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Preparation method and application of drug-coated balloon catheter

A technology of balloon catheter and drug coating, which is applied in the direction of balloon catheters and catheters, can solve the problems of low drug utilization rate and release rate, poor drug effect persistence and absorption effect, and is conducive to wide application and reduction Drug loss rate, effect of material availability

Active Publication Date: 2021-10-08
融冲(深圳)生物医疗科技有限责任公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of this application is to provide a preparation method and application of a drug-coated balloon catheter, aiming to solve the problem of low drug utilization and release rate, poor drug persistence and poor absorption effect during the use of drug balloons in the prior art The problem

Method used

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  • Preparation method and application of drug-coated balloon catheter
  • Preparation method and application of drug-coated balloon catheter
  • Preparation method and application of drug-coated balloon catheter

Examples

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preparation example Construction

[0029] The first aspect of the embodiment of the present application provides a method for preparing a drug-coated balloon catheter, comprising the following steps:

[0030] S01. Provide a drug coating solution and a balloon catheter, and inflate the balloon catheter to obtain a three-dimensional balloon catheter;

[0031] S02. Spraying the drug coating solution onto the surface of the three-dimensional balloon catheter by means of ultrasonic atomization and spraying to obtain the coarse material of the drug-coated balloon catheter;

[0032] S03. Provide a crystallization reagent solution, place the crude material of the drug-coated balloon catheter and the crystallization reagent solution in a sealed container for fumigation and crystallization treatment, form crystals attached to the three-dimensional balloon catheter, and obtain a drug-coated balloon catheter .

[0033] The preparation method of the drug-coated balloon catheter provided in the first aspect of the present a...

Embodiment 1

[0073] Preparation method of drug-coated balloon catheter to prepare drug-coated balloon catheter

[0074] The preparation method comprises the following steps:

[0075] Provide a drug coating solution: add the active drug rapamycin and the carrier dibutyl hydroxytoluene to isopropanol, and dissolve them in an ultrasonic way to obtain a drug coating solution, wherein the concentration of the active drug rapamycin is 30mg / ml, the agent concentration of carrier dibutyl hydroxytoluene is: 3mg / ml;

[0076] Provide balloon catheter: After the balloon catheter is connected to a Luer connector, then a one-way valve is connected. After the gas is pressed through the one-way valve, the gas passes through the Luer connector, and then the product is inflated. The one-way valve and the After the gas is cut off, the balloon is always inflated because the one-way valve only inhales air but not air, and a three-dimensional balloon catheter is obtained. The inflation pressure of the three-d...

Embodiment 2

[0081] Preparation method of drug-coated balloon catheter to prepare drug-coated balloon catheter

[0082] The preparation method comprises the following steps:

[0083] Provide a drug coating solution: add the active drug rapamycin and the carrier dibutylhydroxytoluene into isopropanol, and dissolve them in an ultrasonic way to obtain a drug coating solution, in which the concentration of the active drug rapamycin is 32 mg / ml, the agent concentration of carrier dibutyl hydroxytoluene is 2mg / ml;

[0084] Provide balloon catheter: After the balloon catheter is connected to a Luer connector, then a one-way valve is connected. After the gas is pressed through the one-way valve, the gas passes through the Luer connector, and then the product is inflated. The one-way valve and the After the gas is cut off, the balloon is always inflated because the one-way valve only inhales air but not air, and a three-dimensional balloon catheter is obtained. The inflation pressure of the three...

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Abstract

This application relates to the technical field of medical devices, and provides a method for preparing a drug-coated balloon catheter. The method uses the three-dimensional balloon catheter obtained by inflating treatment as a raw material, and sequentially adopts the methods of ultrasonic atomization spraying and fumigation crystallization treatment. treatment to form crystals attached to the three-dimensional balloon catheter. This preparation method can reduce the loss rate of drugs during the intervention process and ensure that more drugs are used for treatment; at the same time, it improves the release rate of drugs so that drugs can quickly act on cells Improve the retention time of the drug in the body, make the drug act on the cells for a long time, reduce the metabolic rate of the drug, promote the absorption of the drug, and achieve a long-term therapeutic effect. At the same time, the preparation method has easy-to-obtain materials, is simple and easy to operate, has clear steps, and is favorable for wide application.

Description

technical field [0001] The application belongs to the technical field of medical devices, and in particular relates to a preparation method and application of a drug-coated balloon catheter. Background technique [0002] Drug-coated balloon catheter, which is a rapid-exchange PTCA balloon catheter with a drug-releasing balloon system, is a new type of therapeutic balloon drug developed on the basis of interventional techniques such as balloon dilatation or balloon angioplasty Release technology, which is to apply anti-proliferative drugs on the surface of the balloon. When the balloon reaches the blood vessel wall of the lesion, it is stretched and expanded. When it contacts the intima of the blood vessel wall, the drug is released quickly and transferred locally The technology in the blood vessel wall, the drug plays the role of anti-intimal hyperplasia locally, so as to prevent the restenosis of blood vessels after vascular intervention. treat. [0003] There are many me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M25/10
CPCA61M25/1029A61M2025/1031A61M2025/105
Inventor 黄芳英蔡凌燕曹波梁世豪
Owner 融冲(深圳)生物医疗科技有限责任公司
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