Medical stent for digestive system and manufacturing method thereof

Abstract

The invention provides a medical stent for a digestive system. The medical stent is obtained by 3D printing of a degradable polymer material, and at least comprises two continuous layers of three-dimensional grid structures in the radial direction, wherein the outer layer of three-dimensional grid structure is formed by printing a degradable polymer main material, the inner layer of three-dimensional grid structure is formed by composite printing of the degradable polymer main material and at least one degradable polymer auxiliary material, and the degradation of all the degradable polymer auxiliary materials is earlier than that of the degradable polymer main material; and in the inner layer of three-dimensional grid structure, the extension area of the continuous and continuous part of at least part of the degradable polymer main material in the axial direction of the whole medical stent on the radial cross section of the inner layer of three-dimensional grid structure is not less than 20% of the total area of the radial cross section of the inner layer of three-dimensional grid structure. The degradable medical stent is manufactured by means of a 3D printing process, fine adjustment of mechanical properties and control of drug release and degradation period are realized through planning of the main and auxiliary materials, and the overall performance of the more universal medical stent for the digestive system is optimized.

Description

technical field [0001] The invention relates to the technical field of manufacturing medical materials, in particular to a medical bracket for digestive system and a manufacturing method thereof. Background technique [0002] Medical stents for the digestive system mainly refer to various gastrointestinal stents. At present, gastrointestinal stent implantation has been increasingly used for the treatment of patients with gastrointestinal stenosis or gastrointestinal obstruction. In clinical practice, according to the location of different lesions Inserting the corresponding digestive tract stent can effectively rebuild the patency of the digestive tract. Because of its simple operation and small trauma, it can be applied to the treatment of esophagus, stomach, duodenum, colorectum and bile duct. [0003] The most clinically used digestive tract stents are mainly non-degradable polymer materials such as polyethylene and some metal materials such as stainless steel and nickel-...

AI Technical Summary

Problems solved by technology

[0005] At present, some technologies have proposed that in the 3D printing process of digestive tract stents, different printing materials should be selected according to the characteristics of different segments of the digestive tract. Material elasticity and hardness are planned to adapt to the characteristics of the digestive tract of this segment, and the different requirements of the structure (such as expansion coefficient). However, because this technology needs to select materials strictly according to the structure of the individual digestive tract, it is generally impossible to conduct sufficient experimental verification on individual patients clinically. , its application is very limited

[0006] At present, the material planning method of 3D printing has not broken away from the limitation of the above-mentioned "functional partition" idea, and has not been well used to optimize the overall performance of the more general digestive system medical stent, especially not used to optimize the biodegradable high Study on the mechanical properties of molecular materials for digestive system scaffolds and their mode of action in the human body

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