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Eye drops containing netilmicin sulfate and preparation method of eye drops

A technology of netilmicin sulfate and eye drops, which is applied in the field of medicine, can solve the problems of complex preparation components, difficult industrial production, and no eye preparations, etc., and achieves the effects of high production efficiency and simple preparation process.

Inactive Publication Date: 2021-03-26
ZHUOHE PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Netilmicin sulfate has a good effect on various ophthalmic infections caused by sensitive bacteria, but there is no ophthalmic preparation for clinical use
The 2002 patent (ZL02138662.5) disclosed the application of a netilmicin sulfate in the preparation of eye drops, but this technology has not yet been used clinically
In addition to the main raw material netilmicin sulfate, this patent also includes antioxidants, antioxidant synergists, preservatives, pH regulators, isotonic regulators, stabilizers and solvents. Preservation of the main drug is easy to react with various excipients, and it is not easy to industrialized production and other disadvantages

Method used

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Examples

Experimental program
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preparation example Construction

[0019] The present invention also discloses a preparation method of the above-mentioned eye drops, which comprises the following steps:

[0020] Step 1): Measure netilmicin sulfate, add 200ml of purified water, and stir until completely dissolved;

[0021] Step 2): Add a prescribed amount of preservative to the solution obtained in step 1), stir well, filter, rinse the filter membrane with purified water, and collect the filtrate and rinse solution;

[0022] Step 3): Weigh the isotonic regulator of the prescribed amount, dissolve it with purified water, and filter;

[0023] Step 4): Add the filtrate and flushing solution in step 2) to the isotonic regulator solution in step 3), make up to 1000ml with purified water, filter, measure the content, and distribute it in eye drop bottles to obtain .

Embodiment 1

[0026] The eye drops containing netilmicin sulfate disclosed in this example mainly include: 2 g of netilmicin sulfate, 2 g of benzalkonium bromide solution, 10 g of sodium chloride, and 1000 ml of purified water.

[0027] Preparation method: Accurately measure 2g of netilmicin sulfate, add 200ml of purified water, stir until completely dissolved, add 2g of benzalkonium bromide, stir well, filter through a 0.22μm microporous membrane, rinse the filter with about 50ml of purified water Membrane, collect filtrate and washing solution for later use.

[0028] Accurately weigh 10 g of isotonic regulator sodium chloride, dissolve in 200 ml of purified water, and filter with a 0.22 μm microporous membrane.

[0029] Add the filtrate and flushing solution to the isotonic regulator solution, make up to 1000ml with purified water, filter it with a 0.22μm microporous membrane, measure the content, and distribute it in sterilized dry eye drop bottles to obtain .

Embodiment 2

[0031] The eye drops containing netilmicin sulfate disclosed in this embodiment mainly include: 3 g of netilmicin sulfate, 3 g of benzalkonium bromide solution, 9 g of sodium chloride, and purified water to 1000 ml.

[0032] Preparation method: Accurately measure 3g of netilmicin sulfate, add 200ml of purified water, stir until completely dissolved, add 3g of benzalkonium bromide, stir well, filter through a 0.22μm microporous membrane, rinse the filter with about 50ml of purified water Membrane, collect filtrate and washing solution for later use.

[0033] Accurately weigh 9 g of isotonic regulator sodium chloride, dissolve in 200 ml of purified water, and filter with a 0.22 μm microporous membrane.

[0034] Add the filtrate and flushing solution to the isotonic regulator solution, make up to 1000ml with purified water, filter it with a 0.22μm microporous membrane, measure the content, and distribute it in sterilized dry eye drop bottles to obtain .

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Abstract

The invention discloses eye drops containing netilmicin sulfate. Every 1000ml of the eye drops comprises the following components: 1-10g of netilmicin sulfate, 60-80g of a preservative, 1-10g of an isoosmotic adjusting agent and the balance of purified water. In the eye drops provided by the invention, netilmicin sulfate is used as a main drug, and the preservative, the isoosmotic adjusting agentand the purified water are used as auxiliary materials. The whole preparation process is simple, the production efficiency is high, and the eye drops can be used for treating various eye infections sensitive to netilmicin.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical technology, in particular to an eye drop containing netilmicin sulfate. Background technique [0002] Netilmicin sulfate has a good effect on various ophthalmic infections caused by sensitive bacteria, but there is no ophthalmic preparation for clinical use. The 2002 patent (ZL02138662.5) disclosed the application of a netilmicin sulfate in the preparation of eye drop preparations, but this technology has not yet been used clinically. In addition to the main raw material netilmicin sulfate, this patent also includes antioxidants, antioxidant synergists, preservatives, pH regulators, isotonic regulators, stabilizers and solvents. Preservation of the main drug is easy to react with various auxiliary materials, and it is not easy to industrialized production and other disadvantages. Contents of the invention [0003] The object of the present invention is to provide an eye drop containing ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7048A61P27/02A61P31/04
CPCA61K31/7048A61K9/08A61K9/0048A61P31/04A61P27/02
Inventor 李晓明司恋飞曹娜孙益林
Owner ZHUOHE PHARM GRP CO LTD
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