Whole liver bioartificial liver support system dedicated tubing

Abstract

This application provides a whole-liver type bioartificial liver system dedicated pipeline, including a plasma separation pipeline, a blood storage tank, a blood storage tank drainage line, a pre-hepatic pipeline, a post-hepatic pipeline and a whole liver perfusion device; The pipeline includes a plasma separation catheter and a plasma separation pump, and the plasma separation catheter is connected with the blood storage tank to input recipient plasma; the blood storage tank drainage line includes a blood drainage catheter and a blood drainage pump, and the prehepatic pipeline includes a prehepatic catheter, liver The posterior pipeline includes the retrohepatic catheter, the blood drainage catheter, the prehepatic catheter and the retrohepatic catheter are connected sequentially in the direction from the output end of the blood storage tank to the input end, and the whole liver perfusion device is set between the anterior hepatic catheter and the retrohepatic catheter; The blood storage tank lead tube, pre-hepatic line, post-hepatic line and whole liver perfusion device constitute an extracorporeal liver perfusion cycle, and the plasma separation line and extracorporeal liver perfusion cycle are connected in parallel through the blood storage tank. The special pipeline provided by the present invention is adapted to the whole-liver bioartificial liver system, can realize the docking of various equipment in the system, and is easy to install.

Description

technical field [0001] This application relates to the field of medical devices, in particular to a dedicated pipeline for a whole-liver bioartificial liver support system. Background technique [0002] Bioartificial liver support system, as a "bridge therapy" method for liver failure waiting for liver source or liver self-regeneration, is a hot research topic at present. At present, artificial liver support system mainly includes biological artificial liver support system, non-biological artificial liver support There are three types of systemic and combined bioartificial liver support systems, among which the bioartificial liver is divided into hepatocyte type and whole liver type according to the different reactors. Based on the concept that the best artificial liver support is the liver itself, the whole liver bioreactor has a richer number of functional cells, the best three-dimensional cell conformation and better cost-effectiveness, and the clinical application has su...

AI Technical Summary

Problems solved by technology

However, the current whole-liver artificial liver system has problems such as system complexity and poor liver perfusion, which limit its further popularization and application.

[0003] In addition, the current whole-liver bioartificial liver system does not have matching pipelines. In order to realize the mutual cooperation of different treatment modes, it is often necessary to disassemble and reconnect the pipelines according to actual needs, and the current pipelines are not suitable. Whole-liver bioartificial liver, resulting in inconvenient assembly and disassembly of pipeline connections and complex structure

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