Externally applied traditional Chinese medicine composition, preparation and preparation method thereof capable of inhibiting skin non-enzymatic glycosylation

A non-enzymatic glycosylation, skin care composition technology, applied in the field of external Chinese medicine compositions, can solve problems such as use restrictions, and achieve the effects of skin luster and color improvement, good effect, and yellowing effect.

Active Publication Date: 2022-05-03
BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because it has certain side effects, it is subject to many restrictions in use.

Method used

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  • Externally applied traditional Chinese medicine composition, preparation and preparation method thereof capable of inhibiting skin non-enzymatic glycosylation
  • Externally applied traditional Chinese medicine composition, preparation and preparation method thereof capable of inhibiting skin non-enzymatic glycosylation
  • Externally applied traditional Chinese medicine composition, preparation and preparation method thereof capable of inhibiting skin non-enzymatic glycosylation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation of embodiment 1 Chinese medicine composition of the present invention

[0046] (1) Take the crude drug according to the following proportioning ratio, pulverize successively and pass through a 10-mesh sieve, and mix well;

[0047] 20g tangerine peel, 20g roasted licorice, 20g perilla, 20g grass cardamom, 20g grass fruit

[0048] (2) Extract with 80% ethanol by volume percentage, the g / mL mass volume ratio of crude drug and ethanol is 1:30, and ultrasonically extract for 30 minutes to obtain the extract;

[0049] (3) vacuum filter the extract obtained in step (2) through 0.45 μm filter paper to obtain the filtrate;

[0050] (4) concentrating the obtained filtrate with ethanol by rotary evaporation to 10% of the original volume to obtain a concentrate;

[0051] (5) The concentrate is freeze-dried to obtain the freeze-dried powder of the Chinese medicine extract.

Embodiment 2

[0052] The preparation of embodiment 2 Chinese medicine composition of the present invention

[0053] (1) Take the crude drug according to the following proportioning ratio, pulverize successively and pass through a 10-mesh sieve, and mix well;

[0054]20g tangerine peel, 30g roasted licorice, 10g perilla, 20g grass cardamom, 30g grass fruit

[0055] (2) Extract with 60% ethanol by volume percentage, the g / mL mass-volume ratio of crude drug and ethanol is 1:10, and ultrasonically extract for 40 minutes to obtain the extract;

[0056] (3) vacuum filter the extract obtained in step (2) through 0.45 μm filter paper to obtain the filtrate;

[0057] (4) concentrating the obtained filtrate to 8% of the original volume by rotary evaporating ethanol to obtain a concentrate;

[0058] (5) The concentrate is freeze-dried to obtain the freeze-dried powder of the Chinese medicine extract.

Embodiment 3

[0059] The preparation of embodiment 3 Chinese medicine composition of the present invention

[0060] (1) Take the crude drug according to the following proportioning ratio, pulverize successively and pass through a 10-mesh sieve, and mix well;

[0061] 20g tangerine peel, 20g roasted licorice, 30g perilla, 30g grass cardamom, 10g grass fruit

[0062] (2) Extract with 90% ethanol by volume percentage, the g / mL mass volume ratio of crude drug and ethanol is 1:20, and ultrasonically extract for 40 minutes to obtain the extract;

[0063] (3) vacuum filter the extract obtained in step (2) through 0.45 μm filter paper to obtain the filtrate;

[0064] (4) concentrating the obtained filtrate with ethanol by rotary evaporation to 10% of the original volume to obtain a concentrate;

[0065] (5) The concentrate is freeze-dried to obtain the freeze-dried powder of the Chinese medicine extract.

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Abstract

The invention discloses an external Chinese medicine composition with the effect of inhibiting skin non-enzyme glycosylation. The Chinese medicine composition is made of the following raw materials in proportions by weight: 10-30 dried tangerine peel, 10-30 dried licorice, Perilla 10-30, Cardamom 10-30, Tsaoko 10-30. The external application of the traditional Chinese medicine extract of the present invention has better inhibitory effect on the early and mid-stage products of non-enzymatic glycosylation. The inhibitory effect at the concentration of 2% is obviously better than that of the positive drug aminoguanidine. The extract of the present invention has a better inhibitory effect on the final product of fibroblast malondialdehyde MDA in the lipid peroxidation reaction at a low concentration. Experiments on volunteers showed that the facial mask prepared from the extract of the present invention significantly increased the degree of redness and decreased the degree of yellowness of the facial skin, had better anti-yellowing effect, and improved the luster of the skin to a certain extent.

Description

technical field [0001] The invention relates to an external Chinese medicine composition, in particular to an external Chinese medicine composition with the effect of inhibiting skin non-enzymatic glycosylation and a skin care preparation prepared from the skin care composition. Background technique [0002] Dark complexion is a major skin problem that plagues Chinese women. According to the data released by Mr. Shohei Tamura of Shiseido (China) Research and Development Center at the Cosmetic Personal Care Innovation Development Trend Forum of the 2019 China International Cosmetic Personal and Home Care Products Raw Materials Exhibition, "dull", "no sense of transparency", "panorama" The four keywords of "yellow" and "lack of luster" occupy the top four in Chinese women's awareness of skin problems. It can be seen that the dark and dull complexion of the face has a great influence on Chinese women. To sum up, there are three factors that lead to dark yellow skin, (1) lipid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9064A61P17/00A61P17/18A61K8/9794A61K8/9789A61Q19/00A61Q19/08
CPCA61K36/752A61K36/484A61K36/535A61K36/9062A61K36/9064A61K9/0014A61P17/00A61P17/18A61K8/9794A61K8/9789A61Q19/00A61Q19/08A61K2236/333A61K2236/51A61K2800/84A61K2300/00
Inventor 董银卯易帆孟宏李丽王诗旖
Owner BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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