combination of cartridges and pen-type syringes. It is a new injection method developed in recent years that allows patients to use injections multiple times independently. It has been widely used. When applied to insulin injection products, compared with ampoule injection products, cartridge-type pen injection products have the following advantages: (1) There is no need to carry out irregular destructive opening treatment on the bottle during use, which can prevent breakage Part of the generated glass debris enters the medicinal liquid, and together with the medicinal liquid enters the human body and causes harm to the human body. (2) It can avoid the use of di...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M5/00A61M5/24A61M5/31A61K9/08A61K31/519A61K47/02A61K47/12A61P35/00A61P35/02
CPCA61K31/519A61K9/08A61K9/0019A61K47/12A61K47/02A61P35/00A61P35/02A61M5/002A61M5/24A61M5/31
Inventor 周群黄建国罗熙
Owner HUNAN HUIZE BIO PHARMA CO LTD
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