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Composition for treating peripheral neuropathy induced by chemotherapy and application of composition

A peripheral neuropathy and composition technology, which is applied in the field of peripheral neuropathy compositions, can solve problems such as complex mechanisms, and achieve the effects of inhibiting overexpression, significant treatment, and enhancing resistance

Active Publication Date: 2021-03-26
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complexity of the mechanism of CIPN and the limitations of existing therapeutic drugs, finding new therapeutic drugs has become an urgent clinical problem to be solved.

Method used

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  • Composition for treating peripheral neuropathy induced by chemotherapy and application of composition
  • Composition for treating peripheral neuropathy induced by chemotherapy and application of composition
  • Composition for treating peripheral neuropathy induced by chemotherapy and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A composition for treating peripheral neuropathy in chemotherapy, composed of ginsenoside RG1 and fucoste polysaccharide, ginsenoside RG1 purity ≥ 95%, fucose polysaccharide purity ≥95%, particles and diameters have no special requirements. The mass ratio of ginsenoside RG1 and franuclear polysaccharides is 1: 1.

[0032] Preparation method: 40 mg of ginsenoside RG1 powder and 40 mg of fucose polysin powder were dissolved in 5 ml of sterile water, and vortexed, which made it mixed and completely dissolved.

Embodiment 2

[0034]A composition for treating peripheral neuropathy in chemotherapy, composed of ginsenoside RG1 and fucoste polysaccharide, and ginsenoside RG1 purity ≥ 95%, fucose polysaccharide purity ≥ 95%, particles and diameters have no special requirements. The mass ratio of ginsenoside RG1 and franuclear polysaccharides is 1: 5.

[0035] Preparation method: 40 mg of ginsenoside RG1 powder and 200 mg of fucose polysin powder were dissolved in 5 ml of sterile water, and vortexed, which made it mixed and completely dissolved.

Embodiment 3

[0037] A composition for treating peripheral neuropathy in chemotherapy, composed of ginsenoside RG1 and fucoste polysaccharide, and ginsenoside RG1 purity ≥ 95%, fucose polysaccharide purity ≥ 95%, particles and diameters have no special requirements. The mass ratio of ginsenoside RG1 and franuclear is 1: 2.5.

[0038] Preparation method: 40 mg of ginsenoside RG1 powder and 100 mg of fucoste polysin powder were dissolved in 5 ml of sterile water, and vortexed, which made it mixed and completely dissolved.

[0039] Effect of CIPN in the composition of the present invention

[0040] Experimental program:

[0041] 1 Experimental animals: Male C57BL / 6J mice and male ICR mice, SPF level, 6-8 weeks old, provided by Shanghai Municipal Family Plastic Science Research Institute Experimental Animal Business Department, SR-A KO Mouse by Nanjing Medical University Professor Qi Hui gave a gift from the Nanjing Medical University Experimental Animal Center. ICR mice, C57BL / 6J mice were use...

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Abstract

The invention provides a composition for treating peripheral neuropathy induced by chemotherapy and application of the composition, and belongs to the field of medicines. The composition for treatingperipheral neuropathy induced by chemotherapy comprises ginsenoside Rg1 and fucoidin. The composition can obviously inhibit the expression of proinflammatory factors such as TNF-alpha, IL-1beta and IL-6, so that the effects of resisting inflammation, promoting repair and enhancing resistance are achieved on peripheral nerves; and besides, the composition can significantly improve microcirculationdisturbance, the up-regulation of SR-A expression is achieved, the phagocytic and clearance capacity of macrophages to HMGB1 is enhanced, the TF over-expression is inhibited, microcirculation disturbance and neuropathic pain caused by chemotherapeutic drugs are relieved through multiple targets and multiple mechanisms, the development of CIPN is fundamentally inhibited, the purpose of safe and effective treatment is achieved, and a new treatment strategy is provided for clinic.

Description

Technical field [0001] The present invention belongs to the medical field, and more particularly to compositions for the treatment of chemotherapy induced peripheral neuropathy and their applications. Background technique [0002] Tumor is a disease that seriously endangers human health, which is very difficult. Although there are some targeted drugs, chemotherapy is still one of the most commonly used methods for treating malignant tumors. Regrettably, chemotherapy often brings serious side effects, such as pain, vomiting, dizziness, and hair loss. Especially pain, it will make patients be more anxious and even depressed, which will seriously affect the patient's mental state, and ultimately hinder the treatment of tumors. In the side effects of tumors, Chemotherapy-Induced Peripheral Neuropathy, CIPN, resulting in chemotherapy, is a very painful reaction, mainly manifested to feel abnormalities, especially for cold tactile hypersensitivity and mechanical hypersensitivity. Pain,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K31/715A61P25/02A61P29/00
CPCA61K31/704A61K31/715A61P25/02A61P43/00A61K2300/00Y02A50/30
Inventor 刘文涛陈琪李岩姜春懿胡亮吴雪丰王玉林彤彤贾茹梦
Owner NANJING MEDICAL UNIV
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