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Traditional Chinese medicine composition capable of resisting staphylococcus aureus and a drug-resistant strain thereof and preparation method and application of traditional Chinese medicine composition

A staphylococcus, golden yellow technology, applied in antibacterial drugs, pharmaceutical formulations, plant raw materials, etc., can solve the problem of no reports of compound anti-Staphylococcus aureus drug-resistant bacteria MRSA, yet to be retrieved, etc.

Active Publication Date: 2021-03-19
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the clinical treatment of infectious diseases, antibiotics have been widely used, but antibiotic resistance, iatrogenic complications and allergic reactions are limiting their use
At present, there is no research report on the anti-Staphylococcus aureus compound prescription of Magnolia officinalis, Galla gall, Scutellaria baicalensis and Benzoin, let alone the report of the compound prescription against the drug-resistant Staphylococcus aureus MRSA

Method used

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  • Traditional Chinese medicine composition capable of resisting staphylococcus aureus and a drug-resistant strain thereof and preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition capable of resisting staphylococcus aureus and a drug-resistant strain thereof and preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition capable of resisting staphylococcus aureus and a drug-resistant strain thereof and preparation method and application of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A traditional Chinese medicine composition for resisting staphylococcus aureus and drug-resistant strains thereof, comprising the following components in parts by volume: 10 parts of magnolia bark extract, 10 parts of gallnut extract, 20 parts of scutellaria baicalensis extract and 10 parts of benzoin extract.

[0043] The above extracts of Magnolia officinalis officinalis bark, Galla gallinaceae, Scutellaria baicalensis and Benzoin were all prepared by the following method: Magnolia officinalis, Galla galla, Scutellaria baicalensis and Benzoin were crushed into 2mm particles respectively, then 70% ethanol was added for ultrasonic dispersion for 30min, and then Extract at 30°C for 30 days and filter to obtain Magnolia officinalis extract, Galla gallinacea extract, Scutellaria baicalensis extract and Benzoin extract; the ratio of solid to liquid is 1:4g / mL.

[0044] The preparation method of the anti-Staphylococcus aureus traditional Chinese medicine composition includes:...

Embodiment 2

[0046] A traditional Chinese medicine composition for resisting staphylococcus aureus and drug-resistant strain thereof, comprising the following components in parts by volume: 10 parts of magnolia bark extract, 20 parts of gallnut extract, 20 parts of scutellaria baicalensis extract and 10 parts of benzoin extract.

[0047] The above extracts of Magnolia officinalis officinalis bark, Galla gallinaceae, Scutellaria baicalensis and Benzoin were all prepared by the following method: Magnolia officinalis, Galla galla, Scutellaria baicalensis and Benzoin were crushed into 2mm particles respectively, then 70% ethanol was added for ultrasonic dispersion for 30min, and then Extract at 30°C for 30 days and filter to obtain Magnolia officinalis extract, Galla gallinacea extract, Scutellaria baicalensis extract and Benzoin extract; the ratio of solid to liquid is 1:4g / mL.

[0048] The preparation method of the anti-Staphylococcus aureus traditional Chinese medicine composition includes: ...

Embodiment 3

[0050] A traditional Chinese medicine composition for resisting staphylococcus aureus and drug-resistant strains thereof, comprising the following components in parts by volume: 10 parts of magnolia bark extract, 40 parts of gallnut extract, 40 parts of scutellaria baicalensis extract and 40 parts of benzoin extract.

[0051] The above extracts of Magnolia officinalis officinalis bark, Galla gallinaceae, Scutellaria baicalensis and Benzoin were all prepared by the following method: Magnolia officinalis, Galla galla, Scutellaria baicalensis and Benzoin were crushed into 2mm particles respectively, then 70% ethanol was added for ultrasonic dispersion for 30min, and then Extract at 30°C for 30 days and filter to obtain Magnolia officinalis extract, Galla gallinacea extract, Scutellaria baicalensis extract and Benzoin extract; the ratio of solid to liquid is 1:4g / mL.

[0052] The preparation method of the anti-Staphylococcus aureus traditional Chinese medicine composition includes:...

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Abstract

The invention provides a traditional Chinese medicine composition capable of resisting staphylococcus aureus and a drug-resistant strain thereof and a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components in parts by volume: 10-40 parts of cortex magnolia officinalis extract, 10-40 parts of galla chinensis extract, 10-40 parts of radix scutellariae extract and 10-40 parts of benzoin extract. According to the traditional Chinese medicine composition, cortex magnoliae officinalis and galla chinensis are taken as main antibacterial components, and compatible traditional Chinese medicines including radix scutellariae and benzoin based on the effects of diminishing inflammations, easingpain, inhibiting bacteria, removing toxin and the like as auxiliary medicinal materials, so that the medicinal materials synergistically exert the best antibacterial effect on the staphylococcus aureus and the drug-resistant strain thereof, and the medicinal materials used in the formula do not contain toxic medicinal materials, so that the traditional Chinese medicine composition has the characteristics of high safety and small toxic and side effects.

Description

technical field [0001] The invention belongs to the technical field of antibacterial drugs, and in particular relates to a traditional Chinese medicine composition for resisting Staphylococcus aureus and drug-resistant strains thereof, a preparation method and application thereof. Background technique [0002] Staphylococcus aureus (Staphylococcus aureus), also known as Staphylococcus aureus, is an important pathogenic bacteria belonging to the genus Staphylococcus (Staphylococcus). Staphylococcus aureus is ubiquitous in nature and can be found in air, water, dust, and human and animal excrement. It is the most common pathogen in human suppurative infections and can cause human and animal diseases, including skin infections. , pneumonia, enteritis, endocarditis, and more serious diseases such as sepsis and toxic shock. Usually, antibiotics are used clinically to treat Staphylococcus aureus infection. Due to the role of antibiotics in destroying bacteria and inhibiting bacte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/575A61P31/04A61K35/64
CPCA61K36/575A61K35/64A61K36/539A61K36/185A61P31/04A61K2236/333A61K2300/00
Inventor 茆灿泉王隽敖智广王思怡李迪强李栋杨蕾
Owner SOUTHWEST JIAOTONG UNIV
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