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Polystyrene latex microspheres and preparation method thereof

A technology of polystyrene latex and styrene monomer, which is applied in the direction of instruments, analytical materials, measuring devices, etc., can solve the problems of coupling failure coupling efficiency, poor improvement effect, and reduce the stability of latex microspheres, etc., to achieve Improve the coupling success rate and coupling efficiency, high particle size uniformity, small particle size effect

Active Publication Date: 2021-03-16
SICHUAN ANKERUI NEW MATERIAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the coupling process of traditional polystyrene latex microspheres with specific substances, agglutination is more common, and agglutination may easily lead to coupling failure or low coupling efficiency
There are methods to improve the stability of latex microspheres by modifying appropriate hydrophilic groups on polystyrene, but this method can only reduce the stability of latex microspheres during storage. For polystyrene latex microspheres Poor effect on improvement of agglutination during coupling with specific substances

Method used

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  • Polystyrene latex microspheres and preparation method thereof
  • Polystyrene latex microspheres and preparation method thereof
  • Polystyrene latex microspheres and preparation method thereof

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preparation example Construction

[0054] The present invention also provides the preparation method of above-mentioned polystyrene latex microsphere, comprises the steps:

[0055] Mix the preparation raw materials and water, heat and stir to carry out emulsion polymerization.

[0056]In one example, mixing the preparation materials refers to adding the surfactant to the water, heating and stirring, and then adding the rest of the preparation materials.

[0057] In one example, heating and stirring refers to stirring at a rate of 80 rpm to 500 rpm under the temperature condition of 65° C. to 95° C.

[0058] Specifically, the temperature of heating and stirring includes but not limited to the following temperatures: 65°C, 70°C, 75°C, 78°C, 80°C, 82°C, 85°C, 90°C, 95°C.

[0059] The stirring rate includes but not limited to the following rates: 80rpm, 100rpm, 150rpm, 200rpm, 250rpm, 300rpm, 350rpm, 380rpm, 400rpm, 420rpm, 450rpm, 500rpm.

[0060] The present invention also provides the application of the above-...

Embodiment 1

[0071] The present embodiment provides a kind of polystyrene latex microsphere, and its preparation raw material and method are as follows:

[0072] (1) Put 7 grams of styrene, 50 mL of water, 0.2 grams of methacrylic acid, 0.03 grams of sodium dodecylbenzenesulfonate, and 0.17 grams of Triton X-100 into a 100 mL four-necked flask with a stirrer, and Under the conditions of 80 ° C and a stirring rate of 400 rpm, the polymerization reaction was carried out for 1 hour;

[0073] (2) 0.1 g of potassium persulfate was added to the reaction system, and further polymerized at 80° C. and a stirring rate of 400 rpm for 8 hours to obtain polystyrene latex microspheres with an average particle size of 89.57 nm.

Embodiment 2

[0075] The present embodiment provides a kind of polystyrene latex microsphere, and its preparation raw material and method are the same as embodiment 1, and the main difference is: change 0.17 gram of Triton X-100 to Tween-20 0.3 gram (in order to guarantee microsphere The diameters are basically the same, and non-equal mass replacements are used).

[0076] details as follows:

[0077] (1) Put 7 grams of styrene, 50 mL of water, 0.2 grams of methacrylic acid, 0.03 grams of sodium dodecylbenzene sulfonate, and 200.3 grams of Tween into a 100 mL four-necked flask with a stirrer. Polymerization was carried out for 1 hour at 80°C and a stirring rate of 400rp;

[0078] (2) 0.1 g of potassium persulfate was added to the reaction system, and further polymerization was carried out at 80° C. and a stirring rate of 400 rpm for 8 hours to obtain polystyrene latex microspheres with an average particle size of 87.46 nm.

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Abstract

The invention relates to polystyrene latex microspheres and a preparation method thereof. The raw materials for preparing the polystyrene latex microspheres comprise water and components with the following concentrations in the water: 100-200 g / L of a styrene monomer, 400-4000 mg / L of an initiator and 1000-5000 mg / L of a surfactant. The polystyrene latex microsphere is not easy to agglutinate in the process of coupling with a specific substance, so that the coupling success rate and the coupling efficiency can be improved.

Description

technical field [0001] The invention relates to the technical field of biological detection reagents, in particular to a polystyrene latex microsphere and a preparation method thereof. Background technique [0002] In order to realize the detection and analysis of the immune response, the latex is usually coupled with specific substances that can specifically capture the analyte, such as antigens, antibodies, ligands or receptors of the analyte, lectins, and nucleic acid aptamers Wait. Therefore, when a specific reaction occurs, the immune response can be amplified macroscopically, and thus can be detected and analyzed more easily. Therefore, the coupling technology of latex and specific substances has been widely used in analytical platforms such as immunoturbidimetry, quantitative lateral flow chromatography, flow cytometry, fluorescent enzyme-linked immunosorbent adsorption, and biosensors. [0003] Polystyrene latex microspheres are a traditional type of latex, which a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F212/08C08F220/06C08F2/26C08F2/30C08F220/58C08F8/00G01N21/31G01N33/546
CPCC08F212/08C08F8/00G01N21/31G01N33/54313C08F2/26C08F2/30C08F220/06C08F220/585
Inventor 贾鸿瑞刘枫张晓倩张汉遥
Owner SICHUAN ANKERUI NEW MATERIAL TECH CO LTD
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