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A kind of anti-Staphylococcus aureus and its drug-resistant strain traditional Chinese medicine composition and its preparation method and application

A staphylococcus, golden yellow technology, applied in antibacterial drugs, pharmaceutical formulations, plant raw materials, etc., can solve the problem of no reports of compound anti-Staphylococcus aureus drug-resistant bacteria MRSA, yet to be retrieved, etc.

Active Publication Date: 2022-05-24
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the clinical treatment of infectious diseases, antibiotics have been widely used, but antibiotic resistance, iatrogenic complications and allergic reactions are limiting their use
At present, there is no research report on the anti-Staphylococcus aureus compound prescription of Magnolia officinalis, Galla gall, Scutellaria baicalensis and Benzoin, let alone the report of the compound prescription against the drug-resistant Staphylococcus aureus MRSA

Method used

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  • A kind of anti-Staphylococcus aureus and its drug-resistant strain traditional Chinese medicine composition and its preparation method and application
  • A kind of anti-Staphylococcus aureus and its drug-resistant strain traditional Chinese medicine composition and its preparation method and application
  • A kind of anti-Staphylococcus aureus and its drug-resistant strain traditional Chinese medicine composition and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0042] A traditional Chinese medicine composition against Staphylococcus aureus and its drug-resistant strains comprises the following components by volume: 10 parts of Magnolia officinalis extract, 10 parts of gall extract, 20 parts of Scutellaria baicalensis extract and 10 parts of benzoin extract.

[0043] The above-mentioned Magnolia bark extract, Galla japonica extract, Scutellaria baicalensis extract and Benzoin extract were all prepared by the following methods: respectively crushing Magnolia Bark, Galla japonica, Scutellaria baicalensis and Benzoin into 2mm particles, then adding 70% ethanol to ultrasonically disperse for 30min, and then adding Extraction at 30° C. for 30 days, and filtering to obtain Magnolia Bark Extract, Galla Fructus Extract, Scutellariae Scutellariae Extract and Benzoin Extract; wherein the ratio of material to liquid is 1:4 g / mL.

[0044] The preparation method of the above-mentioned anti-Staphylococcus aureus traditional Chinese medicine composit...

Embodiment 2

[0046] A traditional Chinese medicine composition against Staphylococcus aureus and its drug-resistant strains comprises the following components by volume: 10 parts of Magnolia officinalis extract, 20 parts of gall extract, 20 parts of Scutellaria baicalensis extract and 10 parts of benzoin extract.

[0047] The above-mentioned Magnolia bark extract, Galla japonica extract, Scutellaria baicalensis extract and Benzoin extract were all prepared by the following methods: respectively crushing Magnolia Bark, Galla japonica, Scutellaria baicalensis and Benzoin into 2mm particles, then adding 70% ethanol to ultrasonically disperse for 30min, and then adding Extraction at 30° C. for 30 days, and filtering to obtain Magnolia Bark Extract, Galla Fructus Extract, Scutellariae Scutellariae Extract and Benzoin Extract; wherein the ratio of material to liquid is 1:4 g / mL.

[0048] The preparation method of the above-mentioned anti-Staphylococcus aureus traditional Chinese medicine composit...

Embodiment 3

[0050] A traditional Chinese medicine composition against Staphylococcus aureus and its drug-resistant strains comprises the following components by volume: 10 parts of Magnolia officinalis extract, 40 parts of gall extract, 40 parts of Scutellaria baicalensis extract and 40 parts of benzoin extract.

[0051] The above-mentioned Magnolia bark extract, Galla japonica extract, Scutellaria baicalensis extract and Benzoin extract were all prepared by the following methods: respectively crushing Magnolia Bark, Galla japonica, Scutellaria baicalensis and Benzoin into 2mm particles, then adding 70% ethanol to ultrasonically disperse for 30min, and then adding Extraction at 30° C. for 30 days, and filtering to obtain Magnolia Bark Extract, Galla Fructus Extract, Scutellariae Scutellariae Extract and Benzoin Extract; wherein the ratio of material to liquid is 1:4 g / mL.

[0052] The preparation method of the above-mentioned anti-Staphylococcus aureus traditional Chinese medicine composit...

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Abstract

The invention provides an anti-Staphylococcus aureus and its drug-resistant strain Chinese medicine composition and its preparation method and application. The Chinese medicine composition comprises the following components by volume: 10-40 parts of Magnolia officinalis extract, gallnut extract 10‑40 parts, Scutellaria baicalensis extract 10‑40 parts and Benzoin extract 10‑40 parts. The traditional Chinese medicine composition uses magnolia officinalis and gallnut as the main antibacterial ingredients, and is compatible with traditional Chinese medicines such as scutellaria baicalensis and benzoin based on anti-inflammatory, analgesic, bacteriostatic, and detoxifying effects as auxiliary medicinal materials, and has a synergistic effect on Staphylococcus aureus and its drug-resistant strains. It has the best antibacterial effect, and the medicinal materials used in the prescription do not contain toxic medicinal materials, and has the characteristics of high safety and small toxic and side effects.

Description

technical field [0001] The invention belongs to the technical field of antibacterial drugs, and in particular relates to a traditional Chinese medicine composition against Staphylococcus aureus and drug-resistant strains thereof, and a preparation method and application thereof. Background technique [0002] Staphylococcus aureus, also known as Staphylococcus aureus, is an important pathogenic bacteria belonging to the genus Staphylococcus. Staphylococcus aureus is ubiquitous in nature and can be found in the air, water, dust and excrement of humans and animals. It is the most common pathogen in human purulent infections and can cause human and animal diseases, including skin infections. , pneumonia, enteritis, endocarditis, and more serious diseases such as sepsis and toxic shock. Generally, antibiotics are used in clinical treatment of Staphylococcus aureus infections, and due to their role in destroying bacteria and inhibiting bacterial growth, antibiotics cause huge sur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/575A61P31/04A61K35/64
CPCA61K36/575A61K35/64A61K36/539A61K36/185A61P31/04A61K2236/333A61K2300/00
Inventor 茆灿泉王隽敖智广王思怡李迪强李栋杨蕾
Owner SOUTHWEST JIAOTONG UNIV
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