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Aloe arborescens-chitosan-graphene oxide gel freeze-dried powder for burns

A technology of graphene gel and graphene powder, which is applied in the direction of freeze-drying transportation, powder transportation, medical preparations of non-active ingredients, etc., and can solve problems such as wound adhesion, poor air permeability and comfort, and secondary injury of wounds , to achieve the effect of preventing peritoneal adhesion, preventing bleeding and promoting erythrocyte sedimentation rate

Active Publication Date: 2021-04-02
山东爱维德生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the problems that the existing dressings for burns are faced with poor air permeability and comfort, easy to cause wound adhesion, and secondary damage to the wound, the purpose of the present invention is to provide a kind of Aloe arborescens-chitosan- Graphene oxide lyophilized powder

Method used

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  • Aloe arborescens-chitosan-graphene oxide gel freeze-dried powder for burns
  • Aloe arborescens-chitosan-graphene oxide gel freeze-dried powder for burns

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preparation example Construction

[0049] The present invention also includes a preparation method of Aloe arborescens-chitosan-graphene oxide gel freeze-dried powder for burns, comprising the following steps:

[0050] (1) In parts by weight, take 1 to 2 parts of chitosan-modified graphene oxide and 0.3 to 0.5 parts of Aloe arborescens extract, add them to 100 parts of water, heat up to 25 to 35°C, and put them at a speed of 100 rpm Stir for 2 to 4 hours to obtain solution 1;

[0051] (2) Add 0.5-0.7 parts of sodium hyaluronate and 0.6-0.8 parts of polyethylene glycol to Solution 1, maintain the temperature at 15-25°C, and stir for 1-2 hours to obtain Solution 2;

[0052] (3) Add 0.03 to 0.05 parts of allantoin, 0.06 to 0.12 parts of lecithin, 0.01 to 0.02 parts of recombinant human epidermal growth factor, and 0.02 to 0.03 parts of hydroxyacetophenone to solution 2, ultrasonic for 10 to 30 minutes, and maintain the temperature at 15 ~25°C, stir for 10-30 minutes, add 0.1-0.15 parts of polyvinylpyrrolidone, st...

Embodiment 1

[0057] Preparation of Aloe arborescens Extract

[0058] According to the method disclosed in the patent CN1313112A to prepare Aloe arborescens extract, weigh 100g of fresh Aloe arborescens leaves, peel and crush to obtain jelly, heat the jelly to 40°C, add 60mg of pectinase, and stir at constant temperature for 3 hours , filtered, and the filtrate was concentrated to one-tenth of the original volume with a reverse osmosis membrane, and freeze-dried at -50°C to obtain the Aloe arborescens extract.

Embodiment 2

[0060] Preparation of chitosan-modified graphene oxide:

[0061] ①Add 10g of graphene oxide to 2000g of N,N-dimethylformamide, add 5g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 4g of N-hydroxy Succinimide, stirred for 1 hour, added 10 g of chitosan, heated to 50 ° C, stirred and reacted for 12 hours, dialyzed with a dialysis bag with a molecular weight of 3500 for 48 hours, and freeze-dried to obtain chitosan-modified graphene oxide powder;

[0062] ② Take the chitosan-modified graphene oxide powder obtained in step ①, add it to 2000g of water, stir at a speed of 100 rpm for 10 minutes, add 20g of acetic acid dropwise at a temperature of 20°C, and finish dropping in 20 minutes. Continue to stir for 2 hours and freeze-dry to obtain chitosan-modified graphene oxide.

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Abstract

The invention discloses aloe arborescens-chitosan-graphene oxide gel freeze-dried powder for burns. The aloe arborescens-chitosan-graphene oxide gel freeze-dried powder is prepared from the followingraw materials: chitosan modified graphene oxide, sodium hyaluronate, an aloe arborescens extract, allantoin, lecithin, recombinant human epidermal growth factors and the like. The chitosan and the graphene oxide are used as raw materials to prepare chitosan modified graphene oxide, when used for preparing the aloe arborescens-chitosan-graphene oxide composite gel material, the chitosan modified graphene oxide expands in water to absorb water and can effectively adsorb various active substances in the aloe arborescens extract, for example, the chitosan can adsorb hydrophilic active substances of mucopolysaccharides in the aloe arborescens extract, and the graphene oxide can adsorb flavonoid compounds containing benzene rings in aloes arborescens through pi-pi accumulation and has a good adsorption effect on various trace elements in the aloe arborescens.

Description

technical field [0001] The invention relates to the technical field of medicinal gel freeze-dried powder products, in particular to an aloe arborescens-chitosan-graphene oxide freeze-dried powder for burns, and the invention also includes a preparation method of the gel freeze-dried powder. Background technique [0002] Burns are skin injuries caused by skin contact with extreme heat, extreme cold, chemicals, etc., resulting in the destruction of the body's first barrier against viral infection, while body fluids seep around the wound, providing a good environment for the growth of viruses and bacteria , cause sepsis and other viral infections, and large area burns on the human body can easily cause death. The medical materials used clinically to treat burns are generally dressings, which are woven from cotton fibers. By wrapping the burn wound to isolate external bacteria and prevent infection, at the same time, apply antibacterial and wound healing drugs on the wound to pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61K9/19A61K47/36A61K47/04A61K47/32A61K47/24A61K47/10A61P17/02A61K36/896A61K36/886A61K31/722A61K31/685
CPCA61K36/896A61K36/886A61K38/1808A61K31/722A61K31/685A61K9/19A61K9/0014A61K47/36A61K47/02A61K47/32A61K47/24A61K47/10A61P17/02A61K2300/00
Inventor 张海峰赖培錡马启冠潘殿玲
Owner 山东爱维德生物科技有限公司
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